Checklist of appropriate prescriptions | Ambulant patients (n = 131) | Inpatients (n = 97) | P value |
---|---|---|---|
Overall (%) | 43 (33) | 11 (11) | <0.001 |
Unauthorized indication | 0 | 0 | NA |
Violation of contraindications | |||
eGFR < 30 mL/min/1.73 m2 | 0 [0] | 0 [0] | NA |
CLCr < 30 mL/min | 2 [50] | 0 [80] | 0.15 |
Concomitant use with oral itraconazole | 0 | 0 | NA |
Active bleeding or hemorrhagic diathesis | 0 | 0 | NA |
History of complications associated with high-risk of bleeding (cerebral hemorrhage) in the latest 6 months | 0 | 0 | NA |
Concomitant dwelling of spinal or epidural catheters | 0 | 0 | NA |
History of serious hypersensitivity reaction to Prazaxa® | 0 | 0 | NA |
Inappropriate dose selection in reference to age | |||
Overdose for patients ≥ 70 years (%) | 14/77 (18) | 2/56 (4) | <0.05 |
Underdose for patients ≥ 70 years (%) | 2/77 (3) | 1/56 (2) | NS |
Overdose for patients < 70 years (%) | 0/54 (0) | 0/41 (0) | NA |
Underdose for patients < 70 years (%) | 3/54 (6) | 0/41 (0) | NS |
Non-compliance with the recommendations for dose reduction | |||
eGFR from 30 to 50 mL/min/1.73 m2 (%) | 2/22 (9) | 1/10 (10) | NS |
CLcr from 30 to 50 mL/min | 0/11 (0) | 1/15 (7) | NS |
Past medical history of gastrointestinal bleeding (%) | 1/5 (20) | 3/5 (60) | NS |
Concomitant use of verapamil (%) | 7/10 (70) | 3/7 (43) | NS |
No assessment of renal function (%) | 1/131 (1) | 0/97 (0) | NS |
PT-INR < 2.0 when dabigatran was started after discontinuation of warfarin | 14/54 (26) | 1/21 (5) | 0.053 |