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  1. The anticoagulant edoxaban is used clinically at doses of 30–60 mg/day; however, we experienced a patient who had taken an overdose of edoxaban of 750 mg. We investigated the pharmacokinetics of edoxaban in th...

    Authors: Koichiro Adachi, Jumpei Tuchiya, Satoru Beppu, Kei Nishiyama, Makiko Shimizu and Hiroshi Yamazaki

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:20

    Content type: Case report

    Published on:

  2. Bevacizumab (BEV) leads to proteinuria and renal damage. It is not clear whether the administration of immunosuppressive drugs after renal transplantation affects the safety of BEV administration. We report a ...

    Authors: Ren Onodera, Satoru Nihei, Toshimoto Kimura, Takashi Tomita and Kenzo Kudo

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:19

    Content type: Case report

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  3. Ward pharmacists are required for the active implementation of therapeutic drug monitoring (TDM). This epidemiological study verified whether Japanese ward pharmacists contribute to improving the TDM implement...

    Authors: Shungo Imai, Kenji Momo, Hitoshi Kashiwagi, Takayuki Miyai, Mitsuru Sugawara and Yoh Takekuma

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:18

    Content type: Research article

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  4. Many patients with critical lower limb ischemia are not eligible for revascularization procedures. Still, given the emerging role of both platelet and coagulation activation in the formation of arterial thromb...

    Authors: Antonio Trani, Pietro Benedetto, Ferdinando Di Leo, Angela Baiano, Andrea Esposito, Danilo Menna, Arianna Allegretti, Pierluigi Antonino Cappiello and Domenico Dell’Edera

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:17

    Content type: Case report

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  5. Valganciclovir (VGC) is essential for preventing cytomegalovirus infections after transplants in adult and pediatric patients. In pediatric patients, VGC tablets have to be pulverized so that they can be deliv...

    Authors: Yasuyuki Masaoka, Yoichi Kawasaki, Ryo Kikuoka, Atsushi Ogawa, Satoru Esumi, Yudai Wada, Soichiro Ushio, Yoshihisa Kitamura and Toshiaki Sendo

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:16

    Content type: Research article

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  6. Instillation of sterile graded talc in the pleural space is performed to prevent reaccumulation of malignant pleural effusion after drainage. Talc is thought to encourage pleural adhesions as part of the repai...

    Authors: Soichiro Ishii, Hiroshi Sakurashita, Emiko Mashida, Yasuyuki Saeki and Hiroaki Matsuo

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:15

    Content type: Case report

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  7. The need for a large volume of serum sample significantly reduces the feasibility of neonatal pharmacokinetic studies in daily practice, which must often rely on scavenged or opportunistic sampling. This probl...

    Authors: Jumpei Saito, Ayano Tanzawa, Yuka Kojo, Hidehiko Maruyama, Tetsuya Isayama, Kensuke Shoji, Yushi Ito and Akimasa Yamatani

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:14

    Content type: Research article

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  8. Patients with diabetes are at higher risk of developing polypharmacy because of the high frequency of comorbidities. There have been several reports on the hypoglycemic risk of the combination of hypoglycemic ...

    Authors: Tomoyuki Saito, Hirotoshi Ohmura, Shuko Nojiri and Hiroyuki Daida

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:13

    Content type: Research article

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  9. Oral mucositis frequently occurs in cancer patients treated with chemotherapy and chemoradiotherapy (CRT). This study examined the safety and efficacy of ibuprofen gargle in healthy volunteers and patients wit...

    Authors: Takeshi Ioroi, Naomi Kiyota, Yoshinori Imamura, Masaaki Tanda, Shiori Aoki, Mamoru Okuno, Kazuhiro Yamamoto, Ryohei Sasaki, Ken-ichi Nibu, Hironobu Minami, Midori Hirai and Ikuko Yano

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:12

    Content type: Research article

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  10. Itraconazole (ITZ), a triazole antifungal agent, is metabolized to hydroxy-ITZ (OH-ITZ), keto-ITZ (KT-ITZ), and N-desalkyl ITZ (ND-ITZ) by cytochrome P450 3A4. The pharmacokinetics of ND-ITZ remain largely unknow...

    Authors: Yumi Imoto, Yasuaki Mino, Takafumi Naito, Takaaki Ono and Junichi Kawakami

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:11

    Content type: Research article

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  11. Pain treatment post orthopaedic care in the elderly is complicated and requires careful follow-up. Current guidelines state all patients prescribed opioids should have a plan for gradual reduction, with the tr...

