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  1. Bladder cancer patients receiving methotrexate, vinblastine, adriamycin and cisplatin (MVAC) chemotherapy are co-administered with dexamethasone as an anti-emetic. We examined whether or not dexamethasone affe...

    Authors: Shingo Itai, Yukio Suga, Yusuke Hara, Kouji Izumi, Yuji Maeda, Yasuhide Kitagawa, Junko Ishizaki, Tsutomu Shimada, Atsushi Mizokami and Yoshimichi Sai

    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:3

    Content type: Research article

    Published on:

  2. Medication self-management in stroke patients is important to prevent further progression of disease and incidence of side effects. The purpose of this study was to create a formula for predicting medication s...

    Authors: Hisato Fujihara, Mari Kogo, Isao Saito, Nobuyuki Kawate, Masazumi Mizuma, Hiroko Suzuki, Jun-ichiro Murayama and Tadanori Sasaki

    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:2

    Content type: Research article

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  3. Few studies have reported the dosage of cefmetazole (CMZ) for intraoperative antimicrobial prophylaxis in patients underwent surgery for colorectal cancer. We therefore examined the optimal intraoperative dosa...

    Authors: Atsushi Tomizawa, Takatoshi Nakamura, Toshiaki Komatsu, Hiroshi Inano, Rumiko Kondo, Masahiko Watanabe and Koichiro Atsuda

    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:1

    Content type: Research article

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  4. Methotrexate (MTX) is currently the anchor drug widely used worldwide in the treatment of rheumatoid arthritis (RA). However, the therapeutic response to MTX has been shown to vary widely among individuals, ge...

    Authors: Masayuki Hashiguchi, Mikiko Shimizu, Jun Hakamata, Tomomi Tsuru, Takanori Tanaka, Midori Suzaki, Kumika Miyawaki, Takeshi Chiyoda, Osamu Takeuchi, Jiro Hiratsuka, Shin Irie, Junya Maruyama and Mayumi Mochizuki

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:35

    Content type: Research article

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  5. Hyperphosphatemia is one of the common complications in patients undergoing hemodialysis. Although calcium carbonate (CaC) is often used to control serum inorganic phosphorus level in dialysis patients, co-adm...

    Authors: Masaomi Tatsuzawa, Ryuichi Ogawa, Atsushi Ohkubo, Kazuyo Shimojima, Kunimi Maeda, Hirotoshi Echizen and Akihisa Miyazaki

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:34

    Content type: Research article

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  6. There are currently no promising therapies available to treat or prevent peripheral neuropathy (PN) induced by anticancer drugs in a cumulative dose-dependent manner. In this study, we investigated the efficac...

    Authors: Junya Sato, Megumi Mori, Satoru Nihei, Masumi Kumagai, Satoshi Takeuchi, Masahiro Kashiwaba and Kenzo Kudo

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:33

    Content type: Research article

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  7. The coreceptor tropism testing should be conducted prior to commencing a regimen containing a CCR5 antagonist for treatment of HIV-1 infection. For aviremic patients on long antiretroviral therapy, proviral DN...

    Authors: Hiroshi Kotani, Koji Sudo, Naoki Hasegawa, Hiroshi Fujiwara, Tomohisa Hayakawa, Osamu Iketani, Masaya Yamaguchi, Mayumi Mochizuki, Satoshi Iwata and Shingo Kato

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:31

    Content type: Research article

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  8. Consideration of medical costs as well as effectiveness and adverse events is rapidly been becoming an important factor in the selection of chemotherapy regimens. However, practical data on the costs of chemot...

    Authors: Kosuke Takata, Ken-ichi Fujita, Yutaro Kubota, Hiroo Ishida, Wataru Ichikawa, Ken Shimada, Takashi Sekikawa, Iori Taki-Takemoto, Daisuke Kamei, Shinichi Iwai and Yasutsuna Sasaki

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:30

    Content type: Research article

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  9. Pregabalin is recommended as an adjuvant analgesic for neuropathic cancer-related pain, and may be taken at all steps of the World Health Organization analgesic ladder. However, unlike opioids, pregabalin trea...

    Authors: Ryo Yajima, Kazuaki Matsumoto, Yuya Ise, Norihito Suzuki, Yuta Yokoyama, Junko Kizu and Shiro Katayama

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:29

    Content type: Research article

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  10. The exposure of healthcare workers to anticancer drugs such as cyclophosphamide (CPA) is a serious health concern. Anticancer drug pollution may spread outside biological safety cabinets even when a closed sys...

