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Table 2 Pharmacokinetics of mianserin after a single administration to healthy male subjects

From: The pharmacokinetics of mianserin suppositories for rectal administration in dogs and healthy volunteers: a pilot study

 

tmax (h)

Cmax (ng/mL)

AUC0-24 (h • ng/mL)

AUC (h • ng/mL)

Suppository (30 mg)

8a)

14.6 ± 6.3a)

266 ± 103a)

541.8 ± 189.4a)

Oral tablets (30 mg)

2.0 ± 0.1b)

40.7 ± 2.6b)

338.5c)

435.4 ± 35.3b)

  1. a) The present study data, expressed as mean ± SD, n = 3
  2. b) Data derived from the package insert of Tetramide® Tablets
  3. c) Values estimated from the plasma concentration profile in the Tetramide® Tablet package insert