Table 1 Patients’ characteristics

Age (years)

71 [51–84]

71 [48–84]

0.744

Male

37 (84)

54 (82)

0.803

Body weight (kg)

52.7 [33.0–80.0]

53.1 [32.2–79.2]

0.502

CDDP dose (mg)

110 [75–140]

113 [71–140]

0.424

5-FU dose (mg)

1110 [918–1400]

1137 [770–1400]

0.357

Infusion volume (L)

2.0 [1.4–5.0]

2.7 [1.5–3.7]

0.544

Urine volume (L)

5.6 [3.1–10.7]

5.6 [3.7–9.6]

0.145

 AST (U/L)

20 [9–57]

21 [13–50]

0.501

 ALT (U/L)

14 [6–68]

17 [6–64]

0.081

 Scr (mg/dL)

0.84 [0.43–1.15]

0.78 [0.44–1.25]

0.408

 BUN (mg/dL)

14 [7–22]

16 [6–22]

0.505

 WBC (×10⁹/L)

5.37 [3.48–8.83]

5.33 [2.68–9.29]

0.998

 PLT (×10⁹/L)

234 [127–609]

217 [103–398]

0.101

 ANC (×10⁹/L)

3.17 [1.86–6.72]

3.31 [1.65–6.96]

0.674

 Hb (g/dL)

12.8 [9.4–16.2]

12.9 [9.2–16.2]

0.807

 Diabetes mellitus

6 (14)

6 (9)

0.538

 Cardiovascular disease

2 (5)

5 (8)

0.700

 Diuretics

6 (14)

7 (11)

0.765

 NSAIDs

11 (25)

23 (35)

0.300

 PPIs

22 (50)

41 (62)

0.241

 Magnesium oxide

15 (34)

27 (41)

0.550