Articles

The efficacy of sodium azulene sulfonate L-glutamine for managing chemotherapy-induced oral mucositis in cancer patients: a prospective comparative study

The efficacy of sodium azulene sulfonate L-glutamine (GA) in treating oral mucositis caused by the administration of anticancer agents has not been previously elucidated. Therefore, this prospective comparativ...

Authors: Satoru Nihei, Junya Sato, Hideaki Komatsu, Kazushige Ishida, Toshimoto Kimura, Takashi Tomita and Kenzo Kudo

Risk factors for oxaliplatin-induced vascular pain in patients with colorectal cancer and comparison of the efficacy of preventive methods

Vascular pain is a common adverse drug reaction in colorectal cancer patients receiving peripheral venous administration of oxaliplatin. The aim of this work was to identify risk factors for vascular pain, and...

Authors: Yukio Suga, Nana Ikeda, Manami Maeda, Angelina Yukiko Staub, Tsutomu Shimada, Miwa Yonezawa, Hironori Kitade, Hideyuki Katsura, Morihiro Okada, Junko Ishizaki, Yoshimichi Sai and Ryo Matsushita

Pharmaceutical stability of colloidal saccharated iron oxide injection in normal saline

Colloidal saccharated iron oxide injection is used for the treatment of iron deficiency anemia in patients with a poor oral intake. Because of the poor stability of the colloid particle, there have been concer...

Authors: Daiki Hira, Asami Suzuki, Yusuke Kono, Kosuke Shimokawa, Serika Matsuoka, Ken-yuh Hasumoto, Hiroyuki Kawahara, Masahide Onoue, Takuya Fujita, Tomonobu Okano and Mikio Kakumoto

Evaluation of pharmaceutical intervention in direct-acting antiviral agents for hepatitis C virus infected patients in an ambulatory setting: a retrospective analysis

Direct-acting antivirals (DAAs) are known to improve tolerability and have higher efficacy and shorter treatment durations compared with conventional interferon (IFN)-based treatments for hepatitis C virus (HC...

Authors: Haruna Yamamoto, Hiroaki Ikesue, Mai Ikemura, Rieko Miura, Kazumi Fujita, Hobyung Chung, Yoshiki Suginoshita, Tetsuro Inokuma and Tohru Hashida

Effectiveness of scheduled postoperative intravenous acetaminophen for colon cancer surgery pain

Clinical cases are often observed when patients are in need of repeated use of analgesic infusion to manage pain after colon cancer surgery. This paper investigates analgesic frequency as well as safety of pos...

Authors: Eiji Horita, Yuji Takahashi, Kojiro Takashima, Kenichiro Saito, Yoshihiro Takashima and Yoshinori Munemoto

Possible associations of personality traits representing harm avoidance and self-directedness with medication adherence in Japanese patients with type 2 diabetes

Insufficient medication adherence in diabetes patients, of which numbers continue to increase globally, remains a critical issue. Medication adherence is multifactorial and determined by interactions among fac...

Authors: Yoshiko Tominaga, Tohru Aomori, Tomohisa Hayakawa, Nobuhiko Kijima, Donald E. Morisky, Kunihiko Takahashi and Mayumi Mochizuki

Signals of gastroesophageal reflux disease caused by incretin-based drugs: a disproportionality analysis using the Japanese adverse drug event report database

Incretin-based drugs are important in the treatment of type 2 diabetes. However, among the incretin-based drugs, glucagon-like peptide-1 receptor agonists (GLP-1-RAs) have been reported to cause gastroesophage...

Authors: Yoshihiro Noguchi, Hayato Katsuno, Anri Ueno, Manami Otsubo, Aki Yoshida, Yuta Kanematsu, Ikuto Sugita, Hiroki Esaki, Tomoya Tachi, Teruo Tsuchiya and Hitomi Teramachi

Changes in the quality of medicines during storage under LED lighting and consideration of countermeasures

In recent years, the popularity of LED lighting has rapidly increased, owing to its many advantages, including economic benefits. We examined the change in the quality of drugs during storage under LED and flu...

