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  1. In the European Union (EU), a Risk Management Plan (RMP) is submitted as part of the dossier for initial marketing authorization of a medicinal product or with an application involving a significant change to ...

    Authors: Suzan Esslinger, Linda Quinn, Sami Sampat, Marijo Otero-Lobato, Wim Noël, Anja Geldhof, Nicole Herijgers and Sarah-Jane Reeder
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:14
  2. Acetaminophen-induced hypotension has been reported in critically ill patients; however, it remains unclear whether mannitol, present as a stabilizing compound in acetaminophen formulations, affects hemodynami...

    Authors: Shunsuke Inage, Ryo Yajima, Shintaro Nagahara, Aya Kazama, Moe Takamura, Tomohiro Shoji, Mika Kadoi, Yukiko Tashiro and Yuya Ise
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:13
  3. Potentially inappropriate medications (PIMs) and polypharmacy in older adults lead to increase the risk of adverse drug events. This study aimed to evaluate the effectiveness of pharmacist intervention combini...

    Authors: Takeshi Kimura, Misa Fujita, Michiko Shimizu, Kasumi Sumiyoshi, Saho Bansho, Kazuhiro Yamamoto, Tomohiro Omura and Ikuko Yano
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:12
  4. Postoperative nausea and vomiting (PONV) delays postoperative recovery, prolongs hospital stays, and hinders patients’ return to society, thus making it a major cause of increased healthcare costs. It is also ...

    Authors: Satoshi Nagase, Masaharu Imaura, Mizuki Nishimura, Kohei Takeda, Mari Takahashi, Hideki Taniguchi, Tomoyuki Sato and Hiroshi Kanno
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:11
  5. A high prevalence of mental disorders including depression, anxiety, somatoform, and dissociative disorder is reported during pregnancy, however, information on the transfer of antipsychotics across the placen...

    Authors: Jumpei Saito, Yoshiyuki Tachibana, Yuka Sano Wada, Naho Yakuwa, Hiroyo Kawasaki, Tomo Suzuki, Haruhiko Sago, Akimasa Yamatani and Atsuko Murashima
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:10
  6. We report a case of delayed excretion of methotrexate (MTX) in a pediatric patient on high-dose MTX therapy in response to a change in the concomitant dosage of voriconazole from oral to intravenous. As the in...

    Authors: Daisuke Watahiki, Daisuke Saito, Naonori Nishida, Hiroyuki Tsuri, Keiko Nomura, Yuichi Adachi and Masato Taguchi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:9
  7. The effect of pharmaceutical intervention to treat adverse events on quality of life (QOL) in outpatients receiving cancer chemotherapy is unclear. We investigated whether pharmaceutical intervention provided ...

    Authors: Hironori Fujii, Yukino Ueda, Chiemi Hirose, Koichi Ohata, Kumiko Sekiya, Mika Kitahora, Shiori Sadaka, Senri Yamamoto, Daichi Watanabe, Hiroko Kato-Hayashi, Hirotoshi Iihara, Ryo Kobayashi, Miho Kaburaki, Nobuhisa Matsuhashi, Takao Takahashi, Akitaka Makiyama…
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:8
  8. Pharmacists guide patients in their use of traditional, complementary, and integrative medicine (TCIM). The present study aimed to evaluate the opinions of Japanese pharmacists regarding TCIM, and to evaluate ...

    Authors: Yoshiharu Motoo, Keiko Yukawa, Kazuho Hisamura and Ichiro Arai
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:7
  9. Voriconazole (VRCZ) is the first-line therapy for chronic pulmonary aspergillosis and is available in both intravenous and oral formulations. The bioavailability of the oral form is estimated to be over 90% in...

    Authors: Hiromi Kaneko, Shingo Yamazaki, Masashi Uchida, Takaaki Suzuki, Kentaro Murakami, Hisahiro Matsubara, Katsuhiko Kamei and Itsuko Ishii
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:6
  10. Gemcitabine plus nab-paclitaxel (GnP) therapy is used for unresectable pancreatic ductal adenocarcinoma, but may cause interstitial lung disease (ILD) as a serious side effect. However, the risk factors for IL...

