Analysis of Stevens-Johnson syndrome and toxic epidermal necrolysis using the Japanese Adverse Drug Event Report database

Table 1 SJS/TEN in the Japanese Adverse Drug Event Report database (April 2004–April 2015)

	Gender	Total			Allopurinol			Loxoprofen			Acetaminophen			Carbamazepine			Lamotrigine
		Reported cases		Reporting ratio (%)	Reported cases		Reporting ratio (%)	Reported cases		Reporting ratio (%)	Reported cases		Reporting ratio (%)	Reported cases		Reporting ratio (%)	Reported cases		Reporting ratio (%)
		SJS or TEN	Total	Reporting ratio (%)	SJS or TEN	Total	Reporting ratio (%)	SJS or TEN	Total	Reporting ratio (%)	SJS or TEN	Total	Reporting ratio (%)	SJS or TEN	Total	Reporting ratio (%)	SJS or TEN	Total	Reporting ratio (%)
Total		6568	353988	1.86	544	2642	20.59	525	4714	11.14	498	1925	25.87	420	4517	9.30	403	2375	16.97
Stratified by age^a
≤19 years	M	388	12982	2.99	1	9	11.11	14	69	20.29	87	325	26.77	35	345	10.14	3	76	3.95
	F	295	12088	2.44	0	7	0.00	12	80	15.00	83	262	31.68	17	265	6.42	17	144	11.81
20-39 years	M	470	13842	3.40	22	98	22.45	89	368	24.18	32	129	24.81	41	369	11.11	32	191	16.75
	F	791	20302	3.90	11	39	28.21	100	555	18.02	101	298	33.89	54	481	11.23	82	554	14.80
40-59 years	M	723	36749	1.97	80	454	17.62	60	606	9.90	33	155	21.29	40	630	6.35	60	318	18.87
	F	796	36347	2.19	39	126	30.95	90	631	14.26	58	205	28.29	49	495	9.90	76	331	22.96
60-79 years	M	1192	86098	1.38	154	902	17.07	88	991	8.88	45	218	20.64	77	761	10.12	25	170	14.71
	F	1099	71275	1.54	106	420	25.24	53	889	5.96	45	198	22.73	76	569	13.36	53	251	21.12
≥80 years	M	227	18393	1.23	35	218	16.06	6	169	3.55	3	39	7.69	5	121	4.13	10	27	37.04
	F	383	22610	1.69	89	266	33.46	9	300	3.00	8	66	12.12	10	153	6.54	6	39	15.38
Subtotal		6364	330686	1.92	537	2539	21.15	521	4658	11.19	495	1895	26.12	404	4189	9.64	364	2101	17.33

ISSN: 2055-0294