    Authors: Gabriella Caleres, Patrik Midlöv, Åsa Bondesson and Sara Modig

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:10

    Content type: Research article

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  12. Effective treatment for human immunodeficiency virus (HIV) infection requires close cooperation among healthcare professionals. This is because maintaining continuity with treatment regimens is important in an...

    Authors: Kimihiko Urano, Miki Ishibashi, Takeshi Matsumoto, Kohshi Ohishi, Yuichi Muraki, Takuya Iwamoto, Junichi Kunimasa and Masahiro Okuda

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:9

    Content type: Research article

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  13. Autism spectrum disorder (ASD) is a neurodevelopmental disorder, mainly characterized by impairment of social communication and restricted interests. ASD is frequently accompanied by attention deficit hyperact...

    Authors: Taisuke Kitaoka, Masahito Morimoto, Toshiaki Hashimoto, Yoshimi Tsuda, Tadanori Nakatsu and Shojiro Kyotani

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:8

    Content type: Research article

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  14. Four-factor prothrombin complex concentrate (4F-PCC) must be administered as soon as possible, and in our emergency intensive care unit (EICU), pharmacists are available on weekdays for consultation on expedit...

    Authors: Shoichi Imanaka, Tatsuro Kuwabara, Hiroto Ikeda, Yasufumi Miyake, Hiromi Enomoto, Tetsuya Sakamoto and Nobuhiro Yasuno

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:7

    Content type: Research article

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  15. Interferon and ribavirin have been used as therapeutic agents for chronic hepatitis C infection or C-compensated cirrhosis in the conventional treatment. Hepatitis C virus (HCV) -specific direct-acting antivir...

    Authors: Sachiko Omotani, Toshihiko Ishizaka, Miki Inoue, Koji Nishida, Yukako Yasui, Yasutoshi Hatsuda, Junji Mukai and Michiaki Myotoku

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:6

    Content type: Case report

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  16. Repaglinide is widely prescribed to reduce postprandial hyperglycemia and elevated glycated hemoglobin (HbA1c) levels associated with type 2 diabetes, and clopidogrel is a thienopyridine antiplatelet agent and...

    Authors: Yuuki Akagi, Akiko Iketaki, Haruna Kimura, Yuki Matsudaira, Takami Yoshida, Takahiro Nishimura, Yohei Kawano, Yasunari Mano, Erina Shigematsu and Makoto Ujihara

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:5

    Content type: Research article

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  17. Few systematic reviews have examined the effects of sodium-glucose co-transporter 2 inhibitors (SGLT2is) on lipid profiles in Asian patients with type 2 diabetes mellitus. We conducted a systematic review with...

    Authors: Junichi Mukai, Ayano Yoshiyama and Rie Kubota

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:4

    Content type: Research article

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  18. Because cisplatin (CDDP) decreases upon light exposure, it is necessary to prevent such exposure during administration. However, the shielding conditions employed are not uniform. Therefore, in this study, we ...

    Authors: Tomoya Abe, Daigo Matsumoto, Toshiaki Nakayama, Yukinari Shimazaki, Atsunobu Sagara, Dan Kanehira, Takuya Azechi, Fumiaki Sato, Hiroyasu Sakai, Tetsuro Yumoto and Junzo Kamei

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:3

    Content type: Short report

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  19. Inappropriate dosing of direct oral anticoagulants (DOACs) has been associated with clinical safety and efficacy; however, little is known about clinical data associated with an inappropriate DOAC dosing in Ja...

    Authors: Motoyasu Miyazaki, Koichi Matsuo, Masanobu Uchiyama, Yoshihiko Nakamura, Yuya Sakamoto, Momoko Misaki, Kaoko Tokura, Shiro Jimi, Keisuke Okamura, Sen Adachi, Tomohiko Yamamoto, Kazuyuki Shirai, Hidenori Urata and Osamu Imakyure

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:2

    Content type: Research article

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  20. The clobetasol propionate cream formulations (CLBCr) belong to the “strongest” group, and are used widely. In addition, those formulations are often used as a mixture with moisturizer. Recently, we evaluated phar...

    Authors: Yoshihisa Yamamoto, Yoshinori Onuki, Toshiro Fukami and Tatsuo Koide

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:1

    Content type: Research article

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  21. Sipuleucel-T, an autologous active cellular immunotherapy, is indicated for the treatment of asymptomatic or minimally symptomatic castration-resistant prostate cancer. The U.S. Food and Drug Administration Ad...

