Table 3 Health foods with inhibitory activity and residual activity of P450s
From: Effect of health foods on cytochrome P450-mediated drug metabolism
Product classification | Numbera | Product name | Inhibited P450 | Relative activity (%)b | ||||
|---|---|---|---|---|---|---|---|---|
CYP1A2 | CYP2C9 | CYP2C19 | CYP2D6 | CYP3A4 | ||||
Vitamin | 4/19 | Vitamin-4 | CYP2C9 | 73.0 | 8.6 | ― | 62.8 | 64.0 |
Vitamin-11 | CYP2C9 | 95.1 | 18.1 | ― | ― | 65.4 | ||
Vitamin-13 | CYP2C9 | 92.4 | 23.3 | ― | 88.1 | 65.3 | ||
Vitamin-15 | CYP1A2, CYP2C9 | 38.2 | 7.3 | ― | 62.6 | 72.6 | ||
Glucosamine | 2/11 | Glucosamine-27 | CYP1A2 | 45.1 | 83.6 | 92.4 | 65.6 | 56.2 |
Glucosamine-28 | CYP1A2 | 36.4 | 70.0 | 70.2 | 50.7 | 53.2 | ||
Collagen | 3/12 | Collagen-29 | CYP2C9 | 96.1 | 31.8 | ― | 81.4 | 71.4 |
Collagen-36 | CYP2C9, CYP2D6, CYP3A4 | 61.4 | 27.7 | 69.1 | 46.2 | 42.2 | ||
Collagen-152 | CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4 | 26.3 | 8.0 | 30.4 | 35.6 | 26.6 | ||
Mineral | 1/14 | Mineral-39 | CYP2C9 | 52.3 | 41.5 | ― | ― | 70.1 |
Plant | 1/6 | Plant-57 | CYP2C9 | 58.1 | 28.4 | 63.6 | 63.5 | 98.3 |
Isoflavone | 1/10 | Isoflavone-62 | CYP1A2, CYP2C9 | 35.7 | 8.5 | ― | 97.4 | 75.0 |
Diet | 6/9 | Diet-65 | CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4 | 22.3 | 3.8 | 32.4 | 34.7 | 23.9 |
Diet-66 | CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4 | 24.2 | 3.4 | 20.4 | 19.7 | 17.1 | ||
Diet-67 | CYP2C9 | 76.5 | 44.3 | ― | 77.6 | 55.1 | ||
Diet-68 | CYP2C9 | 77.4 | 46.3 | 99.1 | 75.8 | 55.3 | ||
Diet-69 | CYP2C9 | 94.7 | 48.5 | ― | 68.2 | 60.0 | ||
Diet-70 | CYP1A2, CYP2C9, CYP3A4 | 49.1 | 19.0 | 68.4 | 65.3 | 40.2 | ||
Garlic | 1/10 | Garlic-160 | CYP1A2 | 45.2 | 77.3 | ― | 53.4 | 56.3 |
Lutein/berry | 0/11 | ― | ― | ― | ― | ― | ― | ― |
Aojiru | 0/10 | ― | ― | ― | ― | ― | ― | ― |
Amino acid | 0/6 | ― | ― | ― | ― | ― | ― | ― |
Chlorella | 0/7 | ― | ― | ― | ― | ― | ― | ― |
Lactic acid bacterium | 0/5 | ― | ― | ― | ― | ― | ― | ― |
Other | 1/3 | Other-168 | CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4 | 7.6 | 5.3 | 0.0 | 20.9 | 32.5 |
Oyster | 0/3 | ― | ― | ― | ― | ― | ― | ― |
Vinegar | 1/6 | Vinegar-169 | CYP2C9 | ― | 46.4 | 70.8 | 83.9 | 59.6 |
CoQ10 | 0/4 | ― | ― | ― | ― | ― | ― | ― |
Turmeric | 3/4 | Turmeric-124 | CYP1A2, CYP2C9, CYP3A4 | 47.2 | 49.4 | 67.6 | 66.4 | 30.2 |
Turmeric-125 | CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4 | 19.2 | 5.6 | 10.2 | 35.4 | 25.1 | ||
Turmeric-126 | CYP1A2 | 18.3 | 70.9 | 85.7 | 61.8 | 57.8 | ||
DHA | 0/3 | ― | ― | ― | ― | ― | ― | ― |
Vitamin/mineral | 2/3 | Vitamin/mineral-131 | CYP1A2, CYP2C9 | 49.2 | 7.3 | 89.6 | 71.7 | 59.0 |
Vitamin/mineral-133 | CYP2C9 | ― | 28.4 | ― | ― | 71.5 | ||
Enzyme | 1/1 | Enzyme-134 | CYP2D6 | ― | 94.6 | ― | 36.6 | 62.5 |
Sesamin | 3/3 | Sesamin-135 | CYP2C9, CYP2C19, CYP2D6, CYP3A4 | 56.8 | 12.5 | 25.6 | 31.5 | 31.4 |
Sesamin-136 | CYP2C9, CYP2C19, CYP2D6, CYP3A4 | 58.5 | 15.7 | 32.4 | 43.4 | 31.0 | ||
Sesamin-172 | CYP2C9 | 83.0 | 49.4 | 62.8 | 57.3 | 51.1 | ||
Vegetable | 1/3 | Vegetable-139 | CYP1A2 | 36.8 | 86.8 | 97.4 | ― | 71.5 |
Royal jelly | 0/3 | ― | ― | ― | ― | ― | ― | ― |
Animal | 1/1 | Animal-143 | CYP2C9 | 88.5 | 24.6 | ― | 88.6 | 61.5 |
Tea | 0/1 | ― | ― | ― | ― | ― | ― | ― |
SJW | 2/2 | SJW-145 | CYP1A2, CYP2C9, CYP3A4 | 26.5 | 31.3 | 78.0 | 57.0 | 32.5 |
SJW-146 | CYP1A2, CYP2C9, CYP3A4 | 21.4 | 22.3 | 64.3 | 53.8 | 29.9 | ||
α-Lipoic acid | 0/2 | ― | ― | ― | ― | ― | ― | ― |