| |
Basic model
|
Final model
|
|---|
|
CL (L/h) = θ1
|
CL (L/h) = θ1 × CLcr (mL/min)
|
|---|
|
Vd (L) = θ2
|
Vd (L) = θ2
|
|---|
|
Parameter
|
Mean
|
95 % CI
|
Mean
|
95 % CI
|
|
θ1
|
8.09
|
6.75–9.42
|
0.21
|
0.173–0.246
|
|
θ2
|
39.1
|
34.0–44.2
|
28.9
|
24.0–33.7
|
|
Interindividual variability
| | | |
|
ηCL
|
0.765
|
0.465–1.065
|
0.0835
|
0.0292–0.137
|
|
ηvd
|
0.217
|
0.135–0.298
|
0.104
|
0.094–0.115
|
|
Residual variability
| | | | |
|
ε
|
0.0643
|
0.0306–0.0979
|
0.0304
|
0.0269–0.0334
|
- η, random variable, which is normally distributed with mean 0 and variance ω2
- ε, random error, which is normally distributed with mean 0 and variance σ2
-
CI confidence interval, CLcr creatinine clearance