    Authors: Rikako Ueda, Naho Yamamoto, Yuki Hori, Kouji Yoshida, Koushiro Ohtsubo, Takeshi Terashima, Tsutomu Shimada and Yoshimichi Sai
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:5
  11. The blood concentration of cyclosporine (CyA) is frequently elevated following the transfusion of red blood cell concentrate (RCC) to patients after allogeneic hematopoietic stem cell transplantation (HSCT). T...

    Authors: Masashi Uchida, Natsumi Hanada, Shingo Yamazaki, Hirokazu Takatsuka, Chiaki Imai, Akari Utsumi, Yuki Shiko, Yohei Kawasaki, Takaaki Suzuki and Itsuko Ishii
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:4
  12. The standard dose of vancomycin (VCM, 2 g/day) sometimes fails to achieve therapeutic concentration in patients with normal renal function. In this study, we aimed to identify factors to predict patients who r...

    Authors: Ryo Yamaguchi, Hiroko Kani, Takehito Yamamoto, Takehiro Tanaka and Hiroshi Suzuki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:3
  13. Tracheal intubation may be performed in patients with drug overdose due to self-harm; however, the details of the causative drug are unknown. The purpose of this study was to clarify the relationship between d...

    Authors: Kazuki Nagashima, Hiroyuki Hosono and Machiko Watanabe
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:2
  14. Casirivimab-imdevimab has been developed to neutralize SARS-CoV-2. The global clinical trials in outpatients documented several adverse effects (AE), which mandate caution in Japan where part of patients retur...

    Authors: Junichi Yoshida, Kenichiro Shiraishi, Tetsuro Tamura, Kazuhiro Otani, Tetsuya Kikuchi, Akiko Mataga, Takako Ueno and Masao Tanaka
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:1
  15. Clinical pharmacists play a role in limiting the disadvantages of pharmacotherapy for patients by detecting and resolving drug-related problems (DRPs) through medication reviews. Although their contributions t...

    Authors: Toshiya Oki, Sachi Ishii, Koya Furukawa, Aiko Shono and Manabu Akazawa
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:47
  16. Human immune deficiency virus (HIV) increases the susceptibility to primary infection or reinfection and the risk of tuberculosis (TB) reactivation for patients with latent TB. There was no current report on t...

    Authors: Temesgen Mulugeta, Alazar Takale, Belachew Umeta and Behailu Terefe
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:44
  17. Zinc is an essential trace element involved in various physiological functions. In Japan, zinc acetate dihydrate is administered to neonates and infants with hypozincemia. Since serum copper concentrations are...

    Authors: Toshikazu Ito, Kazuya Uenoyama, Kazuhiro Kobayashi, Mikio Kakumoto, Hiroshi Mizumoto, Toshiya Katsura and Masahide Onoue
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:46
  18. Although clozapine is the optimal drug for patients with treatment-resistant schizophrenia, the drug has harmful adverse effects such as leukopenia. Adenine and cepharanthine are known to be effective for radi...

    Authors: Shintaro Kamei, Ryota Tanaka, Hirofumi Hirakawa, Motoshi Iwao, Rikako Kawanaka, Ryosuke Tatsuta, Takeshi Terao and Hiroki Itoh
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:45
  19. Azelnidipine, a dihydropyridine calcium channel blocker (CCB), has less adverse effects (e.g. hot flushes and reflex tachycardia) compared to other dihydropyridine CCBs. Azelnidipine has been reported to reduc...

    Authors: Naohito Ide, Ayaka Mochizuki, Yoshiyuki Kagawa and Masaharu Ito
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:48
  20. Potential drug–drug interactions (PDDIs) commonly occur because of aging and comorbidities in people living with human immunodeficiency virus (HIV; PLWH). Protease inhibitors and non-nucleoside reverse transcr...

    Authors: Yusuke Kunimoto, Ryosuke Matamura, Hiroshi Ikeda, Satoshi Fujii, Tomoko Kimyo, Manabu Kitagawa, Hiromasa Nakata, Masayoshi Kobune, Atsushi Miyamoto and Masahide Fukudo
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:43
  21. Meningitis is a common infectious cause of morbidity and mortality in pediatric age-groups. Acute bacterial meningitis is considered a medical emergency, because it is a life-threatening infection that require...

