Effect of vitamin K2 on the anticoagulant activity of warfarin during the perioperative period of catheter ablation: Population analysis of retrospective clinical data

Table 3 Quantitative evaluation of the simulated INR transitions corresponding to Figs. 5 and 6

(A) Effect of renal function on INR transitions.
Renal Function	Normal					Decreased renal function
Vitamin K₂ (mg)	0	20		40	60	0	20	40	60
ΔINR (×10⁻¹)	1.30	3.02		3.41	3.58	2.15	5.11	5.73	5.98
1st Loading (×10⁻¹)	0.72	0.40		0.23	0.15	1.12	0.55	0.30	0.17
95 % Recovery (h)	8	100		148	172	16	126	174	200
INR/day (×10⁻¹)	3.90	0.72		0.55	0.50	3.23	0.97	0.79	0.72
(B) Effects of combinations of various warfarin maintenance doses and vitamin K₂ doses on INR transitions.
Warfarin (mg)	3					4
Vitamin K₂ (mg)	0	20		40	60	0	20	40	60
ΔINR (×10⁻¹)	1.30	3.02		3.41	3.58	1.75	4.10	4.62	4.83
1st Loading (×10⁻¹)	0.72	0.40		0.23	0.15	0.77	0.38	0.20	0.11
95 % Recovery (h)	8	100		148	172	26	126	172	196
INR/day (×10⁻¹)	3.90	0.72		0.55	0.50	1.62	0.78	0.64	0.59
Warfarin (mg)	5					6
Vitamin K₂ (mg)	0	20		40	60	0	20	40	60
ΔINR (×10⁻¹)	2.21	5.26		5.90	6.16	2.66	6.49	7.24	7.54
1st Loading (×10⁻¹)	0.83	0.38		0.17	0.08	0.89	0.38	0.15	0.05
95 % Recovery (h)	28	150		196	206	32	158	200	224
INR/day (×10⁻¹)	1.89	0.84		0.72	0.72	2.00	0.99	0.87	0.81
(C) Effect of interindividual variability on INR transitions.
	ks			IC ₅₀			k ₃₀
	+ω	0	-ω	+ω	0	-ω	+ω	0	-ω
ΔINR (×10⁻¹)	2.37	3.02	4.16	2.20	3.02	5.04	2.94	3.02	3.10
1st Loading (×10⁻¹)	0.31	0.40	0.55	0.31	0.40	0.54	0.55	0.40	0.26
95 % Recovery (h)	82	100	102	76	100	126	58	100	198
INR/day (×10⁻¹)	0.69	0.72	0.98	0.69	0.72	0.96	1.22	0.72	0.38

∆INR, a decrease before and after warfarin withdrawal; 1st Loading, an INR increase by the first warfarin loading; 95 % Recovery, a time to elevate to the 95 % of the INR value before warfarin withdrawal; INR/day, ∆INR divided by 95 % Recovery

ISSN: 2055-0294