Table 2 Simple regression analysis of the pembrolizumab level, prednisolone dose, predictive factors for serious immune-related adverse events and immune response indices, such as selected immune response indices related to blood levels of Nr4a1 and Nr4a2 mRNA
Dependent variables | Independent variables | Unstandardized coefficient | df | R2 | F | P values |
|---|---|---|---|---|---|---|
IL-17 | Nr4a1 mRNA | -44.64 | 1, 8 | 0.68 | 14.7 | 0.006** |
Nr4a2 mRNA | 14.77 | 1, 8 | 0.22 | 2.0 | 0.204 | |
IFN-γ | Nr4a1 mRNA | -10.70 | 1, 8 | 0.51 | 7.4 | 0.030* |
Nr4a2 mRNA | -0.96 | 1, 8 | 0.01 | 0.1 | 0.778 | |
IL-10 | Nr4a1 mRNA | 2.19 | 1, 8 | 0.45 | 5.7 | 0.048* |
Nr4a2 mRNA | -0.53 | 1, 8 | 0.08 | 0.6 | 0.467 | |
Foxp3 mRNA | Nr4a1 mRNA | -0.02 | 1, 8 | 0.00 | 0.0 | 0.901 |
Nr4a2 mRNA | 0.13 | 1, 8 | 0.47 | 6.1 | 0.043* | |
Lag3 mRNA | Nr4a1 mRNA | 0.14 | 1, 8 | 0.16 | 1.3 | 0.289 |
Nr4a2 mRNA | 0.05 | 1, 8 | 0.05 | 0.4 | 0.554 | |
RORγt mRNA | Nr4a1 mRNA | -0.03 | 1, 8 | 0.01 | 0.1 | 0.824 |
Nr4a2 mRNA | 0.06 | 1, 8 | 0.08 | 0.6 | 0.474 | |
IL-23R mRNA | Nr4a1 mRNA | -0.62 | 1, 8 | 0.40 | 4.7 | 0.068 |
Nr4a2 mRNA | 0.38 | 1, 8 | 0.05 | 0.4 | 0.043* | |
Nr4a1 mRNA | Prednisolone | -0.13 | 1, 8 | 0.65 | 12.9 | 0.009** |
Pembrolizumab | -0.15 | 1, 8 | 0.77 | 19.8 | 0.004** | |
Nr4a2 mRNA | Prednisolone | 0.08 | 1, 8 | 0.08 | 0.62 | 0.457 |
Pembrolizumab | 0.00 | 1, 8 | 0.00 | 0.00 | 0.983 | |
NLR | Nr4a1 mRNA | -0.46 | 1, 8 | 0.18 | 1.578 | 0.249 |
Nr4a2 mRNA | 0.07 | 1, 8 | 0.01 | 0.089 | 0.774 | |
PLR | Nr4a1 mRNA | -3.09 | 1, 8 | 0.00 | 0.021 | 0.889 |
Nr4a2 mRNA | -6.13 | 1, 8 | 0.04 | 0.251 | 0.632 |