Impact of pharmacist counseling on reducing instances of adverse events that can affect the quality of life of chemotherapy outpatients with breast Cancer

Tanaka, Kazuhide; Hori, Akiyo; Tachi, Tomoya; Osawa, Tomohiro; Nagaya, Katsuhiro; Makino, Teppei; Inoue, Seiji; Yasuda, Masahiro; Mizui, Takashi; Nakada, Takumi; Goto, Chitoshi; Teramachi, Hitomi

doi:10.1186/s40780-018-0105-3

Journal of Pharmaceutical Health Care and Sciences

Table 5 Comparison of the QOL-ACD total score and mean score for each subscale before 1st and 3rd course in patients with adverse events of both groups

From: Impact of pharmacist counseling on reducing instances of adverse events that can affect the quality of life of chemotherapy outpatients with breast Cancer

			Total score				Subscale
Adverse event	Existence of intervention	n	Before 1st course	Before 3rd course	Difference	P	Activity			P	Physical condition			P	Psychological condition			P	Social relationships			P
			Before 1st course	Before 3rd course	Difference		Before 1st course	Before 3rd course	Difference		Before 1st course	Before 3rd course	Difference		Before 1st course	Before 3rd course	Difference		Before 1st course	Before 3rd course	Difference
			(A)	(C)	(C-A)		(A)	(C)	(C-A)		(A)	(C)	(C-A)		(A)	(C)	(C-A)		(A)	(C)	(C-A)
Constipation	Non intervention	9	84.67 ± 16.19	82.56 ± 18.60	−2.11 ± 5.58	0.604	4.33 ± 0.78	4.04 ± 0.88	−0.30 ± 0.52	0.447	4.20 ± 0.93	3.93 ± 0.91	− 0.28 ± 0.57	0.905	3.93 ± 0.67	3.64 ± 1.03	− 0.26 ± 0.54	0.604	2.16 ± 0.98	2.67 ± 0.70	0.51 ± 0.76	0.661
Constipation	Intervention	10	91.10 ± 11.46	87.50 ± 10.87	−3.60 ± 7.43		4.67 ± 0.78	4.20 ± 0.68	−0.47 ± 0.55		4.32 ± 0.41	4.13 ± 0.31	−0.18 ± 0.40		4.00 ± 0.72	3.74 ± 0.63	− 0.26 ± 0.74		2.70 ± 0.64	3.00 ± 0.84	0.30 ± 0.65
Nausea	Non intervention	7	86.00 ± 6.95	80.57 ± 12.03	−5.43 ± 10.97	0.117	4.67 ± 0.64	4.12 ± 0.74	− 0.55 ± 0.74	1.000	4.38 ± 0.28	3.86 ± 0.75	− 0.52 ± 0.68	0.183	3.94 ± 0.54	3.49 ± 0.78	− 0.46 ± 0.67	0.017*	1.77 ± 0.41	2.37 ± 0.39	0.60 ± 0.52	0.383
Nausea	Intervention	3	88.00 ± 7.00	93.33 ± 10.26	5.33 ± 3.51		5.00 ± 0.00	4.44 ± 0.69	−0.56 ± 0.69		4.06 ± 0.92	4.17 ± 0.76	0.11 ± 0.25		3.67 ± 0.23	4.27 ± 0.12	0.60 ± 0.20		2.27 ± 0.46	3.20 ± 0.20	0.93 ± 0.31
