Fig. 3

Schematic diagram of the final population pharmacokinetic model. Transit compartments (a₁-a₆), absorption compartment, central compartment, and peripheral compartment for MPA. Ktr, rate constant of transit compartment [Ktr = (n + 1) / MTT, where n is the estimated number of transit compartments prior to the absorption compartment and MTT is the mean transit time into the first depot compartment]; Ka, absorption rate constant; V₁, central compartment volume of distribution; V₂, peripheral compartment volume of distribution; CL, central compartment clearance; Q, inter-compartmental clearance