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Table 5 Comparison of the QOL-ACD total score and mean score for each subscale before 1st and 3rd course in patients with adverse events of both groups

From: Impact of pharmacist counseling on reducing instances of adverse events that can affect the quality of life of chemotherapy outpatients with breast Cancer

    Total score Subscale
Adverse event Existence of intervention n Before 1st course Before 3rd course Difference P Activity P Physical condition P Psychological condition P Social relationships P
Before 1st course Before 3rd course Difference Before 1st course Before 3rd course Difference Before 1st course Before 3rd course Difference Before 1st course Before 3rd course Difference
(A) (C) (C-A) (A) (C) (C-A) (A) (C) (C-A) (A) (C) (C-A) (A) (C) (C-A)
Constipation Non intervention 9 84.67 ± 16.19 82.56 ± 18.60 −2.11 ± 5.58 0.604 4.33 ± 0.78 4.04 ± 0.88 −0.30 ± 0.52 0.447 4.20 ± 0.93 3.93 ± 0.91 − 0.28 ± 0.57 0.905 3.93 ± 0.67 3.64 ± 1.03 − 0.26 ± 0.54 0.604 2.16 ± 0.98 2.67 ± 0.70 0.51 ± 0.76 0.661
Intervention 10 91.10 ± 11.46 87.50 ± 10.87 −3.60 ± 7.43   4.67 ± 0.78 4.20 ± 0.68 −0.47 ± 0.55   4.32 ± 0.41 4.13 ± 0.31 −0.18 ± 0.40   4.00 ± 0.72 3.74 ± 0.63 − 0.26 ± 0.74   2.70 ± 0.64 3.00 ± 0.84 0.30 ± 0.65  
Nausea Non intervention 7 86.00 ± 6.95 80.57 ± 12.03 −5.43 ± 10.97 0.117 4.67 ± 0.64 4.12 ± 0.74 − 0.55 ± 0.74 1.000 4.38 ± 0.28 3.86 ± 0.75 − 0.52 ± 0.68 0.183 3.94 ± 0.54 3.49 ± 0.78 − 0.46 ± 0.67 0.017* 1.77 ± 0.41 2.37 ± 0.39 0.60 ± 0.52 0.383
Intervention 3 88.00 ± 7.00 93.33 ± 10.26 5.33 ± 3.51   5.00 ± 0.00 4.44 ± 0.69 −0.56 ± 0.69   4.06 ± 0.92 4.17 ± 0.76 0.11 ± 0.25   3.67 ± 0.23 4.27 ± 0.12 0.60 ± 0.20   2.27 ± 0.46 3.20 ± 0.20 0.93 ± 0.31  
Oral pain Non intervention 6 82.50 ± 12.34 77.00 ± 13.78 −5.50 ± 7.04 0.776 4.44 ± 0.86 3.86 ± 0.92 −0.58 ± 0.57 0.689 4.14 ± 0.61 3.75 ± 0.74 −0.39 ± 0.75 0.529 3.80 ± 0.56 3.33 ± 0.91 − 0.50 ± 0.70 0.689 1.90 ± 0.64 2.37 ± 0.32 0.47 ± 0.74 0.529
Intervention 9 94.44 ± 8.63 88.44 ± 11.77 −6.00 ± 9.17   4.96 ± 0.07 4.17 ± 0.76 −0.80 ± 0.72   4.54 ± 0.59 4.09 ± 0.51 −0.44 ± 0.35   4.20 ± 0.56 3.84 ± 0.73 − 0.36 ± 0.83   2.53 ± 0.69 3.16 ± 0.49 0.62 ± 0.54  
Vomiting Non intervention 3 85.67 ± 11.02 77.67 ± 16.50 −8.00 ± 9.64 0.500 4.44 ± 0.96 4.33 ± 0.73 −0.11 ± 0.25 0.500 4.39 ± 0.35 3.44 ± 0.84 − 0.94 ± 0.67 0.500 4.13 ± 0.50 3.40 ± 1.25 − 0.73 ± 0.81 0.500 1.93 ± 0.61 2.27 ± 0.42 0.33 ± 0.58 1.000
Intervention 1 91.00 ± 0 96.00 ± 0 5.00 ± 0   5.00 ± 0 4.67 ± 0 − 0.33 ± 0   4.00 ± 0 4.33 ± 0 0.33 ± 0   3.80 ± 0 4.20 ± 0 0.40 ± 0   2.80 ± 0 3.40 ± 0 0.60 ± 0  
Fever Non intervention 1 85.00 ± 0 86.00 ± 0 1.00 ± 0 1.000 4.33 ± 0 3.83 ± 0 −0.50 ± 0 1.000 4.67 ± 0 4.50 ± 0 −0.17 ± 0 0.500 3.80 ± 0 3.60 ± 0 − 0.20 ± 0 1.000 1.60 ± 0 2.80 ± 0 1.20 ± 0 0.500
Intervention 3 90.67 ± 4.04 87.00 ± 17.35 −3.67 ± 13.58   4.94 ± 0.10 4.28 ± 1.25 −0.67 ± 1.15   4.78 ± 0.19 4.22 ± 0.59 − 0.56 ± 0.42   4.00 ± 0.53 3.53 ± 0.90 − 0.47 ± 0.92   1.87 ± 0.23 2.93 ± 0.31 1.07 ± 0.12  
