Fig. 2

Representative chromatograms for linezolid in plasma and linezolid in synovial fluid. Plasma (A) and synovial fluid (B) samples from case 1 before (thin lines) and after (thick lines) treatment with linezolid twice a day were investigated. Possible linezolid 2-hydoxylated metabolite(s) mediated by recombinant human P450 2 J2 in an in vitro system (dashed lines) was used for chromatographic comparison. The retention times of linezolid and its possible 2-hydroxylated metabolite [9] were 7.4 and 5.9 min respectively