Table 1 Effect of food intake on the pharmacokinetic parameters of OFLX after 5.3 mg/kg OFLX oral administration alone, and with 13.3 mg/kg AL in rats
From: Food intake attenuates the drug interaction between new quinolones and aluminum
Diet | AL | Cmax (μg/mL) | AUC0–6 (μg∙h/mL) | ke (h− 1) |
|---|---|---|---|---|
Fasted | – | 1.86 ± 0.26 | 2.53 ± 0.58 | 0.39 ± 0.10 |
+ | 0.32 ± 0.06* | 0.73 ± 0.11* | 0.27 ± 0.14 | |
Fed | – | 0.82 ± 0.17# | 1.82 ± 0.32# | 0.45 ± 0.09 |
+ | 0.32 ± 0.10* | 1.00 ± 0.12* | 0.32 ± 0.10 |