Table 2 Osmolality change of atropine solutions after storage (mean ± standard deviation; n = 6)
From: Physical, chemical, and microbiological stability study of diluted atropine eye drops
Set concentration and storage temperature | Initial osmolality at Day 0 (mOsm/kg) (mean ± SD) | Osmolality values (mean ± SD) | |||||
|---|---|---|---|---|---|---|---|
Day 14 | Day 28 | Day 60 | Day 90 | Day 120 | Day 180 | ||
0.1 mg/mL | |||||||
5 °C | 285 ± 0.55 | 285 ± 3.61 | 285 ± 2.70 | 285 ± 1.11 | 285 ± 1.88 | 285 ± 0.96 | 285 ± 1.34 |
25 °C | 285 ± 1.02 | 285 ± 2.13 | 285 ± 3.31 | 285 ± 1.41 | 285 ± 1.66 | 285 ± 1.14 | |
1.0 mg/mL | |||||||
5 °C | 285 ± 0.61 | 285 ± 1.50 | 285 ± 3.61 | 286 ± 3.33 | 286 ± 2.48 | 285 ± 0.82 | 286 ± 2.74 |
25 °C | 286 ± 0.22 | 285 ± 3.15 | 286 ± 3.78 | 285 ± 1.40 | 285 ± 2.35 | 286 ± 2.84 | |
2.5 mg/mL | |||||||
5 °C | 285 ± 0.54 | 285 ± 0.81 | 285 ± 2.11 | 286 ± 3.21 | 286 ± 2.66 | 285 ± 0.32 | 286 ± 3.54 |
25 °C | 284 ± 1.12 | 286 ± 1.04 | 286 ± 1.78 | 286 ± 1.41 | 286 ± 1.41 | 286 ± 1.00 | |
5.0 mg/mL | |||||||
5 °C | 285 ± 0.54 | 286 ± 1.03 | 285 ± 2.09 | 285 ± 0.99 | 285 ± 0.86 | 286 ± 1.74 | 287 ± 0.51 |
25 °C | 286 ± 1.08 | 283 ± 1.97 | 286 ± 0.87 | 286 ± 1.41 | 287 ± 4.11 | 286 ± 0.54 | |