Fig. 6

Schematic diagrams of behavior of antineoplastic agents in nitrile medical gloves. The behavior of antineoplastic agents during permeation through nitrile medical gloves is demonstrated. a, b and c correspond to antineoplastic agents classified in Zones A, B, and C, respectively. Since Zone A antineoplastic agents could be easily absorbed into the glove material and easily diffuse to the interface between the glove material and receptor solution, permeation rates at 240 min (PR₂₄₀ values) were expected to be high [panel (a)]. In contrast, although Zone B antineoplastic agents could be easily absorbed into the glove material, their rates of diffusion in the glove material were expected to be low due to their high molecular weights (MWs). Thus, PR₂₄₀ values were also expected to be low [panel (b)]. Zone C antineoplastic agents could not be easily absorbed into the glove material due to their low logarithm of octanol-water partition coefficient (LogP) values; thus, PR₂₄₀ values were expected to be low irrespective of their MWs [panel (c)]