Articles

Reduction in gastrointestinal bleeding by development and implementation of a protocol for stress ulcer prophylaxis: a before-after study

The implementation of a protocol has been associated with improvements in the processes of care in clinical settings. Although stress ulcer prophylaxis is recommended for critically ill patients at high risk, ...

Authors: Mai Ikemura, Shinji Nakasako, Ryutaro Seo, Takahiro Atsumi, Koichi Ariyoshi and Tohru Hashida

Opioid analgesics increase incidence of somnolence and dizziness as adverse effects of pregabalin: a retrospective study

Pregabalin, a gabapentinoid, is an adjuvant analgesic for treatment of neuropathic pain, but it has serious adverse effects such as somnolence and dizziness, particularly in elderly patients. Although decrease...

Authors: Akihiro Ohishi, Yugo Chisaki, Daiki Hira, Kazuki Nagasawa and Tomohiro Terada

Serum concentrations of clarithromycin and rifampicin in pulmonary Mycobacterium avium complex disease: long-term changes due to drug interactions and their association with clinical outcomes

Concomitant use of clarithromycin (CAM) and rifampicin (RFP) for the treatment of pulmonary Mycobacterium avium complex (MAC) disease affects the systemic concentrations of both drugs due to CYP3A4–related intera...

Authors: Hitoshi Shimomura, Sena Andachi, Takahiro Aono, Akira Kigure, Yosuke Yamamoto, Atsushi Miyajima, Takashi Hirota, Keiko Imanaka, Toru Majima, Hidenori Masuyama, Koichiro Tatsumi and Takao Aoyama

PK/PD analysis of biapenem in patients undergoing continuous hemodiafiltration

Continuous hemodiafiltration (CHDF) is used as renal replacement therapy for critically ill patients with renal failure, and to treat hypercytokinemia. Since CHDF also clears therapeutic agents, drug pharmacok...

Authors: Gaku Akashita, Yuto Hosaka, Toru Noda, Kazuya Isoda, Tsutomu Shimada, Kazuki Sawamoto, Ken-ichi Miyamoto, Takumi Taniguchi and Yoshimichi Sai

Outcomes of the implementation of the computer-assisted HBView system for the prevention of hepatitis B virus reactivation in chemotherapy patients: a retrospective analysis

Screening for hepatitis B virus (HBV) infection is recommended worldwide for patients receiving systemic chemotherapy in accordance with clinical guidelines, but compliance varies by country and facility. Aler...

Authors: Akimasa Sanagawa, Junko Kuroda, Arufumi Shiota, Noriko Kito, Masashi Takemoto, Yoshihiro Kawade, Tetsuo Esaki and Kazunori Kimura

Switching from allopurinol to febuxostat: efficacy and tolerability in hemodialysis patients

Febuxostat is a novel xanthine oxidase inhibitor. However, few studies have examined the long-term efficacy and tolerability of febuxostat after switching from allopurinol in hemodialysis (HD) patients. Theref...

Authors: Satoru Mitsuboshi, Hitoshi Yamada, Kazuhiko Nagai and Hideo Okajima

Evaluation of the pharmacy practice program in the 6-year pharmaceutical education curriculum in Japan: community pharmacy practice program

The purpose of this study was to highlight concerns with the current pharmacy practice program and suggest aspects for improvement. A further aim of the study was to enhance the educational effects of the prog...

Authors: Miho Utsumi, Sachi Hirano, Yuki Fujii and Hiroshi Yamamoto

Effect of switching basal insulin regimen to degludec on quality of life in Japanese patients with type 1 and type 2 diabetes mellitus

Maintainance of a stable basal insulin level is important for glycemic control in treatment of diabetes mellitus. Recently introduced insulin degludec has the longest duration of action among basal insulin for...

Authors: Morihiro Okada, Masae Okada, Jun Nishigami, Naoto Yamaaki, Kenji Furukawa, Kiminori Ohyama, Tsutomu Shimada and Yoshimichi Sai

Population pharmacokinetics and optimization of the dosing regimen of digoxin in adult patients

This study aimed to evaluate the population pharmacokinetics of digoxin in Japanese patients and establish a dosage regimen based on the pharmacokinetic data.

Authors: Toshiaki Komatsu, Mami Morita, Futaba Miyaji, Takayuki Inomata, Junya Ako and Koichiro Atsuda

Retrospective investigation of combination therapy with clarithromycin and levofloxacin for pulmonary Mycobacterium avium complex disease

Fluoroquinolones are often used for the treatment of refractory Mycobacterium avium complex (MAC) disease when the clinical efficacy of the recommended regimen, which includes clarithromycin (CAM), rifampicin (RF...