Authors: Shuuji Yamashita, Kazuhiro Iguchi, Yoshihiro Noguchi, Chihiro Sakai, Satoshi Yokoyama, Yoko Ino, Hideki Hayashi, Hitomi Teramachi, Magoichi Sako and Tadashi Sugiyama

Causal relationship between acute pancreatitis and methylprednisolone pulse therapy for fulminant autoimmune hepatitis: a case report and review of literature

A causal relationship between acute pancreatitis and administration of glucocorticoids remains a matter of debate, since most of the reported cases were diagnosed with systemic vascular diseases (including sys...

Authors: Daisuke Nango, Hiroki Nakashima, Yukifumi Hirose, Masaaki Shiina and Hirotoshi Echizen

Interaction between warfarin and short-term intravenous amiodarone in intensive care unit patients after cardiac surgery

Amiodarone and warfarin are sometimes administered immediately after cardiac surgery. Although the interaction between long-term oral amiodarone and warfarin has been reported, the interaction between warfarin...

Authors: Tomoki Takase, Hiroaki Ikesue, Makiko Tohi, Hiroshi Ueta, Hiroyuki Mima, Tadaaki Koyama and Tohru Hashida

Food intake attenuates the drug interaction between new quinolones and aluminum

Intestinal absorption of new quinolones is decreased by oral administration of polyvalent metal cations. Some clinical studies have demonstrated this drug - drug interaction is more prominent under fasted cond...

Authors: Ayuko Imaoka, Kosuke Abiru, Takeshi Akiyoshi and Hisakazu Ohtani

Analyses of non-benzodiazepine-induced adverse events and prognosis in elderly patients based on the Japanese adverse drug event report database

The contents of the guidelines for the use of non-benzodiazepines (Z-drugs) differ slightly between THE JAPANESE SOCIETY OF SLEEP RESEARCH and THE JAPAN GERIATRIC SOCIETY, and the recommended directions are co...

Authors: Yoshihiro Noguchi, Anri Ueno, Hayato Katsuno, Manami Otsubo, Aki Yoshida, Yuta Kanematsu, Ikuto Sugita, Tomoya Tachi, Teruo Tsuchiya and Hitomi Teramachi

Impact of pharmacist counseling on reducing instances of adverse events that can affect the quality of life of chemotherapy outpatients with breast Cancer

In recent years, cancer chemotherapy is being conducted at outpatient clinics, wherein pharmacists are involved with patient guidance and management of adverse events as experts in medication therapy. Therefor...

Authors: Kazuhide Tanaka, Akiyo Hori, Tomoya Tachi, Tomohiro Osawa, Katsuhiro Nagaya, Teppei Makino, Seiji Inoue, Masahiro Yasuda, Takashi Mizui, Takumi Nakada, Chitoshi Goto and Hitomi Teramachi

Influence of technique used to attach the infusion set to peristaltic finger smart-pumps on dispensing time: an experimental study

Infusion sets designed for peristaltic finger smart pumps (PFSPs) are necessary for the pumps’ accurate handling. We previously found that medication dispensing is occasionally incomplete following the calcula...

Authors: Masayuki Umemura, Kanae Maegawa, Daichi Arai, Katsuro Shigeno and Yoshifumi Wakiya

Comparison of PETINIA and LC-MS/MS for determining plasma mycophenolic acid concentrations in Japanese lung transplant recipients

Mycophenolic acid (MPA) treatment requires therapeutic drug monitoring to improve the outcome after organ transplantation. The aim of this study was to compare two methods, a particle enhanced turbidimetric in...

Authors: Masafumi Kikuchi, Masaki Tanaka, Shinya Takasaki, Akiko Takahashi, Miki Akiba, Yasushi Matsuda, Masafumi Noda, Kanehiko Hisamichi, Hiroaki Yamaguchi, Yoshinori Okada and Nariyasu Mano

Developmental changes of fluconazole clearance in neonates and infants in relation to ontogeny of glomerular filtration rate: literature review and data analysis

Fluconazole is frequently prescribed for the treatment of systemic fungal infection in neonates and infants. At present, prediction of fluconazole doses according to developmental changes in fluconazole cleara...

Authors: Kazutoshi Murakoso, Ryoichi Minagawa and Hirotoshi Echizen

The adoption of generic drugs by a hospital: effects on drug dispensation among community pharmacies

The objective of the current study is to elucidate the effect that the adoption of generic drugs by a large hospital has on the dispensation of generic drugs by community pharmacies. We evaluated the percentag...

