Table 1 Baseline characteristics of all patients

Female gender, n (%)

31

33.7%

23

24.7%

0.18

Age (yr)

70.1

14.7

64.2

17.7

0.01

Weight (kg)

56.0

11.2

61.2

12.4

 < 0.01

Comorbidities, n (%)

  Hypertension

36

39.1%

35

37.6%

0.83

  Diabetes

21

22.8%

17

18.3%

0.44

  Chronic heart failure

7

7.6%

18

19.4%

0.02

Infection site, n (%)

  Pneumonia

33

35.9%

21

22.6%

0.05

  Bacteremia

46

50.0%

30

32.3%

0.01

  Intra-abdominal

26

28.3%

20

21.5%

0.29

  SOFA score (median/quartile)

8

(11–14)

4

(6–8)

 < 0.01

Organ support, n (%)

  Invasive mechanical ventilation

68

73.9%

55

59.1%

0.03

  Renal replacement therapy

52

56.5%

28

30.1%

 < 0.01

  Vasopressors

65

70.7%

18

19.4%

 < 0.01

Drugs, n (%)

  Diuretics

6

6.5%

18

19.4%

 < 0.01

  Nicardipine

5

5.4%

10

10.7%

0.19

  Plasma creatinine (mg/dL)

1.95

1.44

1.64

1.82

0.21

Vital sign at IVIG/acetaminophen infusion

  SBP (mmHg)

109.0

27.0

128.8

28.2

 < 0.01

  MAP (mmHg)

74.6

18.4

82.6

17.0

 < 0.01

  DBP (mmHg)

55.6

15.1

59.6

14.1

0.06

  HR (beats/min)

101.1

20.8

101.9

22.2

0.79