    Authors: Firomsa Bekele, Anuwar Ahmed, Abas Kedir and Tadesse Sheleme
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:41
  22. Chronic Obstructive Pulmonary Disease (COPD) is one of the prominent cause of mortality worldwide. Nowadays, the level of medication adherence in COPD patients is very low, which reduces the clinical therapeut...

    Authors: Boyuk Moradkhani, Samaneh Mollazadeh, Parastoo Niloofar, Afsaneh Bashiri and Mohammad Bagher Oghazian
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:40
  23. Therapeutic drug monitoring for voriconazole is recommended for its optimum pharmacotherapy. Although the feedback of the measurement result of serum voriconazole concentration by outsourcing needs a certain t...

    Authors: Kazutaka Oda, Shota Uchino, Kayo Kurogi, Mai Horikawa, Naoya Matsumoto, Kou Yonemaru, Hitomi Arakaki, Taiki Katsume, Kaho Matsuyama, Tomomi Katanoda, Yuki Narita, Koji Iwamura, Hirofumi Jono and Hideyuki Saito
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:42
  24. Bucolome is a non-steroidal anti-inflammatory drug and uricosuric agent, currently used only in Japan. It is known to induce drug interactions by inhibiting cytochrome P450 (CYP) 2C9. It is often used to enhan...

    Authors: Hiroki Tateishi, Daisuke Miyazu, Miho Kurinami, Ichiro Ieiri, Masaaki Hirakawa and Hiroyuki Watanabe
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:39
  25. Pharmacist plays an integral role in promoting antimicrobial stewardship (AS) strategies by committing to the evidence-based activities in this field. The present study aims to document trends in actual achiev...

    Authors: Masayuki Maeda, Takefumi Miyake, Ryo Inose, Satoru Ueda, Ken-ichi Matsugi, Yuichi Muraki and Takashi Kitahara
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:38
  26. Keeping the heart rate within the normal range has improved the survival of septic shock patients. Amiodarone could target the underlying pathophysiology of sepsis-induced tachycardia. This study aimed to dete...

    Authors: Masoud Khataminia, Farhad Najmeddin, Atabak Najafi, Hamidreza Sharifnia, Arezoo Ahmadi, Adeleh Sahebnasagh and Mojtaba Mojtahedzadeh
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:37
  27. Caffeine (0.1 g) is used as a central nervous system stimulant and as a nontoxic phenotyping probe for cytochrome P450 1A2. However, an increasing number of suicide attempts by caffeine overdose have been rece...

    Authors: Koichiro Adachi, Satoru Beppu, Mariko Terashima, Toshiaki Fukuda, Jun Tomizawa, Makiko Shimizu and Hiroshi Yamazaki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:36
  28. Clinical management of skin-toxicity associated with the use of anti-Epidermal Growth Factor Receptor (EGFR) antibodies to treat colorectal cancer maintains quality of life of patients with colorectal cancer. ...

    Authors: Munenobu Kashiwa and Ryo Matsushita
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:35
  29. Drug overdose accounts for most of the admissions to the emergency department. Prescription drugs, most of which are psychotropic medications, are often misused for drug overdose. The purpose of this study was...

    Authors: Kazuki Nagashima, Megumi Sumida, Shoichi Imanaka, Tatsuro Kuwabara, Ichiro Kaneko, Yasufumi Miyake, Nobuhiro Yasuno, Fumio Itagaki and Machiko Watanabe
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:34
  30. Loxoprofen is a propionic acid derivative and is the most widely prescribed non-steroidal anti-inflammatory drug in Japan. Loxoprofen is generally considered to be relatively nontoxic.

    Authors: Koichiro Adachi, Yuki Sugitani, Ryo Unita, Kosuke Yoshida, Satoru Beppu, Mariko Terashima, Masaya Fujii, Makiko Shimizu and Hiroshi Yamazaki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:33
  31. Clonidine hydrochloride is used to treat sedative agent withdrawals, malignant hypertension, and anesthesia complications. Clonidine is also prescribed off-label to pediatric patients at a dose of 1 μg/kg. The...

