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Table 4 Summary of results for the basic and final population models

From: Population pharmacokinetic analysis and dosing regimen optimization of penicillin G in patients with infective endocarditis

  Basic model Final model
CL (L/h) = θ1 CL (L/h) = θ1 × CLcr (mL/min)
Vd (L) = θ2 Vd (L) = θ2
Parameter Mean 95 % CI Mean 95 % CI
θ1 8.09 6.75–9.42 0.21 0.173–0.246
θ2 39.1 34.0–44.2 28.9 24.0–33.7
Interindividual variability    
ηCL 0.765 0.465–1.065 0.0835 0.0292–0.137
ηvd 0.217 0.135–0.298 0.104 0.094–0.115
Residual variability     
ε 0.0643 0.0306–0.0979 0.0304 0.0269–0.0334
  1. η, random variable, which is normally distributed with mean 0 and variance ω2
  2. ε, random error, which is normally distributed with mean 0 and variance σ2
  3. CI confidence interval, CLcr creatinine clearance