Table 2 Number of neonates exposed to potentially hazardous excipients (PHEs) and prescriptions and products containing PHEs
Excipients | PMA at dose (weeks), median (range) | Weight at dose (g), median (range) | Total | Parenteral | Enteral | Topical | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of neonates (N = 343) | No. of prescriptions (N = 2360) | No. of products (N = 426) | No. of neonates (N = 225) | No. of prescriptions (N = 1475) | No. of products (N = 291) | No. of neonates (N = 200) | No. of prescriptions (N = 763) | No. of products (N = 104) | No. of neonates (N = 82) | No. of prescriptions (N = 122) | No. of products (N = 31) | |||
Aspartame | 45.4 (35.0–67.6) | 3375 (1634–3962) | 13 | 15 | 6 | 0 | 0 | 0 | 13 | 15 | 6 | 0 | 0 | 0 |
Benzalkonium chloride | 41.6 (38.6–44.6) | 2818 (263.–3006) | 3 | 6 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 6 | 2 |
Benzyl alcohol | 34.9 (23.3–71.1) | 1808 (486–6665) | 100 | 137 | 10 | 98 | 137 | 10 | 0 | 0 | 0 | 0 | 0 | 0 |
Ethanol | 36.9 (23.9–71.1) | 1820 (575–6665) | 130 | 193 | 8 | 10 | 1 | 2 | 130 | 192 | 6 | 0 | 0 | 0 |
Parabens | 38.0 (24.4–71.1) | 2062 (410–7505) | 86 | 107 | 8 | 13 | 5 | 4 | 43 | 53 | 3 | 49 | 49 | 1 |
Polysorbate 80 | 34.9 (23.3–71.1) | 1792 (487–6665) | 106 | 115 | 17 | 91 | 97 | 8 | 10 | 11 | 6 | 6 | 7 | 3 |
Propylene glycol | 36.6 (23.7–55.7) | 2116 (486–4175) | 71 | 71 | 7 | 39 | 41 | 3 | 30 | 30 | 4 | 0 | 0 | 0 |
Saccharin sodium | 35.7 (23.9–63.7) | 1768 (575–5162) | 67 | 78 | 8 | 0 | 0 | 0 | 67 | 78 | 8 | 0 | 0 | 0 |
Sodium benzoate | 36.7 (23.9–67.6) | 1768 (575–5162) | 153 | 217 | 9 | 0 | 0 | 0 | 153 | 215 | 9 | 0 | 0 | 0 |
Sorbitol | 36.9 (23.9–67.6) | 1909 (410–5162) | 161 | 170 | 6 | 23 | 30 | 3 | 140 | 140 | 3 | 0 | 0 | 0 |
At least one PHE | 36.0 (23.3–71.1) | 1808 (410–7505) | 282 | 646 | 52 | 157 | 284 | 29 | 172 | 308 | 19 | 57 | 54 | 4 |