    Authors: Junya Sato, Atushi Kogure and Kenzo Kudo

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:28

    Content type: Research article

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  11. It is well-documented that chronic kidney disease (CKD) often results in end-stage renal failure and puts patients at extremely high risk for developing cardiovascular disease. Educational hospitalization at m...

    Authors: Eiji Kose, Taesong An, Akihiko Kikkawa and Hiroyuki Hayashi

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:27

    Content type: Research article

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  12. Exposure to anticancer drugs is hazardous and may lead to chromosomal abnormalities and spontaneous abortion in healthcare workers. Guidelines recommend surface decontamination and cleaning in order to minimiz...

    Authors: Ayumi Tsukamoto, Shunji Ishiwata, Asami Kajimoto, Ryusuke Murata, Rika Kitano, Tomomi Inoue and Takeshi Kotake

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:26

    Content type: Research article

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  13. This study aimed to develop a simultaneous determination method for tramadol and its desmethylates in human plasma using isocratic liquid chromatography coupled to tandem mass spectrometry and to validate it f...

    Authors: Hironari Tanaka, Takafumi Naito, Yasuaki Mino and Junichi Kawakami

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:25

    Content type: Research article

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  14. Taxanes are known to cause onychopathy. Previous studies have reported the relationship between onychopathy and paclitaxel dosing intervals and cumulative doses. However, there are no studies of the predictive...

    Authors: Hidenobu Takahata, Kouichi Tanabe, Akiyoshi Takaki, Tsuneaki Yamanouchi, Yasuhiko Mimura, Atsumi Nitta, Hatsuna Yasuda, Tatsuhiko Kashii and Isao Adachi

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:24

    Content type: Research article

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  15. Hypomagnesemia is one of the characteristic side effects of the human anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, cetuximab and panitumumab.

    Authors: Toshiyasu Tsujii, Takafumi Ogaki, Kaori Nakae, Kiyotaka Imai, Daisuke Kise, Shoji Tada, Hiroki Ueda and Masahiro Moriyama

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:23

    Content type: Short report

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  16. Plasma tenofovir (TFV) trough concentrations may be relevant for tenofovir disoproxil fumarate (TDF)-induced renal dysfunction. The purpose of this study was to determine the association between plasma TFV tro...

    Authors: Yusuke Kunimoto, Hiroshi Ikeda, Satoshi Fujii, Manabu Kitagawa, Kieko Yamazaki, Hiromasa Nakata, Norimasa Noda, Tadao Ishida and Atsushi Miyamoto

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:22

    Content type: Research article

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  17. A new formulation of olanzapine available for terminally ill patients is needed. Rectal administration using suppositories is an alternative for patients for whom administration via the oral route is not feasi...

    Authors: Kazuaki Matsumoto, Satoru Kimura, Kenichi Takahashi, Yuta Yokoyama, Masayuki Miyazawa, Satoko Kushibiki, Morio Katamachi and Junko Kizu

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:20

    Content type: Research article

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  18. Many pharmacists are participating in team-based medical care in emergency hospitals. Therefore, there is a desperate need to improve the education system. In the present study, we provided a “pharmaceutical l...

    Authors: Yoshito Zamami, Toru Imai, Masaki Imanishi, Kenshi Takechi, Naoko Shiraishi, Toshihiro Koyama, Hidenori Sagara, Yasukazu Shiino, Toshiaki Sendo and Keisuke Ishizawa

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:21

    Content type: Research article

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  19. Sivelestat, a neutrophil elastase inhibitor, was previously approved in Japan for the treatment of acute lung injury associated with systemic inflammatory response syndrome. However, sivelestat produced incons...

    Authors: Takuma Ozawa, Kiyoshi Mihara and Nobuhiro Yasuno

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:19

    Content type: Research article

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  20. We investigated the pharmacokinetics of etoposide (ETP) to reduce the inter-individual variations of ETP concentrations in patients with acute leukemia who underwent allogeneic hematopoietic stem cell transpla...