Authors: Tomoya Tachi, Kosuke Saito, Hiroki Esaki, Ikuto Sugita, Aki Yoshida, Yuta Kanematsu, Yoshihiro Noguchi, Michi Umeda, Masahiro Yasuda, Takashi Mizui, Teruo Tsuchiya, Chitoshi Goto and Hitomi Teramachi

New low-dose liquid pilocarpine formulation for treating dry mouth in Sjögren’s syndrome: clinical efficacy, symptom relief, and improvement in quality of life

Patients with Sjögren’s syndrome (SS) typically present clinically with xerostomia (dry mouth) because of progressive damage to the exocrine glands. We developed a new, low-dose pilocarpine/sodium alginate (LP...

Authors: Machiko Watanabe, Chisato Yamada, Yoshinori Komagata, Hirotoshi Kikuchi, Hiroyuki Hosono and Fumio Itagaki

Changes in tear volume and ocular symptoms of patients receiving oral anticancer drug S-1

Most eye disorders are not fatal but may deteriorate the quality of life of a patient. The eye disorder that is most frequently reported in the cancer chemotherapy is associated with the combination of tegafur...

Authors: Reiko Kuriki, Tsuyoshi Hata, Kinuyo Nakayama, Yuichi Ito, Kazunari Misawa, Seiji Ito, Michiko Tatematsu and Norio Kaneda

A questionnaire survey of pharmacists regarding the clinical practice guidelines for the appropriate use of granulocyte-colony stimulating factors

Clinical practice guidelines should be user-friendly and confirming their penetration rate and compliance are critical.

Authors: Tetsuya Sasaki, Yasuhisa Kato, Atsushi Sato, Noriko Usui, Eishi Baba, Toshimi Takano, Nobuyuki Susumu, Kazunori Ohnishi, Hitomi Nishimoto and Katsuyuki Kiura

Antiemetic efficacy and safety of granisetron or palonosetron alone and in combination with a corticosteroid for ABVD therapy-induced nausea and vomiting

Antiemetic effects and safety of granisetron or palonosetron alone and in combination with a corticosteroid against chemotherapy-induced nausea and vomiting (CINV) were retrospectively evaluated in patients wi...

Authors: Mayako Uchida, Tsutomu Nakamura, Kojiro Hata, Hiroyuki Watanabe, Yasuo Mori, Koji Kato, Kenjiro Kamezaki, Katsuto Takenaka, Motoaki Shiratsuchi, Keiko Hosohata, Toshihiro Miyamoto and Koichi Akashi

Improved treatment satisfaction and medication adherence after readjusting oral medication regimens with the cooperation of health insurance pharmacy in type 2 diabetic patients in Japan

Treatment satisfaction and medication adherence can be improved if physicians carefully monitor the situations, check the level of difficulties patients experience when taking medications at specific times, an...

Authors: Naoko Ogawa, Mitsuyoshi Takahara, Toshihiko Shiraiwa, Mayumi Yamamoto, Kaoru Yamamoto, Masayuki Doi, Yoko Yoshida and Setsuko Gotou

Impact of the number of repeated inhalations and patient characteristics on the residual amount of inhaled laninamivir octanoate hydrate dry powder in pediatric patients with influenza

A dry powder inhaled formulation is used for the anti-influenza drug laninamivir octanoate hydrate (laninamivir). Although two successive inhalations (puffs) are recommended to minimize residual amounts of act...

Authors: Toshiki Murasaka, Kenji Ikemura, Tomoyuki Enokiya, Yuichi Muraki, Mayumi Ikemura, Koji Terada, Takuya Iwamoto and Masahiro Okuda

Joint symptoms associated with anastrozole and letrozole in patients with breast cancer: a retrospective comparative study

Joint symptoms are a common side effect of aromatase inhibitors. However, it is not known if the risk of these symptoms varies between the members of this drug class. The aim of this study was to compare the f...

Authors: Yoshihito Morimoto, Shuhei Sarumaru, Yuko Oshima, Chiho Tsuruta and Kazuhiro Watanabe

Association between itching and the serum zinc levels in patients with varicose veins

Varicose veins commonly occur in the lower extremities and can cause pain and discomfort in the affected area. Many patients with varicose veins suffer from itching, but its cause has not been sufficiently exp...

