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Table 2 Univariate analysis of risk factors for oxaliplatin-induced vascular pain

From: Risk factors for oxaliplatin-induced vascular pain in patients with colorectal cancer and comparison of the efficacy of preventive methods

   Vascular pain (+) Vascular pain (−) Odds ratio 95%CI P value
  Incidence (%) n = 124 n = 66    
Gender
 Female 64.4 47 26 0.94 0.51–1.73 0.876
 Male 65.8 77 40
Age
70 62.1 41 25 0.81 0.43–1.51 0.526
  < 70 66.9 83 41
BMI
22 58.2 53 38 0.55 0.30–1.01 0.067
  < 22 71.7 71 28
Clinical stage
 IV 56.8 46 35 0.52 0.29–0.96 0.045
 I-III 71.6 78 31
History of chemotherapy
 2nd 41.2 7 10 0.34 0.12–0.93 0.035
 1st 67.6 117 56    
L-OHP dosage
  < 130 mg/m2 57.1 56 42 0.47 0.25–0.87 0.022
 130 mg/m2 73.9 68 24    
Solution volume mixed with oxaliplatin
 500 mL 67.2 41 20 1.14 0.60–2.17 0.746
 250 mL 64.3 83 46    
Warming the injection site
 Yes 63.3 81 47 0.76 0.40–1.46 0.516
 No 69.4 43 19    
Analgesics
 Yes 56.3 9 7 0.66 0.23–1.86 0.425
 No 66.1 115 59    
Opioids
 Yes 62.5 5 3 0.88 0.20–3.81 1.000
 No 65.4 119 63    
Non-opioids
 Yes 54.5 6 5 0.62 0.18–2.12 0.519
 No 65.9 118 61    
pH adjustment (addition of dexamethasone to infusion solution mixed with oxaliplatin)
 Yes 78.3 18 5 2.07 0.73–5.86 0.242
 No 63.5 106 61    
  1. CI confidence interval