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Fig. 1 | Journal of Pharmaceutical Health Care and Sciences

Fig. 1

From: A case report involving suppressed nuclear receptor transcription factors 4a1 and Stevens-Johnson syndrome induced by a single dose of pembrolizumab and successfully treated with early steroid administration, resulting in complete remission of stage III lung cancer

Fig. 1

A-F Changes in clinical valuables during the observation periods. A Plasma concentration of pembrolizumab (■), administered at a dose of 200 mg by intravenous infusion on Day 0, and dose of oral prednisolone (■), started at 60 mg/day from Day 21 and slowly tapered off until Day 77. B Changes in the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio. C Relative plasma cytokine concentrations. The black line indicates IL-10, the black dotted line indicates IL-17, and the gray line indicates IL-27. D Relative plasma cytokine concentrations. The black line indicates IFN-γ, the black dotted line indicates IL-23, the gray line indicates IL-6, and the gray dotted line indicates TGF-β. E Relative expression of mRNAs in peripheral blood mononuclear cells. The black line indicates Nr4a1 mRNA, the black dotted line indicates RORγt mRNA, the gray line indicates Lag3 mRNA, and the gray dotted line indicates Runx3 mRNA. F Relative expression of mRNAs in peripheral blood mononuclear cells. The black line indicates Nr4a2 mRNA, the black dotted line indicates Fox3 mRNA, and the gray line indicates IL-23 receptor (IL-23R) mRNA

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