From: Physical, chemical, and microbiological stability study of diluted atropine eye drops
Set concentration and storage temperature | Initial concentration at Day 0 (mg/mL) (mean ± 95% CI) | Percentage of initial Day 0 measurement (mean ± 95% CI) | |||||
---|---|---|---|---|---|---|---|
Day 14 | Day 28 | Day 60 | Day 90 | Day 120 | Day 180 | ||
0.1 mg/mL | |||||||
5 °C | 0.10 ± 0.32 | 99.00 ± 1.35 | 99.65 ± 1.21 | 98.89 ± 2.14 | 98.64 ± 1.75 | 98.45 ± 1.00 | 98.98 ± 1.19 |
25 °C | 99.98 ± 1.12 | 98.98 ± 0.41 | 99.13 ± 0.98 | 99.31 ± 0.98 | 98.78 ± 4.00 | 99.05 ± 3.71 | |
1.0 mg/mL | |||||||
5 °C | 1.00 ± 0.41 | 99.01 ± 2.55 | 99.72 ± 2.15 | 99.23 ± 0.66 | 99.18 ± 1.95 | 98.06 ± 3.45 | 99.00 ± 1.59 |
25 °C | 100.02 ± 1.38 | 99.98 ± 0.74 | 99.65 ± 3.03 | 99.11 ± 3.09 | 98.13 ± 4.10 | 98.55 ± 7.03 | |
2.5 mg/mL | |||||||
5 °C | 2.50 ± 0.01 | 99.91 ± 1.01 | 99.92 ± 1.55 | 99.84 ± 1.20 | 100.08 ± 1.88 | 98.66 ± 6.16 | 98.99 ± 0.99 |
25 °C | 100.40 ± 2.81 | 99.94 ± 2.54 | 99.75 ± 1.33 | 99.41 ± 4.44 | 99.15 ± 7.00 | 98.55 ± 5.33 | |
5.0 mg/mL | |||||||
5 °C | 5.01 ± 0.02 | 98.96 ± 6.51 | 100.10 ± 1.66 | 103.37 ± 8.90 | 101.12 ± 3.33 | 99.85 ± 6.01 | 97.87 ± 3.68 |
25 °C | 100.05 ± 1.33 | 99.88 ± 7.00 | 99.57 ± 0.81 | 100.02 ± 1.11 | 98.07 ± 7.06 | 98.97 ± 0.67 |