    Authors: Yuki Tazawa, Akio Shigematsu, Kumiko Kasashi, Junichi Sugita, Tomoyuki Endo, Takeshi Kondo, Takanori Teshima, Ken Iseki, Mitsuru Sugawara and Yoh Takekuma

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:18

    Content type: Research article

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  21. Catheter ablation is a non-medication therapy for atrial fibrillation, and during the procedure, warfarin is withdrawn in the preoperative period to prevent the risk of bleeding. In case of emergency, vitamin K2 ...

    Authors: Zhi Zhou, Ikuko Yano, Sumiko Odaka, Yosuke Morita, Satoshi Shizuta, Mamoru Hayano, Takeshi Kimura, Akinori Akaike, Ken-ichi Inui and Kazuo Matsubara

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:17

    Content type: Research article

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  22. Genotype frequencies for chemotherapy-induced nausea and vomiting (CINV)-related polymorphisms have not yet been reported for Japanese subjects.

    Authors: Aya Goto, Haruka Kotani, Masayuki Miyazaki, Kiyofumi Yamada, Kazuhiro Ishikawa, Yasuhiko Shimoyama, Toshimitsu Niwa, Yoshinori Hasegawa and Yukihiro Noda

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:16

    Content type: Research article

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  23. Regorafenib and its metabolites may inhibit the activities of several CYP or UDP-glucuronosyltransferase isoforms, including that of CYP2C9. Therefore, pharmacological agents that are CYP2C9 substrates may sho...

    Authors: Hironori Kitade, Azusa Hiromasa-Yamasaki, Kengo Hokkoku, Mitsue Mori, Michio Watanabe, Masuo Nakai and Seiji Yano

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:15

    Content type: Case report

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  24. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse reactions associated with fatal disorders. Although many causes of SJS/TEN have been proposed, the time-to-onset...

    Authors: Junko Abe, Ryogo Umetsu, Kanako Mataki, Yamato Kato, Natsumi Ueda, Yoko Nakayama, Yuuki Hane, Toshinobu Matsui, Haruna Hatahira, Sayaka Sasaoka, Yumi Motooka, Hideaki Hara, Zenichiro Kato, Yasutomi Kinosada, Naoki Inagaki and Mitsuhiro Nakamura

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:14

    Content type: Research article

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  25. Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic inflammatory status, joint destruction, disability, and pain. Methotrexate (MTX) has been confirmed to reduce disease activit...

    Authors: Masayuki Hashiguchi, Tomomi Tsuru, Kumika Miyawaki, Midori Suzaki, Jun Hakamata, Mikiko Shimizu, Shin Irie and Mayumi Mochizuki

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:13

    Content type: Research article

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  26. We formulated mianserin suppositories for the treatment of delirium and evaluated their pharmacokinetics by measuring plasma drug concentrations in dogs and healthy human volunteers.

    Authors: Shuichi Nawata, Noriko Kohyama, Naoki Uchida, Satoshi Numazawa, Masayuki Ohbayashi, Yasuna Kobayashi, Masanori Iwata, Takanori Nakajima, Hiroshi Saito, Akira Izuka and Toshinori Yamamoto

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:12

    Content type: Research article

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  27. Osteoporosis is estimated to afflict over 200 million people worldwide and healthcare professionals are needed to successfully intervene. The aim of this study was to assess cognitive changes in students perta...

    Authors: Erisa Tomishige-Mukai, Akio Kawachi, Erika Kiyohara, Fuminori Esaki, Junichiro Sonoda, Tomohiro Shinya, Keiko Narumi, Keizo Sato and Toshiro Motoya

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:11

    Content type: Research article

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  28. Voriconazole concentrations display a large variability, which cannot completely be explained by known factors. We investigated the relationships of voriconazole concentration with patient-specific variables a...

    Authors: Satoshi Dote, Maki Sawai, Ayumu Nozaki, Kazumasa Naruhashi, Yuka Kobayashi and Hirokazu Nakanishi

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:10

    Content type: Research article

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  29. This study was designed to evaluate the population pharmacokinetics (popPK) of penicillin G in patients with infective endocarditis and establish a dosage regimen based on pharmacokinetic data and clinical out...

    Authors: Toshiaki Komatsu, Takayuki Inomata, Ichiro Watanabe, Masahiro Kobayashi, Hideya Kokubun, Junya Ako and Koichiro Atsuda

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:9

    Content type: Research article

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  30. The increased risk of new-onset diabetes with statin use, including high-potency statins, is well known. However, the effects of high-potency statins on HbA1c are unclear. A retrospective cohort study was cond...

