Table 2 Hypothesis testing for fixed effect model of digoxin pharmacokinetics

CL=θ1

−128.969

θ1+θ2×CLcr

−331.151

202.182

<0.001

θ1+θ2×BW

−139.203

10.234

<0.002

θ1×θ2^{Ejection function} (EF>41=1,EF<40=0)

−129.247

0.278

N.S.

θ1×θ2^Age (Age>65=0,Age<64=1)

−131.508

2.539

N.S.

θ1×θ2^Drug (0;Cocomitant adminstaraion,1;otherwise)

Amiodarone

−163.260

34.291

<0.001

Amlodipine

−142.552

13.583

<0.001

Atorvastatin

−135.985

7.016

<0.01

Azelnidipine

−129.016

0.047

N.S.

Bisoprolol

−145.971

17.002

<0.001

Carvedilol

−134.190

5.221

<0.05

Nifedipine

−129.355

0.386

N.S.

Spironolactone

−132.177

3.208

N.S.

Tolvaptan

−133.804

4.835

<0.05

Antiarrhythmic agent;Class I (Aprindine,Cibenzoline, Flecainide,Pilsicainde,Procainamide)

−131.664

2.695

N.S.

Antiarrhythmic agent;Class IV (Bepridil,Diltiazem,Verapamil)

−131.559

2.590

N.S.