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Table 1 Baseline characteristics of the study subjects

From: Impact of sitagliptin combination therapy and hypoglycemia in Japanese patients with type 2 diabetes: a multi-center retrospective observational cohort study

 

OHA patients (n = 2956)

non-hypoglycemia (N = 2910)

hypoglycemia (N = 46)

P-value

Sex (male%)

1772 (59.9%)

1749 (60.1%)

23 (50.0%)

0.1653

Age

65.1 ± 11.3

65.1 ± 11.3

65.9 ± 8.6

0.5311

BMIa

25.0 ± 4.3

25.1 ± 4.3

23.5 ± 3.9

0.0228

Smoking status

0.6357

 Current users

614 (23.5%)

603 (23.5%)

11 (26.8%)

 

 Past users

531 (20.3%)

525 (20.5%)

6 (14.6%)

 

 Never users

1463 (56.1%)

1439 (56.1%)

24 (58.5%)

 

 Diabetic duration

10.2 ± 7.5

10.2 ± 7.5

12.4 ± 7.2

0.0784

Comorbidity

 Coronary artery diseases

9 (0.3%)

9 (0.3%)

0 (0.0%)

0.7081

 Cerebrovascular diseases

276 (9.4%)

273 (9.4%)

3 (6.7%)

0.5295

Diabetic microvascular complications

 Retinopathy

418 (14.2%)

413 (14.3%)

5 (11.1%)

0.5493

 Neuropathy

345 (11.7%)

339 (11.7%)

6 (13.3%)

0.7350

 Nephropathy

514 (17.4%)

508 (17.5%)

6 (13.3%)

0.4619

Medication

 Number of combined OHA

1.3 ± 1.0

1.3 ± 1.0

2.1 ± 1.0

<.0001

Clinical data

 HbA1c (NGSP) (%)

7.8 ± 1.2

7.8 ± 1.2

7.9 ± 1.2

0.4905

 eGFRb

76.6 ± 22.9

76.7 ± 22.9

72.7 ± 22.6

0.2649

 HDL-C

55.6 ± 15.0

55.5 ± 15.0

56.2 ± 14.9

0.8018

 TC

193.8 ± 37.1

193.9 ± 37.2

190.4 ± 27.6

0.5306

 TG

155.0 ± 127.2

155.2 ± 127.8

140.8 ± 87.5

0.3002

 Uric acid

5.2 ± 1.6

5.2 ± 1.6

4.6 ± 1.4

0.0325

  1. BMI Body-mass index, OHAs Oral hypoglycemic agents, eGFR Estimated glomerular filtration rate, HDL-C High-density lipoprotein cholesterol, TC Total cholesterol, TG Triglyceride
  2. aThe body-mass index is body weight in kilograms divided by the square of height in meters
  3. bThe estimated GFR was calculated using the modified Modification of Diet in Renal Disease (MDRD) formula