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Table 4 Reporting ratio and ROR for antipsychotic polypharmacy

From: Hyperglycemic adverse events following antipsychotic drug administration in spontaneous adverse event reports

 

Drugs *

Total

Cases **

Reporting ratio (%)

ROR (95%CI)

Atypical

     
 

Aripiprazole

    
 

mono

11457

1645

14.4

1.4(1.3-1.5)

 

two

3499

927

26.5

3.0(2.8-3.3)

 

three

1099

606

55.1

10.3(9.1-11.6)

 

Clozapine

    
 

mono

13466

1515

11.3

1.1(1.0-1.1)

 

two

3486

584

16.8

1.7(1.5-1.8)

 

three

750

164

21.9

2.3(2.0-2.8)

 

Olanzapine

    
 

mono

13935

4226

30.3

3.7(3.6-3.8)

 

two

4862

1908

39.2

5.4(5.1-5.8)

 

three

1904

1121

58.9

12.0(11.0-13.2)

 

Quetiapine

    
 

mono

32942

7114

21.6

2.3(2.3-2.4)

 

two

6413

2556

39.9

5.6(5.3-5.9)

 

three

2175

1441

66.3

16.5(15.1-18.0)

 

Risperidone

    
 

mono

13820

2154

15.6

1.5(1.5-1.6)

 

two

4860

1476

30.4

3.7(3.4-3.9)

 

three

1917

1128

58.8

12.0(10.9-13.1)

Typical

     
 

Chlorpromazine

    
 

mono

1117

175

15.7

1.6(1.3-1.8)

 

two

724

179

24.7

2.7(2.3-3.2)

 

three

355

142

40.0

5.6(4.5-6.9)

 

Haloperidol

    
 

mono

5604

1420

25.3

2.8(2.7-3.0)

 

two

3102

704

22.7

2.5(2.3-2.7)

 

three

1079

448

41.5

5.9(5.3-6.7)

 

Prochlorperazine

    
 

mono

8514

1634

19.2

2.0(1.9-2.1)

 

two

487

111

22.8

2.5(2.0-3.0)

 

three

62

26

41.9

6.0(3.6-10.0)

  1. *Monotherapy and polypharmacy of each antipsychotic.
  2. **With adverse events of interest.