Authors: Yasushi Takai, Keiichi Hiramoto, Yoshiyuki Nishimura, Ryota Uchida, Keigo Nishida and Kazuya Ooi

Efficacy of switching to dolutegravir plus rilpivirine, the small-tablet regimen, in patients with dysphagia: two case reports

The advent of well-tolerated and effective anti-retroviral drugs against human immunodeficiency virus-1 (HIV-1) infection has been a major step forward that has achieved long-term survival in recent years. The...

Authors: Takefumi Suzuki, Nobuko Hara, Morichika Osa, Kazuhisa Misawa, Kazuo Imai, Yuji Fujikura, Takuya Maeda, Wataru Sonehara and Akihiko Kawana

The detection of influenza virus at the community pharmacy to improve the management of local residents with influenza or influenza-like disease

As of 2014, community pharmacies in Japan are approved by the Ministry of Health, Labour and Welfare to measure lipid panel, HbA1c, glucose, ALT, AST and γ-GTP, but not to screen for influenza virus. We provid...

Authors: Akio Kawachi, Yusuke Sakamoto, Shunya Mouri, Mitsuaki Fukumori, Riku Kawano, Takaya Murakami, Junichiro Sonoda, Keiko Narumi, Yoshihiro Shimodozono, Kenji Etoh, Susumu Chiyotanda, Takashi Furuie, Keizo Sato, Masao Fukumori and Toshiro Motoya

Objective evaluation of chemotherapy-induced peripheral neuropathy using quantitative pain measurement system (Pain Vision^®), a pilot study

In an evaluation of chemotherapy-induced peripheral neuropathy (CIPN), objectivity may be poor because the evaluation is determined by the patient’s subjective assessment. In such cases, management of neuropat...

Authors: Junya Sato, Megumi Mori, Satoru Nihei, Satoshi Takeuchi, Masahiro Kashiwaba and Kenzo Kudo

Kamishoyosan and Shakuyakukanzoto promote recovery from paclitaxel-induced neurite retraction in PC12 cells

In chemotherapy, the full round of treatment must be completed as scheduled to achieve the strongest therapeutic effect. However, peripheral neuropathy, a severe side effect of the chemotherapeutic agent pacli...

Authors: Ken Konaka, Kota Moriyama, Takumi Sakurada, Naoto Okada, Masaki Imanishi, Yoshito Zamami, Kazuyoshi Kawazoe, Shuji Fushitani and Keisuke Ishizawa

Drug-induced gingival hyperplasia: a retrospective study using spontaneous reporting system databases

Drug-induced gingival hyperplasia (DIGH) causes problems with chewing, aesthetics, and pronunciation, and leads to the deterioration of the patient’s quality of life (QOL). Thus, the aim of this study was to e...

Authors: Haruna Hatahira, Junko Abe, Yuuki Hane, Toshinobu Matsui, Sayaka Sasaoka, Yumi Motooka, Shiori Hasegawa, Akiho Fukuda, Misa Naganuma, Tomofumi Ohmori, Yasutomi Kinosada and Mitsuhiro Nakamura

Safety of human papillomavirus vaccines in healthy young women: a meta-analysis of 24 controlled studies

Human papillomavirus (HPV) vaccines have been shown to be effective for the eradication of HPV and prevention of cervical cancer. However, the number of women who receive HPV vaccinations has decreased over th...

Authors: Yukari Ogawa, Hinako Takei, Ryuichi Ogawa and Kiyoshi Mihara

Usefulness of limited sampling strategy for mycophenolic acid area under the curve considering postoperative days in living-donor renal transplant recipients with concomitant prolonged-release tacrolimus

The optimal dose of mycophenolate mofetil (MMF) in renal transplant patients has been recommended to be decided on the basis of area under the concentration-time curve (AUC_0-12) of mycophenolic acid (MPA). Althou...

Authors: Tomoyuki Enokiya, Kouhei Nishikawa, Yuichi Muraki, Takuya Iwamoto, Hideki Kanda, Yoshiki Sugimura and Masahiro Okuda

Development and evaluation of adsorption sheet (HD safe sheet-U) using active carbon for the purpose of the preventing the contamination diffusion of urinary excreted anticancer drug

Certain amount of anticancer drugs is excreted in the urine of patients receiving anticancer drugs, and urinary scattering including anticancer drugs at excretion has become a route of anticancer drug contamin...