Malaise Non intervention 12 86.75 ± 13.38 82.33 ± 14.72 −4.42 ± 7.81 0.413 4.00 ± 0.81 4.00 ± 0.81 − 0.64 ± 0.67 0.928 4.00 ± 0.75 4.00 ± 0.75 − 0.25 ± 0.56 0.487 3.60 ± 0.85 3.60 ± 0.85 − 0.28 ± 0.55 0.069 2.60 ± 0.57 2.60 ± 0.57 0.42 ± 0.73 0.786
Intervention 11 88.36 ± 5.14 86.91 ± 9.53 −1.45 ± 7.48   4.21 ± 0.69 4.21 ± 0.69 −0.65 ± 0.65   4.08 ± 0.55 4.08 ± 0.55 −0.17 ± 0.67   3.80 ± 0.55 3.80 ± 0.55 0.11 ± 0.58   2.91 ± 0.65 2.91 ± 0.65 0.55 ± 0.97  
Anorexia Non intervention 12 86.50 ± 10.93 81.83 ± 13.33 −4.67 ± 8.37 0.582 4.67 ± 0.65 4.00 ± 0.81 − 0.67 ± 0.64 0.674 4.36 ± 0.53 3.99 ± 0.69 − 0.38 ± 0.62 0.539 3.93 ± 0.57 3.63 ± 0.85 − 0.30 ± 0.62 0.180 1.92 ± 0.68 2.48 ± 0.42 0.57 ± 0.64 0.923
Intervention 10 88.70 ± 5.54 86.60 ± 9.92 −2.10 ± 7.43   4.93 ± 0.16 4.35 ± 0.73 − 0.58 ± 0.67   4.33 ± 0.53 4.08 ± 0.58 − 0.25 ± 0.69   3.74 ± 0.43 3.72 ± 0.56 − 0.02 ± 0.70   2.24 ± 0.82 2.76 ± 0.56 0.52 ± 1.02  
Peripheral sensory neuropathy Non intervention 4 83.25 ± 15.74 81.25 ± 15.84 −2.00 ± 3.46 1.000 4.42 ± 0.79 3.67 ± 1.03 −0.75 ± 0.52 0.343 4.21 ± 0.88 4.21 ± 0.60 0.00 ± 0.30 0.343 3.75 ± 0.66 3.60 ± 1.02 −0.15 ± 0.62 0.686 1.95 ± 0.79 2.55 ± 0.25 0.60 ± 0.95 0.686
Intervention 4 86.50 ± 14.93 81.50 ± 12.66 −5.00 ± 10.39   4.38 ± 1.25 4.08 ± 1.02 − 0.29 ± 0.72   4.33 ± 0.14 4.08 ± 0.52 −0.25 ± 0.40   3.85 ± 0.76 3.40 ± 0.57 − 0.45 ± 0.85   2.35 ± 1.10 2.45 ± 0.55 0.10 ± 0.62  
Alopecia Non intervention 19 88.16 ± 13.40 85.26 ± 15.17 −2.89 ± 7.49 0.603 4.61 ± 0.66 4.21 ± 0.77 −0.40 ± 0.73 0.452 4.33 ± 0.69 4.07 ± 0.74 − 0.26 ± 0.53 0.665 3.94 ± 0.67 3.75 ± 0.87 − 0.19 ± 0.55 0.525 2.32 ± 0.91 2.68 ± 0.71 0.37 ± 0.62 0.563
Intervention 19 91.74 ± 9.92 88.37 ± 11.14 −3.37 ± 7.63   4.79 ± 0.58 4.22 ± 0.74 −0.57 ± 0.60   4.43 ± 0.51 4.12 ± 0.48 −0.31 ± 0.53   4.05 ± 0.66 3.92 ± 0.63 − 0.14 ± 0.67   2.50 ± 0.83 3.00 ± 0.68 0.51 ± 0.91  
Nail ridging Non intervention 11 89.36 ± 11.53 86.91 ± 14.00 −2.45 ± 7.57 0.494 4.76 ± 0.52 4.21 ± 0.68 −0.55 ± 0.69 0.392 4.33 ± 0.73 4.21 ± 0.69 −0.12 ± 0.36 0.303 3.98 ± 0.75 3.87 ± 0.86 − 0.11 ± 0.40 0.733 2.27 ± 0.79 2.66 ± 0.62 0.38 ± 0.62 0.303
Intervention 13 91.92 ± 8.39 87.92 ± 10.70 −4.00 ± 8.02   4.88 ± 0.73 4.17 ± 0.65 −0.72 ± 0.63   4.45 ± 0.57 4.08 ± 0.56 −0.37 ± 0.59   4.14 ± 0.68 3.89 ± 0.66 − 0.25 ± 0.70   2.31 ± 0.83 3.08 ± 0.56 0.77 ± 0.83  
Skin disorder Non intervention 8 91.00 ± 14.69 87.50 ± 17.18 −3.50 ± 8.00 0.442 4.75 ± 0.58 4.10 ± 1.01 −0.65 ± 0.76 0.382 4.42 ± 0.67 4.13 ± 0.62 −0.29 ± 0.50 1.000 4.25 ± 0.62 4.00 ± 0.89 − 0.25 ± 0.49 0.234 2.23 ± 1.17 2.93 ± 0.76 0.70 ± 0.58 0.645
Intervention 8 89.63 ± 7.19 84.88 ± 9.16 −4.75 ± 7.13   4.90 ± 0.18 4.06 ± 0.68 −0.83 ± 0.62   4.31 ± 0.57 3.94 ± 0.53 −0.38 ± 0.74   3.78 ± 0.33 3.80 ± 0.60 0.03 ± 0.59   2.43 ± 0.87 2.88 ± 0.62 0.45 ± 1.09  
  1. Mann-Whitney’s U-test, mean ± standard deviation, * P < 0.05