Table 1 MPA concentration measured by PETINIA and LC-MS/MS by sampling times
Sampling Time (h) | Number | MPA Concentration Measured by PETINIA, Mean ± SD (μg/mL) | MPA Concentration Measured by LC-MS/MS, Mean ± SD (μg/mL) | Wilcoxon signed rank test |
0 | 20 | 1.89±1.35 | 1.46±1.05 | P < 0.0001 |
0.5 | 20 | 3.24±3.02 | 2.82±3.07 | P < 0.0001 |
2 | 20 | 4.64±2.87 | 4.17±2.91 | P = 0.0024 |
0, 0.5, 2 | 60 | 3.26±2.73 | 2.82±2.71 | P < 0.0001 |
Sampling Time (h) | Passing–Bablok | Bland–Altman | ||
Slope (95% CI) | Intercept (95% CI) | Bias (95% CI) (μg/mL) | Bias (95% CI) (%) | |
0 | 1.242 (1.131–1.392) | 0.054 (− 0.139–0.193) | 0.44 (0.27–0.60) | 31.83 (24.37–39.28) |
0.5 | 1.014 (0.944–1.153) | 0.306 (0.141–0.483) | 0.42 (0.25–0.59) | 28.19 (18.31–38.06) |
2 | 1.044 (0.920–1.126) | 0.417 (0.185–0.692) | 0.47 (0.17–0.78) | 18.54 (10.69–26.40) |
0, 0.5, 2 | 1.104 (1.036–1.150) | 0.229 (0.144–0.315) | 0.44 (0.32–0.56) | 26.25 (21.43–31.07) |