    Authors: Jumpei Saito, Takehisa Hanawa, Takahiro Matsumoto, Nozomi Yoshikawa, Tsutomu Harada, Kana Iwahashi, Hidefumi Nakamura and Akimasa Yamatani
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:31
  32. Anticholinergic burden potentially increases the risk of fracture. Although there are various anticholinergic burden scales, little is known about the inter-scale compatibility regarding the relationship of an...

    Authors: Yukari Ogawa, Toshinori Hirai and Kiyoshi Mihara
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:30
  33. The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is the most frequent cause of hyponatremia in patients with cerebrovascular disease, and is often treated with oral salt tablets. However...

    Authors: Miyuki Takemura, Yuki Tanaka, Katsuhisa Inoue, Ikumi Tamai and Yoshiyuki Shirasaka
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:29
  34. Although the over-the-counter H1 receptor antagonist diphenhydramine is not a common drug of abuse, it was recently recognized as one of the substances causing acute poisoning in patients attempting suicide that ...

    Authors: Koichiro Adachi, Satoru Beppu, Mariko Terashima, Wataru Kobari, Makiko Shimizu and Hiroshi Yamazaki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:32
  35. Currently, in Japan, shifting tasks from physician to hospital pharmacist is being developed to reduce physician workload and improve the quality of pharmacotherapy. This study aimed to investigate the effects...

    Authors: Eiji Shiwaku, Satoshi Dote, Shinobu Kaneko, Chisato Hei, Masaki Aikawa, Yuki Sakai, Takahiro Kawai, Shigeaki Iwatsubo, Michinobu Hashimoto, Teppei Tsuneishi, Tomoko Nishimura, Toshiyuki Iwata, Daiki Hira, Tomohiro Terada, Takashi Nishimura and Yuka Kobayashi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:28
  36. Cancer chemotherapy usually improves clinical outcomes in patients with advanced pancreatic cancer (APC), but can also cause moderate-to-severe adverse events (AEs). We investigated the relationship between mo...

    Authors: Hironori Fujii, Maaya Koda, Shiori Sadaka, Koichi Ohata, Hiroko Kato-Hayashi, Hirotoshi Iihara, Ryo Kobayashi, Takuma Ishihara, Shinya Uemura, Takuji Iwashita, Hideki Hayashi, Tadashi Sugiyama, Masahito Shimizu and Akio Suzuki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:27
  37. Antimicrobial stewardship (AS) is defined as coordinated interventions to improve and measure the appropriate use of antimicrobial agents. However, available resources for AS differ depending on the size of th...

    Authors: Satoshi Nakamura, Takashi Arima, Ryoichi Tashiro, Satomi Yasumizu, Hayato Aikou, Emi Watanabe, Takashi Nakashima, Yuho Nagatomo, Ikuyo Kakimoto and Toshiro Motoya
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:25
  38. A chemopreventive effect of low-dose aspirin against colorectal tumors was previously found in participants of two Japanese multicenter, double-blind, randomized, placebo-controlled clinical trials investigati...

    Authors: Hiroshi Yamazaki, Makiko Shimizu, Takahiro Otani, Ami Mizugaki, Kanae Mure, Sadao Suzuki and Hideki Ishikawa
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:26
  39. Irinotecan (CPT-11) is clinically known to cause severe diarrhea and gastrointestinal damage. Recently, we have reported that CPT-11-induced gastrointestinal damage is associated with the upregulation of intes...

    Authors: Toshiaki Tsuchitani, Takeshi Akiyoshi, Ayuko Imaoka and Hisakazu Ohtani
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:24
  40. A multicenter investigation of neonate exposure to potentially harmful excipients (PHEs) in neonatal intensive care units (NICUs) in Japan has not been conducted.

    Authors: Jumpei Saito, Naomi Nadatani, Makoto Setoguchi, Masahiko Nakao, Hitomi Kimura, Mayuri Sameshima, Keiko Kobayashi, Hiroaki Matsumoto, Naoki Yoshikawa, Toshihiro Yokoyama, Hitomi Takahashi, Mei Suenaga, Ran Watanabe, Kinuko Imai, Mami Obara, Mari Hashimoto…
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:23
  41. Renal function and use of concomitant medications should be carefully monitored in patients subjected to treatment with direct oral anticoagulants (DOACs); the dose should be individually designed for each pat...

