Population pharmacokinetic analysis and dosing regimen optimization of penicillin G in patients with infective endocarditis

Table 4 Summary of results for the basic and final population models

	Basic model		Final model
	CL (L/h) = θ1		CL (L/h) = θ1 × CLcr (mL/min)
	Vd (L) = θ2		Vd (L) = θ2
Parameter	Mean	95 % CI	Mean	95 % CI
θ1	8.09	6.75–9.42	0.21	0.173–0.246
θ2	39.1	34.0–44.2	28.9	24.0–33.7
Interindividual variability
η_CL	0.765	0.465–1.065	0.0835	0.0292–0.137
ηvd	0.217	0.135–0.298	0.104	0.094–0.115
Residual variability
ε	0.0643	0.0306–0.0979	0.0304	0.0269–0.0334

ISSN: 2055-0294