Authors: Junya Sato, Haruka Ohkubo, Yuki Sasaki, Makoto Yokoi, Yasunori Hotta and Kenzo Kudo

Effects of resistant dextrin for weight loss in overweight adults: a systematic review with a meta-analysis of randomized controlled trials

Randomized controlled trials (RCTs) reported that resistant dextrin (RD) exerted pleiotropic effects on humans. However, limited information is available on the effects of RD for weight loss. We conducted a sy...

Authors: Junichi Mukai, Yuta Tsuge, Michiko Yamada, Katsuya Otori and Koichiro Atsuda

Effect of health foods on cytochrome P450-mediated drug metabolism

Health foods have been widely sold and consumed in Japan. There has been an increase in reports of adverse effects in association with the expanding health food market. While health food-drug interactions are ...

Authors: Takamitsu Sasaki, Yu Sato, Takeshi Kumagai, Kouichi Yoshinari and Kiyoshi Nagata

Evaluation of the permeation of antineoplastic agents through medical gloves of varying materials and thickness and with varying surface treatments

Medical gloves are an important piece of personal protective equipment that prevents exposure to antineoplastic agents. The permeability of medical gloves to antineoplastic agents is a crucial factor in the ap...

Authors: Toyohito Oriyama, Takehito Yamamoto, Yoshitsugu Yanagihara, Katsuhiko Nara, Toshihide Abe, Katsuyoshi Nakajima, Takao Aoyama and Hiroshi Suzuki

Performance evaluation of the compounding robot, APOTECAchemo, for injectable anticancer drugs in a Japanese hospital

The accuracy, safety and feasibility of, the compounding robot APOTECAchemo were evaluated in the clinical practice of Japan.

Authors: Takuya Iwamoto, Takuya Morikawa, Miki Hioki, Hirofumi Sudo, Demis Paolucci and Masahiro Okuda

Effects of communication skill training (CST) based on SPIKES for insurance-covered pharmacy pharmacists to interact with simulated cancer patients

With the development of pharmacotherapy and radiotherapy, cancer treatment is being shifted from surgical to outpatient services, consequently increasing insurance-covered pharmacies’ frequency of dealing with...

Authors: Manako Hanya, Yoshitake Kanno, Junko Akasaki, Keiko Abe, Kazuhiko Fujisaki and Hiroyuki Kamei

Erratum to: Influence of nonsteroidal anti-inflammatory drugs on aspirin’s antiplatelet effects and suggestion of the most suitable time for administration of both agents without resulting in interaction

Authors: Kenta Shibata, Yuuki Akagi, Naofumi Nozawa, Hitoshi Shimomura and Takao Aoyama

Influence of nonsteroidal anti-inflammatory drugs on aspirin’s antiplatelet effects and suggestion of the most suitable time for administration of both agents without resulting in interaction

Low-dose aspirin irreversibly inhibits platelet cyclooxygenase-1 (COX-1) and suppresses platelet aggregation. It is effective for secondary prevention of cardiovascular events. Because nonsteroidal anti-inflam...

Authors: Kenta Shibata, Yuuki Akagi, Naofumi Nozawa, Hitoshi Shimomura and Takao Aoyama

Comparison of 16S ribosomal RNA gene sequence analysis and conventional culture in the environmental survey of a hospital

Nosocomial infection is one of the most common complications within health care facilities. Certain studies have reported outbreaks resulting from contaminated hospital environments. Although the identificatio...

Authors: Akihiro Manaka, Yutaka Tokue and Masami Murakami

Drug interaction between methotrexate and salazosulfapyridine in Japanese patients with rheumatoid arthritis

Methotrexate (MTX) and salazosulfapyridine (SASP) are disease-modifying drugs that are commonly used in the treatment of rheumatoid arthritis (RA), and combination therapy with MTX and SASP is recommended for ...

Authors: Morihiro Okada, Hiroshi Fujii, Yukio Suga, Satoshi Morito, Masae Okada, Jun Nishigami, Mitsuhiro Kawano, Tsutomu Shimada and Yoshimichi Sai

Predictive factors for effectiveness and safety of enoxaparin for total knee arthroplasty in aged Japanese patients: a retrospective review

The aims of this study were to investigate predictive factors involved in effectiveness and safety of enoxaparin for prevention of postoperative venous thromboembolism in aged Japanese total knee arthroplasty ...

