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Fig. 2 | Journal of Pharmaceutical Health Care and Sciences

Fig. 2

From: Validated determination method of tramadol and its desmethylates in human plasma using an isocratic LC-MS/MS and its clinical application to patients with cancer pain or non-cancer pain

Fig. 2

MS/MS chromatograms of human drug-free plasma (a), human drug-free plasma spiked with 200 ng/mL tramadol, 40 ng/mL O-desmethylate, 40 ng/mL N-desmethylate, and 40 ng/mL N,O-didesmethylate, (b) a plasma specimen at 8 h after evening dosing in cancer pain (c) and non-cancer pain (d) patients treated with oral tramadol. (1) Tramadol, (2) O-desmethylate, (3) N-desmethylate, (4) N,O-didesmethylate, and (5) tramadol-d6 as internal standard

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Journal of Pharmaceutical Health Care and Sciences

ISSN: 2055-0294

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