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Table 5 Baseline Patient’s Characteristics Stratified by All-cause mortality at 30 days

From: Prognostic factors in patients with septic disseminated intravascular coagulation treated with thrombomodulin: the effect of reduced thrombomodulin dose; a single-center, retrospective, observational study

 

All-cause mortality at 30 days

Yes (N = 30)

No (N = 72)

p value

Patient characteristics

 Age, years

74 (69–80)

77 (67–84)

0.683a

 Male sex

21 (70.0)

37 (51.4)

0.124c

 Body mass index

21.4 (17.0–24.2)

21.7 (19.2–25.5)

0.352a

 Creatinine clearance, mL/min

21.3 (12.7–29.4)

20.6 (12.4–42.6)

0.523a

 Renal replacement therapy

20 (66.7)

35 (48.6)

0.147b

 Malignancy

8 (26.7)

14 (19.4)

0.437c

 Serum albumin, mg/dL

2.15 (1.90–2.50)

2.45 (2.08–2.73)

0.093a

Illness severity

 SOFA score

15 (12–17)

10 (8–12)

< 0.001a

 JAAM-DIC score

6 (5–7)

6 (5–7)

0.448a

 SIRS criteria

3 (2–4)

3 (2–4)

0.832a

Primary type of Infection

 Intra-abdominal infection

4 (13.3)

21 (29.2)

0.129c

 Pneumonia

14 (46.7)

9 (12.5)

< 0.001c

 Urinary tract infection

2 (6.7)

15 (20.8)

0.142c

 Cholangitis/Cholecystitis

0 (0.0)

9 (12.5)

0.055c

 Blood stream infection

3 (10.0)

4 (5.6)

0.417c

 Infectious enteritis

0 (0.0)

2 (2.8)

1.000c

 Necrotizing fasciitis/Gas gangrene

0 (0.0)

2 (2.8)

1.000c

 Osteomyelitis

1 (3.3)

1 (1.4)

0.504c

 Iliopsoas muscle abscess/Retroperitoneal abscess

0 (0.0)

2 (2.8)

1.000c

 Unknown

5 (16.7)

4 (5.6)

0.119c

Treatment

 Dose reduction of TM

14 (46.7)

16 (22.2)

0.026b

 Antithrombin III

26 (86.7)

52 (72.2)

0.133c

 Heparin

1 (3.3)

2 (2.8)

1.000c

 Fresh frozen plasma

11 (36.7)

18 (25.0)

0.342b

 Platelet Concentrate

12 (40.0)

25 (34.7)

0.780b

 PMX-DHP

8 (26.7)

40 (55.6)

0.009c

  1. Data are presented as median (interquartile range) or number (%)
  2. SOFA Sequential organ failure assessment, JAAM-DIC Japanese Association for Acute Medicine DIC diagnostic criteria, DIC disseminated intravascular coagulation, SIRS Systemic inflammatory response syndrome, PMX-DHP Polymyxin B immobilized fiber column direct hemoperfusion
  3. aMann-Whitney U test
  4. bChi-square test
  5. cFisher’s exact test