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Table 3 The proportion that each product contributes to the total number of products containing each potentially harmful excipient

From: Potentially harmful excipients in neonatal medications: a multicenter nationwide observational study in Japan

Excipients Products name N of prescription (%) N of neonates (%)
Aspartame Carbocystein dry syrup 6 (40.0%) 6 (40.0%)
Others 9 (60.0%) 9 (60.0%)
Ethanol Soluble ferric pyrophosphate syrup 109 (56.5%) 109 (83.8%)
Alfacalcidol solution 66 (34.1%) 64 (49.2%)
Triclofos sodium oral syrup 14 (7.3%) 14 (10.8%)
Others 4 (2.1%) 4 (3.1%)
Benzalkonium chloride Atropine ophthalmic solution 2 (33.3%) 2 (66.7%)
Others 4 (66.7%) 3 (100.0%)
Benzyl alcohol Heparin sodium injections 126 (94.2%) 92 (91.1%)
Others 11 (5.8%) 10 (9.9%)
Parabens Enema solution 49 (45.8%) 49 (52.7%)
Vitamin K2 oral syrup 28 (26.2%) 28 (30.1%)
Amicacin injections 10 (9.3%) 8 (8.6%)
Triclofos sodium oral syrup 14 (13.1%) 14 (15.1%)
Others 6 (5.6%) 6 (6.5%)
Polysorbate 80 Multivitamin injections 59 (51.3%) 57 (53.8%)
Erythropoietin injections 37 (32.2%) 35 (33.0%)
Others 19 (16.5%) 17 (16.0%)
Propylene glycol Multivitamin injections 40 (56.3%) 38 (53.5%)
Vitamin K2 oral syrup 28 (39.4%) 28 (39.4%)
Others 3 (4.2%) 6 (8.5%)
Saccharin sodium Multivitamin oral powders 66 (84.6%) 63 (95.5%)
Others 12 (15.4%) 9 (13.6%)
Sodium benzoate Soluble ferric pyrophosphate syrup 109 (50.2%) 109 (71.2%)
Multivitamin oral powders 66 (30.4%) 63 (41.1%)
Vitamin K2 oral syrup 28 (12.9%) 28 (18.3%)
Others 14 (6.5%) 10 (6.5%)
Sorbitol Soluble ferric pyrophosphate syrup 109 (64.1%) 109 (67.7%)
Vitamin K2 oral syrup 28 (16.5%) 28 (17.4%)
Vitamin K2 injection 26 (15.3%) 26 (16.1%)
Others 7 (4.1%) 7 (4.3%)