Authors: Hitoshi Shimomura, Airi Ono, Keiko Imanaka, Toru Majima, Hidenori Masuyama, Tsugumichi Sato and Takao Aoyama

Effects of an evidence-based medicine workshop on Japanese pharmacy students’ awareness regarding the importance of reading current clinical literature

Drug literature evaluation has been taught at pharmacy schools in the United States, allowing pharmacy students to learn how to read clinical literature critically. In advanced pharmacy practice experiences, p...

Authors: Naoto Nakagawa, Yuriko Murai, Makiko Yoshida, Hiroyuki Suzuki and Nariyasu Mano

A retrospective study to identify risk factors for somnolence and dizziness in patients treated with pregabalin

Pregabalin is a therapeutic drug for neuropathic pain that is associated with somnolence and dizziness. These adverse events are often experienced shortly after initiating pregabalin, and may lead to treatment...

Authors: Hiroshi Kato, Masayuki Miyazaki, Mio Takeuchi, Hiroaki Tsukuura, Mihoko Sugishita, Yukihiro Noda and Kiyofumi Yamada

Active topical therapy by “Furuta method” for effective pressure ulcer treatment: a retrospective study

We newly proposed that “Furuta method,” a pharmacist intervention guidelines, is a topical ointment therapy that considers the physical properties and moist environment of wounds for pressure ulcer (PU) treatm...

Authors: Katsunori Furuta, Fumihiro Mizokami, Hitoshi Sasaki and Masato Yasuhara

Prevention of the exposure by cyclophosphamide oral tablet

Unintended exposure to antitumor agents from an oral medicine may place healthcare workers and patients taking medicine at risk. In this study, the exposure to blister pack by CP (cyclophosphamide) and appropr...

Authors: Takae Hanada, Yoichiro Takami, Kei Moriyama, Masafumi Oro, Takehiro Ogawa, Hiroko Moriyasu, Yuka Inoue, Asako Kanemitsu, Eiko Kawamoto, Ayaka Nagase, Anna Hamahara, Atsuko Yamamoto, Kenichi Shimada, Masashi Takahashi and Takashi Egawa

Differences in recognition of similar medication names between pharmacists and nurses: a retrospective study

Differences in error rates between pharmacists and nurses in terms of drug confirmation have not been studied. The purpose of this study was to analyze differences in error rates between pharmacists and nurses...

Authors: Toshikazu Tsuji, Toshihiro Irisa, Shinji Tagawa, Takehiro Kawashiri, Hiroaki Ikesue, Chiyo Kokubu, Akiko Kanaya, Nobuaki Egashira and Satohiro Masuda

Evaluation of pharmacy practice program in the 6-year pharmaceutical education curriculum in Japan: hospital pharmacy practice program

The objective of this study was to clarify the state of national pharmacy practice program in the 6-year course of pharmaceutical education from the students’ point of view. We will suggest the points for impr...

Authors: Miho Utsumi, Sachi Hirano, Yuki Fujii and Hiroshi Yamamoto

The influence of dietary peptide inhibitors of angiotensin-converting enzyme on the hypotensive effects of enalapril

Enalapril is an antihypertensive medicine that inhibits angiotensin I-converting enzyme (ACE). The present study investigated interactions between enalapril and a fermented milk product (FMP) containing the AC...

Authors: Machiko Watanabe, Junichi Kurihara, Shigeto Suzuki, Kazuki Nagashima, Hiroyuki Hosono and Fumio Itagaki

Pharmacoepidemiology in Japan: medical databases and research achievements

Pharmacoepidemiology involves development of new models to predict safety in the development stages of pharmaceutical products, development of various guidelines and policy related to clinical trials, pharmaco...

Authors: Shiro Tanaka, Kahori Seto and Koji Kawakami

Hyperglycemic adverse events following antipsychotic drug administration in spontaneous adverse event reports

Antipsychotics are potent dopamine antagonists used to treat schizophrenia and bipolar disorder. The aim of this study was to evaluate the relationship between antipsychotic drugs and adverse hyperglycemic eve...

Authors: Yamato Kato, Ryogo Umetsu, Junko Abe, Natsumi Ueda, Yoko Nakayama, Yasutomi Kinosada and Mitsuhiro Nakamura

Meta-analysis of the efficacy and safety of Ginkgo biloba extract for the treatment of dementia

The benefit of Ginkgo biloba for the treatment of dementia remains controversial. The aim of this study was to evaluate the efficacy and safety of Ginkgo biloba in patients with dementia in whom administration...

Authors: Masayuki Hashiguchi, Yuriko Ohta, Mikiko Shimizu, Junya Maruyama and Mayumi Mochizuki

Onset of analgesia with ibuprofen sodium in tension-type headache: a randomized trial

Ibuprofen is known to be efficacious in the treatment of tension-type headache, the most common form of primary headache. A novel tablet formulation of ibuprofen sodium is more rapidly absorbed than standard i...

