Fig. 1

Reported/measured (circles) and estimated (lines) concentrations of diphenhydramine in plasma and/or tissues of healthy subjects (A) and two patients who took single oral overdoses (B,C). Plasma concentrations of diphenhydramine were measured in patients who had taken single oral overdoses of diphenhydramine of 900 mg (case 1, B) and 1200 mg (case 2, C). The modeled plasma (solid lines), hepatic (broken lines), and renal (dotted lines) concentration curves after virtual administrations of 900 and 1200 mg diphenhydramine are also shown. In panel A, reported mean plasma concentrations of diphenhydramine after an oral microdose (0.1 mg) were taken from literature [12]