Oral pain	Non intervention	6	82.50 ± 12.34	77.00 ± 13.78	−5.50 ± 7.04	0.776	4.44 ± 0.86	3.86 ± 0.92	−0.58 ± 0.57	0.689	4.14 ± 0.61	3.75 ± 0.74	−0.39 ± 0.75	0.529	3.80 ± 0.56	3.33 ± 0.91	− 0.50 ± 0.70	0.689	1.90 ± 0.64	2.37 ± 0.32	0.47 ± 0.74	0.529
Oral pain	Intervention	9	94.44 ± 8.63	88.44 ± 11.77	−6.00 ± 9.17		4.96 ± 0.07	4.17 ± 0.76	−0.80 ± 0.72		4.54 ± 0.59	4.09 ± 0.51	−0.44 ± 0.35		4.20 ± 0.56	3.84 ± 0.73	− 0.36 ± 0.83		2.53 ± 0.69	3.16 ± 0.49	0.62 ± 0.54
Vomiting	Non intervention	3	85.67 ± 11.02	77.67 ± 16.50	−8.00 ± 9.64	0.500	4.44 ± 0.96	4.33 ± 0.73	−0.11 ± 0.25	0.500	4.39 ± 0.35	3.44 ± 0.84	− 0.94 ± 0.67	0.500	4.13 ± 0.50	3.40 ± 1.25	− 0.73 ± 0.81	0.500	1.93 ± 0.61	2.27 ± 0.42	0.33 ± 0.58	1.000
Vomiting	Intervention	1	91.00 ± 0	96.00 ± 0	5.00 ± 0		5.00 ± 0	4.67 ± 0	− 0.33 ± 0		4.00 ± 0	4.33 ± 0	0.33 ± 0		3.80 ± 0	4.20 ± 0	0.40 ± 0		2.80 ± 0	3.40 ± 0	0.60 ± 0
Fever	Non intervention	1	85.00 ± 0	86.00 ± 0	1.00 ± 0	1.000	4.33 ± 0	3.83 ± 0	−0.50 ± 0	1.000	4.67 ± 0	4.50 ± 0	−0.17 ± 0	0.500	3.80 ± 0	3.60 ± 0	− 0.20 ± 0	1.000	1.60 ± 0	2.80 ± 0	1.20 ± 0	0.500
Fever	Intervention	3	90.67 ± 4.04	87.00 ± 17.35	−3.67 ± 13.58		4.94 ± 0.10	4.28 ± 1.25	−0.67 ± 1.15		4.78 ± 0.19	4.22 ± 0.59	− 0.56 ± 0.42		4.00 ± 0.53	3.53 ± 0.90	− 0.47 ± 0.92		1.87 ± 0.23	2.93 ± 0.31	1.07 ± 0.12
Malaise	Non intervention	12	86.75 ± 13.38	82.33 ± 14.72	−4.42 ± 7.81	0.413	4.00 ± 0.81	4.00 ± 0.81	− 0.64 ± 0.67	0.928	4.00 ± 0.75	4.00 ± 0.75	− 0.25 ± 0.56	0.487	3.60 ± 0.85	3.60 ± 0.85	− 0.28 ± 0.55	0.069	2.60 ± 0.57	2.60 ± 0.57	0.42 ± 0.73	0.786
Malaise	Intervention	11	88.36 ± 5.14	86.91 ± 9.53	−1.45 ± 7.48		4.21 ± 0.69	4.21 ± 0.69	−0.65 ± 0.65		4.08 ± 0.55	4.08 ± 0.55	−0.17 ± 0.67		3.80 ± 0.55	3.80 ± 0.55	0.11 ± 0.58		2.91 ± 0.65	2.91 ± 0.65	0.55 ± 0.97
Anorexia	Non intervention	12	86.50 ± 10.93	81.83 ± 13.33	−4.67 ± 8.37	0.582	4.67 ± 0.65	4.00 ± 0.81	− 0.67 ± 0.64	0.674	4.36 ± 0.53	3.99 ± 0.69	− 0.38 ± 0.62	0.539	3.93 ± 0.57	3.63 ± 0.85	− 0.30 ± 0.62	0.180	1.92 ± 0.68	2.48 ± 0.42	0.57 ± 0.64	0.923