Authors: Elias Packman, Rina Leyva and David Kellstein

Adherence to changing from brand-name to generic atorvastatin in newly treated patients: a retrospective cohort study using health insurance claims

Effect of statin therapy has been reported to be associated with patient’s adherence. Atorvastatin was available in Japan as a brand-name product beginning in 2000. The first atorvastatin generics were introdu...

Authors: Yasunari Mano, Shota Fukushima, Hisayuki Kuroda, Hiroyuki Ohshima, Yoshinori Kato, Kaori Ohuchi, Kayoko Maezawa, Yasuyuki Momose, Shunya Ikeda and Mariko Asahi

Relationship between incident types and impact on patients in drug name errors: a correlational study

There are many reports regarding various medical institutions’ attempts at incident prevention, but the relationship between incident types and impact on patients in drug name errors has not been studied. Ther...

Authors: Toshikazu Tsuji, Toshihiro Irisa, Shunichi Ohata, Chiyo Kokubu, Akiko Kanaya, Masanori Sueyasu, Nobuaki Egashira and Satohiro Masuda

Supersaturated state of diazepam injection following dilution with infusion fluid

Significant precipitation produced by the dilution of diazepam (DZP) injection with an infusion fluid is a great concern for the clinical practice. In this study, the precipitation behavior under different con...

Authors: Yoshinori Onuki, Naoki Hasegawa, Chihiro Kida, Mayumi Ikegami-Kawai, Masayoshi Tsubuki, Shunsuke Shirozu, Yasuko Obata and Kozo Takayama

Pharmacoeconomic effect of compliance with pharmacist’s intervention based on cancer chemotherapy regimens: a cohort study

It is important for pharmacists to manage cancer chemotherapy regimens in order to achieve safe treatment. We examined whether there was a useful pharmacoeconomic benefit of compliance the exclusion criteria o...

Authors: Makoto Hayashi, Akimasa Yamatani, Hiromu Funaki and Kenichi Miyamoto

Correlation of plasma crizotinib trough concentration with adverse events in patients with anaplastic lymphoma kinase positive non-small-cell lung cancer

Crizotinib, an ATP-competitive receptor tyrosine kinase inhibitor of both anaplastic lymphoma kinase (ALK) and the hepatocyte growth factor receptor, commonly causes several adverse events (AEs). The clinical ...

Authors: Yasuko Kurata, Narumi Miyauchi, Manabu Suno, Takahiro Ito, Toshiaki Sendo and Katsuyuki Kiura

Effectiveness of medical supportive team for outpatients treated with sorafenib: a retrospective study

It is well known that molecular-targeted drugs, of which sorafenib (Nexavar®) is one, differ from previous anticancer drugs and cause various unusual adverse drug reactions. Treatment with sorafenib causes adv...

Authors: Makoto Kajizono, Megumu Aoyagi, Yoshihisa Kitamura and Toshiaki Sendo

Prescription rate of medications potentially contributing to lower urinary tract symptoms and detection of adverse reactions by prescription sequence symmetry analysis

The lower urinary tract symptoms (LUTS) increases with age and can have a significant effect on the quality of life of the patients. Elderly patients, who are often characterized by a decline in physiological ...

Authors: Masako Hashimoto, Kanako Hashimoto, Fumihiko Ando, Yoshiaki Kimura, Keisuke Nagase and Kunizo Arai

Photostability studies on (±)-tramadol in a liquid formulation

Tramadol ((±)-TRA) is recommended for the treatment of mild to moderate cancer pain by the World Health Organization. An oral liquid formulation of (±)-TRA is preferable for patients with a compromised swallow...

Authors: Manabu Suno, Hidenori Ichihara, Takahiro Ishino, Kento Yamamoto and Yuta Yoshizaki

Clinical risk factors associated with postoperative delirium and evaluation of delirium management and assessment team in lung and esophageal cancer patients

Delirium is an acute change in cognition and concentration that complicates the postoperative course. Patients who suffer delirium after surgery have an increased risk of persistent cognitive impairment, funct...

Authors: Kiminaka Murakawa, Yoshihisa Kitamura, Saori Watanabe, Shiho Hongo, Kazuaki Shinomiya and Toshiaki Sendo

Expected value of the additional state in evaluating the method of quantification and uncertainty of additional states in an analytical model of grade I hypertension

In the construction of pharmacoeoconomic models, simplicity is desirable for transparency (people can see how the model is built), ease of analysis, validation (how well the model reproduces reality), and desc...

Authors: Takeshi Uchikura, Makoto Kobayashi, Masayuki Hashiguchi and Mayumi Mochizuki

Pharmacist-managed clinics for patient education and counseling in Japan: current status and future perspectives

To improve the adherence to and knowledge about pharmacotherapy in outpatients and to maximize the efficacy and minimize the adverse drug events, the first pharmacist-managed clinic (PMC) in Japan was establis...

Authors: Kiyofumi Yamada and Toshitaka Nabeshima

Journal of pharmaceutical health care and sciences

Authors: Toshiya Katsura