Skip to main content

Table 3 Quantitative evaluation of the simulated INR transitions corresponding to Figs. 5 and 6

From: Effect of vitamin K2 on the anticoagulant activity of warfarin during the perioperative period of catheter ablation: Population analysis of retrospective clinical data

(A) Effect of renal function on INR transitions.
Renal Function Normal Decreased renal function
Vitamin K2 (mg) 0 20 40 60 0 20 40 60
ΔINR (×10−1) 1.30 3.02 3.41 3.58 2.15 5.11 5.73 5.98
1st Loading (×10−1) 0.72 0.40 0.23 0.15 1.12 0.55 0.30 0.17
95 % Recovery (h) 8 100 148 172 16 126 174 200
INR/day (×10−1) 3.90 0.72 0.55 0.50 3.23 0.97 0.79 0.72
(B) Effects of combinations of various warfarin maintenance doses and vitamin K2 doses on INR transitions.
Warfarin (mg) 3 4
Vitamin K2 (mg) 0 20 40 60 0 20 40 60
ΔINR (×10−1) 1.30 3.02 3.41 3.58 1.75 4.10 4.62 4.83
1st Loading (×10−1) 0.72 0.40 0.23 0.15 0.77 0.38 0.20 0.11
95 % Recovery (h) 8 100 148 172 26 126 172 196
INR/day (×10−1) 3.90 0.72 0.55 0.50 1.62 0.78 0.64 0.59
Warfarin (mg) 5 6
Vitamin K2 (mg) 0 20 40 60 0 20 40 60
ΔINR (×10−1) 2.21 5.26 5.90 6.16 2.66 6.49 7.24 7.54
1st Loading (×10−1) 0.83 0.38 0.17 0.08 0.89 0.38 0.15 0.05
95 % Recovery (h) 28 150 196 206 32 158 200 224
INR/day (×10−1) 1.89 0.84 0.72 0.72 2.00 0.99 0.87 0.81
(C) Effect of interindividual variability on INR transitions.
  ks IC 50 k 30
  0 0 0
ΔINR (×10−1) 2.37 3.02 4.16 2.20 3.02 5.04 2.94 3.02 3.10
1st Loading (×10−1) 0.31 0.40 0.55 0.31 0.40 0.54 0.55 0.40 0.26
95 % Recovery (h) 82 100 102 76 100 126 58 100 198
INR/day (×10−1) 0.69 0.72 0.98 0.69 0.72 0.96 1.22 0.72 0.38
  1. ∆INR, a decrease before and after warfarin withdrawal; 1st Loading, an INR increase by the first warfarin loading; 95 % Recovery, a time to elevate to the 95 % of the INR value before warfarin withdrawal; INR/day, ∆INR divided by 95 % Recovery