Fig. 2
Relationship between apparent permeation clearance (CLP,app) values of the antineoplastic agents and glove thickness. The CLP,app values of the 10 antineoplastic agents through medical gloves of three different thicknesses (0.05, 0.07, and 0.1 mm) are shown. The symbols and bars indicate mean and standard deviation (SD), respectively. The symbols on the horizontal axis (indicated with an asterisk) indicate the data of antineoplastic agents that were not detected in the receptor solution throughout the permeation experiments. Statistically significant negative correlation between CLP,app and nitrile glove thickness was observed (Rs = − 0.37, P = 0.047, Spearman’s rank correlation coefficient)