    Authors: Nobuhiro Ooba, Shoutarou Tanaka, Yu Yasukawa, Nariyasu Yoshino, Hiroyuki Hayashi, Shinji Hidaka, Toshiichi Seki and Noriyasu Fukuoka

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:8

    Content type: Research article

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  31. High-dose methotrexate (HDMTX) is used in the treatment of certain malignancies, including leptomeningeal metastases, systemic non-Hodgkin lymphoma, acute lymphoblastic leukemia, and osteosarcoma. High circula...

    Authors: Tetsuya Kaneko, Takashi Fujioka, Yosuke Suzuki, Yuhki Sato and Hiroki Itoh

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:7

    Content type: Short report

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  32. Cisplatin (CDDP) is used as a key anticancer drug for solid cancers, including lung cancer. However, a large quantity of fluid replacement is required to prevent renal dysfunction. This requirement have made o...

    Authors: Junya Sato, Naoto Morikawa, Hiroo Nitanai, Hiromi Nagashima, Satoru Nihei, Kohei Yamauti and Kenzo Kudo

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:6

    Content type: Research article

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  33. Atropine sulfate is an anticholinergic agent for treatment of hypertrophic pyloric stenosis and is orally administrated as a triturate with lactose hydrate. Because of the low safety margin of atropine sulfate...

    Authors: Kei Moriyama, Yoichiro Takami, Natsuki Uozumi, Akiko Okuda, Mayumi Yamashita, Rie Yokomizo, Kenichi Shimada, Takashi Egawa, Takehito Kamei and Kazunobu Takayanagi

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:4

    Content type: Short report

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  34. Debate continues about the optimal anticoagulation level for elderly Japanese patients with non-valvular atrial fibrillation (NVAF) receiving warfarin. The Japanese Circulation Society guideline has recommende...

    Authors: Atsushi Ohgushi, Takayuki Ohtani, Natsumi Nakayama, Shigeo Asai, Yoshiyuki Ishii, Atsuo Namiki, Manabu Akazawa and Hirotoshi Echizen

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:2

    Content type: Research article

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  35. Bisphosphonates (BPs) are potent antiresorptive agents used to treat osteoporosis and the complications associated with malignant bone metastasis. The aim of this study was to evaluate the incidence of bisphos...

    Authors: Mitsuhiro Nakamura, Ryogo Umetsu, Junko Abe, Toshinobu Matsui, Natsumi Ueda, Yamato Kato, Sayaka Sasaoka, Kohei Tahara, Hirofumi Takeuchi and Yasutomi Kinosada

    Citation: Journal of Pharmaceutical Health Care and Sciences 2015 1:34

    Content type: Short report

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  36. Increasing the use of generic drugs may reduce the growing healthcare spending. Nevertheless, in Japan, the generic drug market share remains low compared to that of European countries and the United States, m...

    Authors: Masanori Suzuki, Motoyasu Kanamori, Tomoaki Hashimoto, Yuji Hashimoto, Ryohkan Funakoshi and Tadanori Sasaki

    Citation: Journal of Pharmaceutical Health Care and Sciences 2015 2:1

    Content type: Research article

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  37. The implementation of a protocol has been associated with improvements in the processes of care in clinical settings. Although stress ulcer prophylaxis is recommended for critically ill patients at high risk, ...

    Authors: Mai Ikemura, Shinji Nakasako, Ryutaro Seo, Takahiro Atsumi, Koichi Ariyoshi and Tohru Hashida

    Citation: Journal of Pharmaceutical Health Care and Sciences 2015 1:33

    Content type: Research article

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  38. Pregabalin, a gabapentinoid, is an adjuvant analgesic for treatment of neuropathic pain, but it has serious adverse effects such as somnolence and dizziness, particularly in elderly patients. Although decrease...

    Authors: Akihiro Ohishi, Yugo Chisaki, Daiki Hira, Kazuki Nagasawa and Tomohiro Terada

    Citation: Journal of Pharmaceutical Health Care and Sciences 2015 1:30

    Content type: Research article

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  39. Concomitant use of clarithromycin (CAM) and rifampicin (RFP) for the treatment of pulmonary Mycobacterium avium complex (MAC) disease affects the systemic concentrations of both drugs due to CYP3A4–related intera...

