Fig. 5

(a) The LC-MS/MS chromatograms of a plasma sample spiked with 300 ng/mL hydroxy itraconazole. The MRM transitions of (1) and (2) are 719.10/406.10 and 721.15/408.15, respectively. (b) The LC-MS/MS chromatograms of a plasma sample spiked with 20 ng/mL keto itraconazole. The MRM transitions of (1) and (2) are 721.15/408.15 and 719.10/406.10, respectively