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Table 1 Effect of food intake on the pharmacokinetic parameters of OFLX after 5.3 mg/kg OFLX oral administration alone, and with 13.3 mg/kg AL in rats

From: Food intake attenuates the drug interaction between new quinolones and aluminum

Diet AL Cmax (μg/mL) AUC0–6 (μg∙h/mL) ke (h− 1)
Fasted 1.86 ± 0.26 2.53 ± 0.58 0.39 ± 0.10
+ 0.32 ± 0.06* 0.73 ± 0.11* 0.27 ± 0.14
Fed 0.82 ± 0.17# 1.82 ± 0.32# 0.45 ± 0.09
+ 0.32 ± 0.10* 1.00 ± 0.12* 0.32 ± 0.10
  1. Data are mean ± SD, n = 5
  2. *p < 0.05 vs respective OFLX alone group. #p < 0.05 vs fasted OFLX group