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Table 1 Patients Characteristics

From: Economic analysis of palonosetron versus granisetron in the standard triplet regimen for preventing chemotherapy-induced nausea and vomiting in patients receiving highly emetogenic chemotherapy in Japan (TRIPLE phase III trial)

 

Gra (n = 413)

Palo (n = 414)

Age, ≥60 years

290 (70.2%)

291 (70.3%)

 median (range)

64 (25–83)

63 (31–77)

Gender, male

309 (74.8%)

307 (74.2%)

ECOG Performance Status

 0

282 (68.3%)

276 (66.7%)

 1

126 (30.5%)

136 (32.9%)

 2

5 (1.2%)

2 (0.5%)

Primary tumor site

 Lung

265 (64.2%)

245 (59.2%)

 Esophageal

58 (14.0%)

56 (13.5%)

 Gastric

51 (12.4%)

65 (15.7%)

 Head and neck

23 (5.6%)

26 (6.3%)

 Other

16 (3.9%)

22 (5.3%)

CDDP dose administered (mg/m2)

  < 60

67 (16.2%)

65 (15.7%)

  ≥ 60, < 70

48 (11.6%)

57 (13.8%)

  ≥ 70, < 80

243 (58.8%)

227 (54.8%)

  ≥ 80

55 (13.3%)

65 (15.7%)

Prior chemotherapy with platinum more than 3 months earlier

21 (5.1%)

16 (3.9%)

  1. A total of 842 patients were enrolled at 20 Japanese centers between July 2011 and June 2012 and randomly assigned to either Arm PALO or GRA. 14 patients were excluded from analyses, leaving 828 patients evaluable for safety (safety population). One patient in Arm PALO had no efficacy data due to a serious adverse event soon after the antiemetic treatment. Thus, the FAS comprised 827 patients (414 in Arm PALO and 413 in Arm GRA)