Anorexia	Intervention	10	88.70 ± 5.54	86.60 ± 9.92	−2.10 ± 7.43		4.93 ± 0.16	4.35 ± 0.73	− 0.58 ± 0.67		4.33 ± 0.53	4.08 ± 0.58	− 0.25 ± 0.69		3.74 ± 0.43	3.72 ± 0.56	− 0.02 ± 0.70		2.24 ± 0.82	2.76 ± 0.56	0.52 ± 1.02
Peripheral sensory neuropathy	Non intervention	4	83.25 ± 15.74	81.25 ± 15.84	−2.00 ± 3.46	1.000	4.42 ± 0.79	3.67 ± 1.03	−0.75 ± 0.52	0.343	4.21 ± 0.88	4.21 ± 0.60	0.00 ± 0.30	0.343	3.75 ± 0.66	3.60 ± 1.02	−0.15 ± 0.62	0.686	1.95 ± 0.79	2.55 ± 0.25	0.60 ± 0.95	0.686
Peripheral sensory neuropathy	Intervention	4	86.50 ± 14.93	81.50 ± 12.66	−5.00 ± 10.39		4.38 ± 1.25	4.08 ± 1.02	− 0.29 ± 0.72		4.33 ± 0.14	4.08 ± 0.52	−0.25 ± 0.40		3.85 ± 0.76	3.40 ± 0.57	− 0.45 ± 0.85		2.35 ± 1.10	2.45 ± 0.55	0.10 ± 0.62
Alopecia	Non intervention	19	88.16 ± 13.40	85.26 ± 15.17	−2.89 ± 7.49	0.603	4.61 ± 0.66	4.21 ± 0.77	−0.40 ± 0.73	0.452	4.33 ± 0.69	4.07 ± 0.74	− 0.26 ± 0.53	0.665	3.94 ± 0.67	3.75 ± 0.87	− 0.19 ± 0.55	0.525	2.32 ± 0.91	2.68 ± 0.71	0.37 ± 0.62	0.563
Alopecia	Intervention	19	91.74 ± 9.92	88.37 ± 11.14	−3.37 ± 7.63		4.79 ± 0.58	4.22 ± 0.74	−0.57 ± 0.60		4.43 ± 0.51	4.12 ± 0.48	−0.31 ± 0.53		4.05 ± 0.66	3.92 ± 0.63	− 0.14 ± 0.67		2.50 ± 0.83	3.00 ± 0.68	0.51 ± 0.91
Nail ridging	Non intervention	11	89.36 ± 11.53	86.91 ± 14.00	−2.45 ± 7.57	0.494	4.76 ± 0.52	4.21 ± 0.68	−0.55 ± 0.69	0.392	4.33 ± 0.73	4.21 ± 0.69	−0.12 ± 0.36	0.303	3.98 ± 0.75	3.87 ± 0.86	− 0.11 ± 0.40	0.733	2.27 ± 0.79	2.66 ± 0.62	0.38 ± 0.62	0.303
Nail ridging	Intervention	13	91.92 ± 8.39	87.92 ± 10.70	−4.00 ± 8.02		4.88 ± 0.73	4.17 ± 0.65	−0.72 ± 0.63		4.45 ± 0.57	4.08 ± 0.56	−0.37 ± 0.59		4.14 ± 0.68	3.89 ± 0.66	− 0.25 ± 0.70		2.31 ± 0.83	3.08 ± 0.56	0.77 ± 0.83
Skin disorder	Non intervention	8	91.00 ± 14.69	87.50 ± 17.18	−3.50 ± 8.00	0.442	4.75 ± 0.58	4.10 ± 1.01	−0.65 ± 0.76	0.382	4.42 ± 0.67	4.13 ± 0.62	−0.29 ± 0.50	1.000	4.25 ± 0.62	4.00 ± 0.89	− 0.25 ± 0.49	0.234	2.23 ± 1.17	2.93 ± 0.76	0.70 ± 0.58	0.645
Skin disorder	Intervention	8	89.63 ± 7.19	84.88 ± 9.16	−4.75 ± 7.13		4.90 ± 0.18	4.06 ± 0.68	−0.83 ± 0.62		4.31 ± 0.57	3.94 ± 0.53	−0.38 ± 0.74		3.78 ± 0.33	3.80 ± 0.60	0.03 ± 0.59		2.43 ± 0.87	2.88 ± 0.62	0.45 ± 1.09

Mann-Whitney’s U-test, mean ± standard deviation, * P < 0.05

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