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Table 2 Pharmacokinetics of mianserin after a single administration to healthy male subjects

From: The pharmacokinetics of mianserin suppositories for rectal administration in dogs and healthy volunteers: a pilot study

  tmax (h) Cmax (ng/mL) AUC0-24 (h • ng/mL) AUC (h • ng/mL)
Suppository (30 mg) 8a) 14.6 ± 6.3a) 266 ± 103a) 541.8 ± 189.4a)
Oral tablets (30 mg) 2.0 ± 0.1b) 40.7 ± 2.6b) 338.5c) 435.4 ± 35.3b)
  1. a) The present study data, expressed as mean ± SD, n = 3
  2. b) Data derived from the package insert of Tetramide® Tablets
  3. c) Values estimated from the plasma concentration profile in the Tetramide® Tablet package insert