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Table 3 Health foods with inhibitory activity and residual activity of P450s

From: Effect of health foods on cytochrome P450-mediated drug metabolism

Product classification Numbera Product name Inhibited P450 Relative activity (%)b
CYP1A2 CYP2C9 CYP2C19 CYP2D6 CYP3A4
Vitamin 4/19 Vitamin-4 CYP2C9 73.0 8.6 62.8 64.0
Vitamin-11 CYP2C9 95.1 18.1 65.4
Vitamin-13 CYP2C9 92.4 23.3 88.1 65.3
Vitamin-15 CYP1A2, CYP2C9 38.2 7.3 62.6 72.6
Glucosamine 2/11 Glucosamine-27 CYP1A2 45.1 83.6 92.4 65.6 56.2
Glucosamine-28 CYP1A2 36.4 70.0 70.2 50.7 53.2
Collagen 3/12 Collagen-29 CYP2C9 96.1 31.8 81.4 71.4
Collagen-36 CYP2C9, CYP2D6, CYP3A4 61.4 27.7 69.1 46.2 42.2
Collagen-152 CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4 26.3 8.0 30.4 35.6 26.6
Mineral 1/14 Mineral-39 CYP2C9 52.3 41.5 70.1
Plant 1/6 Plant-57 CYP2C9 58.1 28.4 63.6 63.5 98.3
Isoflavone 1/10 Isoflavone-62 CYP1A2, CYP2C9 35.7 8.5 97.4 75.0
Diet 6/9 Diet-65 CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4 22.3 3.8 32.4 34.7 23.9
Diet-66 CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4 24.2 3.4 20.4 19.7 17.1
Diet-67 CYP2C9 76.5 44.3 77.6 55.1
Diet-68 CYP2C9 77.4 46.3 99.1 75.8 55.3
Diet-69 CYP2C9 94.7 48.5 68.2 60.0
Diet-70 CYP1A2, CYP2C9, CYP3A4 49.1 19.0 68.4 65.3 40.2
Garlic 1/10 Garlic-160 CYP1A2 45.2 77.3 53.4 56.3
Lutein/berry 0/11
Aojiru 0/10
Amino acid 0/6
Chlorella 0/7
Lactic acid bacterium 0/5
Other 1/3 Other-168 CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4 7.6 5.3 0.0 20.9 32.5
Oyster 0/3
Vinegar 1/6 Vinegar-169 CYP2C9 46.4 70.8 83.9 59.6
CoQ10 0/4
Turmeric 3/4 Turmeric-124 CYP1A2, CYP2C9, CYP3A4 47.2 49.4 67.6 66.4 30.2
Turmeric-125 CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4 19.2 5.6 10.2 35.4 25.1
Turmeric-126 CYP1A2 18.3 70.9 85.7 61.8 57.8
DHA 0/3
Vitamin/mineral 2/3 Vitamin/mineral-131 CYP1A2, CYP2C9 49.2 7.3 89.6 71.7 59.0
Vitamin/mineral-133 CYP2C9 28.4 71.5
Enzyme 1/1 Enzyme-134 CYP2D6 94.6 36.6 62.5
Sesamin 3/3 Sesamin-135 CYP2C9, CYP2C19, CYP2D6, CYP3A4 56.8 12.5 25.6 31.5 31.4
Sesamin-136 CYP2C9, CYP2C19, CYP2D6, CYP3A4 58.5 15.7 32.4 43.4 31.0
Sesamin-172 CYP2C9 83.0 49.4 62.8 57.3 51.1
Vegetable 1/3 Vegetable-139 CYP1A2 36.8 86.8 97.4 71.5
Royal jelly 0/3
Animal 1/1 Animal-143 CYP2C9 88.5 24.6 88.6 61.5
Tea 0/1
SJW 2/2 SJW-145 CYP1A2, CYP2C9, CYP3A4 26.5 31.3 78.0 57.0 32.5
SJW-146 CYP1A2, CYP2C9, CYP3A4 21.4 22.3 64.3 53.8 29.9
α-Lipoic acid 0/2
  1. aNumber of products with inhibitory activity/Number of products examined
  2. bP450s that were not inhibited by products are shown as ―