    Authors: Hitoshi Shimomura, Sena Andachi, Takahiro Aono, Akira Kigure, Yosuke Yamamoto, Atsushi Miyajima, Takashi Hirota, Keiko Imanaka, Toru Majima, Hidenori Masuyama, Koichiro Tatsumi and Takao Aoyama

    Citation: Journal of Pharmaceutical Health Care and Sciences 2015 1:32

    Content type: Research Article

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  40. Continuous hemodiafiltration (CHDF) is used as renal replacement therapy for critically ill patients with renal failure, and to treat hypercytokinemia. Since CHDF also clears therapeutic agents, drug pharmacok...

    Authors: Gaku Akashita, Yuto Hosaka, Toru Noda, Kazuya Isoda, Tsutomu Shimada, Kazuki Sawamoto, Ken-ichi Miyamoto, Takumi Taniguchi and Yoshimichi Sai

    Citation: Journal of Pharmaceutical Health Care and Sciences 2015 1:31

    Content type: Research Article

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  41. Screening for hepatitis B virus (HBV) infection is recommended worldwide for patients receiving systemic chemotherapy in accordance with clinical guidelines, but compliance varies by country and facility. Aler...

    Authors: Akimasa Sanagawa, Junko Kuroda, Arufumi Shiota, Noriko Kito, Masashi Takemoto, Yoshihiro Kawade, Tetsuo Esaki and Kazunori Kimura

    Citation: Journal of Pharmaceutical Health Care and Sciences 2015 1:29

    Content type: Research Article

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  42. Febuxostat is a novel xanthine oxidase inhibitor. However, few studies have examined the long-term efficacy and tolerability of febuxostat after switching from allopurinol in hemodialysis (HD) patients. Theref...

    Authors: Satoru Mitsuboshi, Hitoshi Yamada, Kazuhiko Nagai and Hideo Okajima

    Citation: Journal of Pharmaceutical Health Care and Sciences 2015 1:28

    Content type: Short report

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  43. The purpose of this study was to highlight concerns with the current pharmacy practice program and suggest aspects for improvement. A further aim of the study was to enhance the educational effects of the prog...

    Authors: Miho Utsumi, Sachi Hirano, Yuki Fujii and Hiroshi Yamamoto

    Citation: Journal of Pharmaceutical Health Care and Sciences 2015 1:27

    Content type: Research article

    Published on:

  44. Maintainance of a stable basal insulin level is important for glycemic control in treatment of diabetes mellitus. Recently introduced insulin degludec has the longest duration of action among basal insulin for...

    Authors: Morihiro Okada, Masae Okada, Jun Nishigami, Naoto Yamaaki, Kenji Furukawa, Kiminori Ohyama, Tsutomu Shimada and Yoshimichi Sai

    Citation: Journal of Pharmaceutical Health Care and Sciences 2015 1:26

    Content type: Research article

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  45. This study aimed to evaluate the population pharmacokinetics of digoxin in Japanese patients and establish a dosage regimen based on the pharmacokinetic data.

    Authors: Toshiaki Komatsu, Mami Morita, Futaba Miyaji, Takayuki Inomata, Junya Ako and Koichiro Atsuda

    Citation: Journal of Pharmaceutical Health Care and Sciences 2015 1:25

    Content type: Research article

    Published on:

  46. Fluoroquinolones are often used for the treatment of refractory Mycobacterium avium complex (MAC) disease when the clinical efficacy of the recommended regimen, which includes clarithromycin (CAM), rifampicin (RF...

    Authors: Hitoshi Shimomura, Airi Ono, Keiko Imanaka, Toru Majima, Hidenori Masuyama, Tsugumichi Sato and Takao Aoyama

    Citation: Journal of Pharmaceutical Health Care and Sciences 2015 1:24

    Content type: Research article

    Published on:

  47. Drug literature evaluation has been taught at pharmacy schools in the United States, allowing pharmacy students to learn how to read clinical literature critically. In advanced pharmacy practice experiences, p...

    Authors: Naoto Nakagawa, Yuriko Murai, Makiko Yoshida, Hiroyuki Suzuki and Nariyasu Mano

    Citation: Journal of Pharmaceutical Health Care and Sciences 2015 1:23

    Content type: Research article

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