    Authors: Graça M. Dores, Silvia Perez-Vilar and Manette T. Niu

    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:27

    Content type: Short report

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  22. Atropine eye drops are indicated for juvenile myopia progression, cycloplegia, amblyopia, and strabismus. According to the package insert, 10 mg/mL atropine eye drops must be diluted for pediatric patients to ...

    Authors: Jumpei Saito, Hitomi Imaizumi and Akimasa Yamatani

    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:25

    Content type: Research article

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  23. Food is known to affect drug absorption by delaying gastric emptying time, altering gastrointestinal pH, stimulating bile flow, increasing splanchnic blood flow, or physically interacting with drugs. Although ...

    Authors: Fukiko Omachi, Masaki Kaneko, Ryosuke Iijima, Machiko Watanabe and Fumio Itagaki

    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:26

    Content type: Research article

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  24. Cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) regimen includes a high dose of prednisolone (100 mg/body), which exhibits an anticancer and antiemetic effect. However, its optimal use for ...

    Authors: Yoshinori Wakasugi, Satoshi Noda, Yoshihiro Ikuno, Miya Horie, Katsuyuki Kito, Hitoshi Minamiguchi and Tomohiro Terada

    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:24

    Content type: Research article

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  25. Both polypharmacy and frailty are critical issues faced by the elderly. The decrease in gait speed is an index of frailty, and it is generally associated with falls and fractures, which are risk factors requir...

    Authors: Masataka Deguchi, Keigo Nishida, Tomoyuki Enokiya and Kazuya Ooi

    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:23

    Content type: Research article

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  26. Multiple daily subcutaneous injections (MDSIs) are mainly used for formulating an insulin therapy for diabetic patients; however, they also cause insulin-derived amyloidosis (IDA) and lead to poor glycemic con...

    Authors: Yui Ohno, Tomohiro Seki, Yu Kojima, Ryotaro Miki, Yuya Egawa, Osamu Hosoya, Keizo Kasono and Toshinobu Seki

    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:22

    Content type: Research article

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  27. Infliximab (IFX) has changed the management of many life-threatening immune-mediated diseases. The high cost of IFX and its patent expiry have led to pharmaceutical companies developing a biosimilar; however, ...

    Authors: Iku Niinomi, Keiko Hosohata, Yasuhiro Mori, Yuki Yamaguchi, Tomohito Wakabayashi, Mayako Uchida and Kazunori Iwanaga

    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:21

    Content type: Short report

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  28. There is a lack of evidence that multidrug use triggers adverse events. Therefore, the main purpose of this study was to clarify the relationship between the total number of drugs and number of high-risk presc...

    Authors: Sayaka Arai, Takahiro Ishikawa, Hisaya Kato, Masaya Koshizaka, Yoshio Maezawa, Takako Nakamura, Takaaki Suzuki, Koutaro Yokote and Itsuko Ishii

    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:20

    Content type: Short report

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  29. Chemotherapy is important for cancer treatment, but patients’ physical and mental stress may lead to unfavorable pain control, an increase in the risk of relapse, and a reduction in the quality of life (QOL). ...

    Authors: Chiaki Takagi, Saori Nakagawa, Naoto Hirata, Shin Ohta and Sadahiko Shimoeda

    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:18

    Content type: Research article

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  30. According to the Clinical Practice Guidelines for Clostridioides difficile, oral vancomycin is to be used in vancomycin tapered and pulsed regimen (VCM-TP) for recurrent Clostridium difficile infection (CDI). How...

    Authors: Takumi Umemura, Aiko Ota, Yoshikazu Mutoh, Chihiro Norizuki, Takahito Mizuno, Koji Kozaki, Yoshiaki Ikeda and Toshihiko Ichihara

    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:19

    Content type: Short report

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  31. Dabigatran is a direct thrombin inhibitor and an anticoagulant that is prescribed to prevent ischemic stroke and systemic embolism in non-valvular atrial fibrillation. Dabigatran (150 mg twice daily) is non-in...

