Effect of coadministration of rifampicin on the pharmacokinetics of linezolid: clinical and animal studies

Table 3 mRNA expression of Mdr1a, Mrp2 and Bcrp in the small intestine with and without RFP

		mRNA expression level (copy/ng RNA)
		Control	with RFP
Mdr1a	Upper	11,800 ± 6900	14,300 ± 8300
	Middle	22,600 ± 5400	33,600 ± 11700*
	Lower	18,900 ± 7200	27,200 ± 9300
Mrp2	Upper	396 ± 164	633 ± 160*
	Middle	683 ± 231	1250 ± 542*
	Lower	299 ± 90	425 ± 131
Bcrp	Upper	3880 ± 1460	3650 ± 921
	Middle	2620 ± 252	2860 ± 526
	Lower	1250 ± 228	1170 ± 430

Values are mean ± SD of five rats. *p < 0.05
Mdr1a multidrug resistance protein 1a, Mrp2 multidrug resistance-associated protein 2, Bcrp breast cancer resistance protein

ISSN: 2055-0294