Authors: Akihiro Sonoda, Yuki Kondo, Yasuhiro Tsuneyoshi, Yoshitaka Iwashita, Shoji Nakao, Kazuhisa Ishida, Kentaro Oniki, Junji Saruwatari, Tetsumi Irie and Yoichi Ishitsuka

Appropriate use of a dry powder inhaler based on inhalation flow pattern

An optimal inhalation flow pattern is essential for effective use of a dry powder inhaler (DPI). We wondered whether DPI instructors inhale from a DPI with an appropriate pattern, and if not, whether self-trai...

Authors: Tetsuri Kondo, Makoto Hibino, Toshimori Tanigaki, Stanley M. Cassan, Sakurako Tajiri and Kenichro Akazawa

Impact of Pharmacists’ audit on improving the quality of prescription of dabigatran etexilate methanesulfonate: a retrospective study

Appropriate prescription of dabigatran etexilate methanesulfonate (JAN) is more complicated than assumed, because there are totally 10 items of contraindications and instructions for dosage reduction depending...

Authors: Teppei Shimizu, Yoshio Momose, Ryuichi Ogawa, Masahiro Takahashi and Hirotoshi Echizen

Co-administration of dexamethasone increases severity and accelerates onset day of neutropenia in bladder cancer patients on methotrexate, vinblastine, adriamycin and cisplatin chemotherapy: a retrospective cohort study

Bladder cancer patients receiving methotrexate, vinblastine, adriamycin and cisplatin (MVAC) chemotherapy are co-administered with dexamethasone as an anti-emetic. We examined whether or not dexamethasone affe...

Authors: Shingo Itai, Yukio Suga, Yusuke Hara, Kouji Izumi, Yuji Maeda, Yasuhide Kitagawa, Junko Ishizaki, Tsutomu Shimada, Atsushi Mizokami and Yoshimichi Sai

Development and evaluation of a formula for predicting introduction of medication self-management in stroke patients in the Kaifukuki rehabilitation ward

Medication self-management in stroke patients is important to prevent further progression of disease and incidence of side effects. The purpose of this study was to create a formula for predicting medication s...

Authors: Hisato Fujihara, Mari Kogo, Isao Saito, Nobuyuki Kawate, Masazumi Mizuma, Hiroko Suzuki, Jun-ichiro Murayama and Tadanori Sasaki

Optimal dosage of cefmetazole for intraoperative antimicrobial prophylaxis in patients undergoing surgery for colorectal cancer

Few studies have reported the dosage of cefmetazole (CMZ) for intraoperative antimicrobial prophylaxis in patients underwent surgery for colorectal cancer. We therefore examined the optimal intraoperative dosa...

Authors: Atsushi Tomizawa, Takatoshi Nakamura, Toshiaki Komatsu, Hiroshi Inano, Rumiko Kondo, Masahiko Watanabe and Koichiro Atsuda

Genetic polymorphisms of enzyme proteins and transporters related to methotrexate response and pharmacokinetics in a Japanese population

Methotrexate (MTX) is currently the anchor drug widely used worldwide in the treatment of rheumatoid arthritis (RA). However, the therapeutic response to MTX has been shown to vary widely among individuals, ge...

Authors: Masayuki Hashiguchi, Mikiko Shimizu, Jun Hakamata, Tomomi Tsuru, Takanori Tanaka, Midori Suzaki, Kumika Miyawaki, Takeshi Chiyoda, Osamu Takeuchi, Jiro Hiratsuka, Shin Irie, Junya Maruyama and Mayumi Mochizuki

Influence of proton pump inhibitors and histamine H₂ receptor antagonists on serum phosphorus level control by calcium carbonate in patients undergoing hemodialysis: a retrospective medical chart review

Hyperphosphatemia is one of the common complications in patients undergoing hemodialysis. Although calcium carbonate (CaC) is often used to control serum inorganic phosphorus level in dialysis patients, co-adm...

Authors: Masaomi Tatsuzawa, Ryuichi Ogawa, Atsushi Ohkubo, Kazuyo Shimojima, Kunimi Maeda, Hirotoshi Echizen and Akihisa Miyazaki