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Table 2 Costs of drugs and rescue treatment

From: Cost-effectiveness analysis of olanzapine in four-drug antiemetic therapy in Japanese patients treated with highly emetogenic cisplatin-containing chemotherapy

Study drug costs

Cost (JPY)

(Range for one-way sensitivity analysis)

Distribution type for PSA

Reference

Olanzapine 5.0 mg (oral)

150.4 (28.9 ~ 150.4)

Did not vary

NHI price list

Aprepitant 125 mg (oral)

1659.4

Did not vary

NHI price list

Aprepitant 80 mg (oral)

1125.0

Did not vary

NHI price list

Palonosetron 0.75 mg (intravenous)

5349.0

Did not vary

NHI price list

Dexamethasone 4.0 mg (oral)

29.9

Did not vary

NHI price list

Non-olanzapine regimen

(APR + PALO + DEX)

9527.5

Did not vary

NHI price list

Olanzapine regimen

(OLA + APR + PALO + DEX)

10,129.1 (9643.1 ~ 10,129.1)

Did not vary

NHI price list

Rescue treatments

(IC for acute phase)

833.8 (167.1 ~ 1500.5)

Normal

(Mean = 833.8, SE = 340.1)

[24]

Rescue treatments

(CC for acute phase, IC for delayed phase)

286.5 (97.3 ~ 475.7)

Normal

(Mean = 286.5, SE = 96.5)

[24]

  1. Non-olanzapine regimen comprised 12 mg Dexamethasone on Day 1 and 8 mg on Days 2–4, 0.75 mg palonosetron on Day 1, 125 mg aprepitant on Day 1 and 80 mg on Days 2 and 3
  2. APR aprepitant, CC complete control, CI confidence interval, DEX dexamethasone, IC incomplete control, JPY Japanese Yen, NHI National Health Insurance, OLA olanzapine, PALO palonosetron, PSA probabilistic sensitivity analysis