    Authors: Naoto Ishikawa, Hanae Oshikiri, Shinya Takasaki, Masafumi Kikuchi, Taku Obara, Kazutoshi Akasaka, Masaki Matsuura, Hiroaki Yamaguchi and Nariyasu Mano
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:22
  42. Recently, aprepitant has been recommended in carboplatin-based regimens, but there are limited reports on the efficacy of administering aprepitant, palonosetron, and dexamethasone (DEX) in carboplatin-containi...

    Authors: Yuko Watanabe, Yoshitaka Saito, Takashi Mitamura, Yoh Takekuma and Mitsuru Sugawara
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:21
  43. Neonatal populations are quite susceptible to drug-related problems (DRPs) because of clinical heterogeneity and clinical practice trends. However, studies reporting DRPs in the neonatal population are quite l...

    Authors: Mengist Awoke, Tsegaye Melaku and Mohammed Beshir
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:20
  44. In clinical practice, a mixed suspension of clopidogrel bisulfate and magnesium oxide (MgO) tablets is administered frequently via a feeding tube. However, there is no report on the changes occurring when susp...

    Authors: Manahito Aoki, Midori Naya, Shiho Arima, Kaori Shinohara, Masahiro Kato, Kiyoshi Shibuya, Masaki Ohtawa, Tohru Nagamitsu and Katsuya Otori
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:18
  45. Primary angle closure disease (PACD) is a type of glaucoma in which the intraocular pressure (IOP) is increased because of the blockage of the anterior chamber angle. Medications contraindicated for patients w...

    Authors: Fumiaki Tanaka, Naoki Shibatani, Kazumi Fujita, Hiroaki Ikesue, Satoru Yoshimizu, Nobuyuki Muroi, Yasuo Kurimoto and Tohru Hashida
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:17
  46. Frailty is an urgent concern among an aging population worldwide. However, the relationship between frailty and number and types of medications has not been studied in detail among early-stage older patients, ...

    Authors: Yuya Uragami, Kazuhiro Takikawa, Hajime Kareki, Koji Kimura, Kazuyuki Yamamoto and Naomi Iihara
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:15
  47. Several studies have reported the implementation of nutrition therapy and rehabilitation for acute and critical illnesses. However, rehabilitation nutrition for elderly sarcopenia patients with extremely sever...

    Authors: Michiyo Tatsumi, Satomi Kumagai, Takahiro Abe, Soichi Murakami, Hiroshi Takeda, Toshiaki Shichinohe, Yuko Watanabe, Shinsuke Katayama, Shiaki Hirai, Aiko Honda, Yoh Takekuma and Mitsuru Sugawara
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:16
  48. Drug shortage is a significant public health problem, especially for drugs related to life threatening conditions. Almost all countries affected by variety of supply problems and spent a considerable amount of...

    Authors: Asiye Moosivand, Maryam Rangchian, Leila Zarei, Farzad Peiravian, Gholamhossein Mehralian and Hesameddin Sharifnia
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:14
  49. The recognition, prevention and treatment of venous thromboembolism (VTE) remains a major challenge in the face of the recent COVID-19 pandemic which has been associated with significant cardiovascular, renal,...

    Authors: Laura Gillespie, Rashid Z. Khan, John E. Stillson, Connor M. Bunch, Faisal Salim Shariff, Jacob Speybroeck, Anne Grisoli, Meredith Wierman Schmidt, Htay Phyu, Jason Jablonski, Byars Wells, Daniel H. Fulkerson, Lyndsay Oancea, Abraham Leiser and Mark Walsh
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:19
  50. Migraine is a painful and disabling nervous disorder which negatively affects the quality of life. Migraineurs may suffer from a generalized vasomotor dysfunction. Statins improve vasomotor and vascular functi...

    Authors: Reza Ganji, Nastaran Majdinasab, Saeed Hesam, Nazanin Rostami, Mehdi Sayyah and Adeleh Sahebnasagh
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:12

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