Fig. 2

Experimental design for pharmacokinetic study and time course of PSP. Diamonds and circles represent PSP concentration at dose of 2.5 mg/kg and 25 mg/kg, respectively. Closed and open symbols correspond to SBECD and control groups, respectively. SBECD at 320 mg/kg (saline in control) was administered intravenously 10 min before the infusion of PSP. The dotted line represents quantitative limit of PSP (3 μM). *p < 0.05. ** p < 0.01