    Authors: Yuuki Akagi, Tatsuo Chiba, Shusuke Uekusa, Hiroyoshi Kato, Shigeo Yamamura, Yukiko Aoki, Mizuho Enoki, Yuka Ogawara, Takanori Kasahara, Yuki Kimura, Tadahiro Shimizu, Aiko Takeishi, Yuko Nakajima, Hideki Kobayashi and Kaoru Sugi

    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:17

    Content type: Research article

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  32. Oral mucositis is a frequent and severe adverse event in patients undergoing chemoradiotherapy for head and neck cancers, especially grade 3 or 4 mucositis. Occurrence may result in drop-out from treatment, th...

    Authors: Shinsuke Akagi, Takashi Fujiwara, Mai Nishida, Akiko Okuda, Yuka Nagao, Toshikatsu Okuda, Hidenori Tokuda and Kazunobu Takayanagi

    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:16

    Content type: Research article

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  33. Despite the high mortality of patients with sepsis and carbapenem-resistant bacteria infection, appropriate antimicrobial therapies are yet to be established. Here, we have reported the case of a patient with ...

    Authors: Kazutaka Oda, Hidenobu Kamohara, Tomomi Katanoda, Yumi Hashiguchi, Koji Iwamura, Kisato Nosaka, Hirofumi Jono and Hideyuki Saito

    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:15

    Content type: Case report

    Published on:

  34. There is no nationwide data on polypharmacy in palliative care in Japan. In this study, the research committee of the Japanese Society for Pharmaceutical Palliative Care and Sciences conducted an online survey...

    Authors: Mayako Uchida, Shinya Suzuki, Hideki Sugawara, Yukio Suga, Hideya Kokubun, Yoshihiro Uesawa, Takayuki Nakagawa and Hisamitsu Takase

    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:14

    Content type: Research article

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  35. Piperacillin/tazobactam (PIPC/TAZ) and cefepime (CFPM) are commonly used for the treatment of nosocomial and healthcare-associated infections. Recent reports have suggested that the incidence of acute kidney i...

    Authors: Shota Kadomura, Yoh Takekuma, Yuki Sato, Masato Sumi, Kotaro Kawamoto, Tatsuya Itoh and Mitsuru Sugawara

    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:13

    Content type: Research article

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  36. Tenofovir disoproxil fumarate (TDF) is known to reduce estimated glomerular filtration rate (eGFR). It is clinically important to identify patients at high risk for renal dysfunction as early as possible. Amon...

    Authors: Shinichi Hikasa, Shota Shimabukuro, Kyoko Hideta, Satoshi Higasa, Akihiro Sawada, Tazuko Tokugawa, Kuniyoshi Tanaka, Mina Yanai and Takeshi Kimura

    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:12

    Content type: Short report

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  37. To facilitate timely removal of urinary catheters and promote self-voiding among inpatients, urinary care teams have been established in some Japanese medical institutions. However, direct evidence of the effe...

    Authors: Takumi Umemura, Eri Wakita, Masami Asano, Takahito Mizuno, Koji Kozaki, Yoshiaki Ikeda and Hirokazu Takeda

    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:11

    Content type: Short report

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  38. Vancomycin is commonly used to treat Enterococcus faecium (E. faecium) bacteremia. However, there are very few studies on the association between the trough concentration, area under the curve from 0 to 24 h /min...

    Authors: Ichiro Nakakura, Kota Sakakura, Kaori Imanishi, Rumi Sako and Kunio Yamazaki

    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:8

    Content type: Research article

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  39. Hepatectomy is a highly invasive procedure with a high probability of postoperative delirium. Treatment with antiulcer drugs is indispensable after hepatectomy for anastomotic ulcer management. The clinical pa...

    Authors: Miho Yamasaki, Yusa Fukuda, Aika Tanimoto, Miko Narahara, Yumi Kawaguchi, Hiromi Ushiroda, Saburo Fukuda, Teruo Murakami and Yorinobu Maeda

    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:10

    Content type: Research article

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  40. Infliximab (IFX), a mouse-human chimeric monoclonal antibody against human tumor necrosis factor alpha, is used in refractory cases of Takayasu arteritis. Several factors influence the pharmacokinetics of ther...

    Authors: Sho Masui, Atsushi Yonezawa, Kazushi Izawa, Makoto Hayakari, Kayoko Asakura, Risa Taniguchi, Masahiko Isa, Hirofumi Shibata, Takahiro Yasumi, Ryuta Nishikomori, Junko Takita and Kazuo Matsubara

    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:9

    Content type: Case report

    Published on:

  41. Ritodrine hydrochloride (RD), a β2-adrenergic agonist, is widely used as a tocolytic medication to suppress premature labor, but can cause neonatal hypoglycemia, a potentially severe side effect. We examined t...

