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Fig. 3 | Journal of Pharmaceutical Health Care and Sciences

Fig. 3

From: A case report involving suppressed nuclear receptor transcription factors 4a1 and Stevens-Johnson syndrome induced by a single dose of pembrolizumab and successfully treated with early steroid administration, resulting in complete remission of stage III lung cancer

Fig. 3

Diagram of the assumed relationship of indices in the SJS case. Possible facilitating relationships are indicated by arrows, and inhibitory relationships are indicated by dotted arrows based on a single regression analysis. Acute inductions of IFN-γ, IL-17 and suppression of IL-10, supposed to be influenced by the suppressed Nr4a1 mRNA, assumed to contribute to the onset of SJS. Pembrolizumab and prednisolone assumed to contribute to the suppression of Nr4a1 in this case

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Journal of Pharmaceutical Health Care and Sciences

ISSN: 2055-0294

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