Fig. 1

Relationship between systemic fluconazole clearance (CL) and postmenstrual age (PMA) in neonates and infants (a) and between fluconazole CL and age in children aged older than 5 years and adults (b). In the inset of A, the data in infants are plotted on a magnified ordinate scale for better visibility. The area of each symbol (○) is in proportion to the number of dataset. There is a significant correlation between fluconazole CL and PMA in infants (Y = 0.093X - 2.45, r = 0.81, p < 0.001), and between fluconazole CL and age in young children and adults (Y = 0.154X + 14.74, r = 0.36, p < 0.005). Solid lines represent the least square regression lines. Bold dotted lines represent the upper and lower 95% confidence intervals of the regression lines. Fine dotted lines represent the 95% confidence intervals of the datasets. Note that the scales of the abscissae are different in (a) and (b). No data were available for children aged between PMA 60 weeks and 5 years