    Authors: Shoko Shimokawa, Akiko Sakata, Yukio Suga, Kazuya Isoda, Shingo Itai, Katsuhiko Nagase, Tsutomu Shimada and Yoshimichi Sai

    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:7

    Content type: Research article

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  42. Everolimus is an oral inhibitor of mammalian target of rapamycin, approved for metastatic renal cell carcinoma (mRCC). Recently, personalized medicine through therapeutic drug monitoring (TDM) is recommended i...

    Authors: Shinya Takasaki, Hiroaki Yamaguchi, Yoshihide Kawasaki, Masafumi Kikuchi, Masaki Tanaka, Akihiro Ito and Nariyasu Mano

    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:6

    Content type: Research article

    Published on:

  43. There have been debates about the association between the administration of glucocorticoids and the development of acute pancreatitis, since many anecdotal cases of this adverse event were affected either by c...

    Authors: Daisuke Nango, Yukifumi Hirose, Makoto Goto and Hirotoshi Echizen

    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:5

    Content type: Research article

    Published on:

  44. Magnesium oxide (MgO), an antacid and laxative, is widely used in Japan to treat constipation and peptic ulcers. Because serum Magnesium (Mg) levels are elevated in elderly and/or patients with renal failure, ...

    Authors: Eri Wakai, Kenji Ikemura, Hiroko Sugimoto, Takuya Iwamoto and Masahiro Okuda

    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:4

    Content type: Research article

    Published on:

  45. Medical staff should promptly administer antimicrobials to patients with febrile neutropenia (FN) to decrease the mortality related to cancer chemotherapy. Corticosteroids, which are used in cancer chemotherap...

    Authors: Hiroki Uda, Yukio Suga, Eriko Toriba, Angelina Yukiko Staub, Tsutomu Shimada, Yoshimichi Sai, Masami Kawahara and Ryo Matsusita

    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:3

    Content type: Research article

    Published on:

  46. The self-management of type 2 diabetes mellitus (T2DM), which involves adherence to medical instructions on diet and nutritional advice, physical activity, medication regimen, and weight and stress management,...

    Authors: Kana Hashimoto, Koki Urata, Ayano Yoshida, Reiko Horiuchi, Naoto Yamaaki, Kunimasa Yagi and Kunizo Arai

    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:2

    Content type: Research article

    Published on:

  47. Medication therapy management (MTM) service provides set of clinical activities to optimize therapeutic outcomes for patients. It requires the collaboration between patient, pharmacist and other healthcare pro...

    Authors: Noor Kifah Al-Tameemi and Azmi Sarriff

    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:1

    Content type: Research article

    Published on:

  48. Falls are a common but serious problem in older adults, and may lead to fractures and bleeding. As many factors, such as medication, aging, and comorbid diseases may simultaneously affect fall-related adverse ...

    Authors: Haruna Hatahira, Shiori Hasegawa, Sayaka Sasaoka, Yamato Kato, Junko Abe, Yumi Motooka, Akiho Fukuda, Misa Naganuma, Satoshi Nakao, Ririka Mukai, Kazuyo Shimada, Kouseki Hirade, Takeshi Kato and Mitsuhiro Nakamura

    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:32

    Content type: Research article

    Published on:

  49. Pharmaceutical intervention enables safe and effective pharmacotherapy by avoiding of adverse drug reactions (ADRs) and efficacy attenuations. Many prescriptions require optimization, and pharmaceutical interv...

    Authors: Yuichi Tasaka, Akihiro Tanaka, Daiki Yasunaga, Takashige Asakawa, Hiroaki Araki and Mamoru Tanaka

    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:33

    Content type: Research article

    Published on:

  50. We conducted an economic assessment using test data from the phase III TRIPLE study, which examined the efficacy of a 5-hydroxytryptamine 3 receptor antagonist as part of a standard triplet antiemetic regimen ...

    Authors: Hisanori Shimizu, Kenichi Suzuki, Takeshi Uchikura, Daiki Tsuji, Takeharu Yamanaka, Hironobu Hashimoto, Koichi Goto, Reiko Matsui, Nobuhiko Seki, Toshikazu Shimada, Shunya Ikeda, Naoki Ikegami, Toshihiro Hama, Nobuyuki Yamamoto and Tadanori Sasaki

    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:31

    Content type: Research article

    Published on:

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Journal of Pharmaceutical Health Care and Sciences

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