Safety of human papillomavirus vaccines in healthy young women: a meta-analysis of 24 controlled studies

Table 3 Pooled risk ratios of grade 3 solicited local symptoms

Comparison	Studies, n	Subjects, n	Pooled RR [95% CI]	Reference
Pain
2vHPV vaccine vs Hepatitis vaccine^a	3	13,237	4.49 [3.02, 6.68]	[34, 37, 41]
2vHPV vaccine vs Placebo	2	645	6.58 [3.03, 4.30]	[27, 40]
Redness
2vHPV vaccine vs Hepatitis vaccine^a	3	13,237	6.30 [1.97, 20.16]	[34, 37, 41]
2vHPV vaccine vs Placebo	2	645	1.62 [0.20, 13.07]	[27, 40]
Swelling
2vHPV vaccine vs Hepatitis vaccine^a	3	13,237	5.04 [3.21, 7.91]	[34, 37, 41]
2vHPV vaccine vs Placebo	2	645	2.52 [0.58, 10.97]	[27, 40]

Grade 3 solicited local symptoms define as pain that prevents normal activity, and redness or swelling at the injection site with a diameter greater than 50 mm
Abbreviations: HPV human papillomavirus, 2vHPV bivalent human papillomavirus, RR risk ratio, CI confidence interval
^aAll studies [27, 34, 37, 40, 41] used hepatitis A as control

ISSN: 2055-0294