PIBP incidence | Univariate analysis | Multivariate analysis | |||||
---|---|---|---|---|---|---|---|
N (%) | OR | 95% CI | p-value* | OR | 95% CI | p-value* | |
Sex | |||||||
Male | 2 (3) | Reference | Reference | ||||
Female | 28 (12) | 5.54 | 1.29–23.83 | 0.021 | 1.909 | 0.35–10.16 | 0.455 |
Age | |||||||
< 55 years | 21 (20) | 5.31 | 2.32–12.07 | > 0.001 | 3.62 | 1.51–8.69 | 0.004 |
≥ 55 years | 9 (5) | Reference | Reference | ||||
Pre-existing osteoporosis | |||||||
Yes | 0 | NA | - | ||||
No | 30 (10) | NA | - | ||||
Type of tumor | |||||||
Solid cancers | 27 (14) | 5.39 | 1.60–18.21 | 0.007 | 2.52 | 0.62–10.19 | 0.194 |
Hematologic cancers | 3 (3) | Reference | Reference | ||||
Bone metastasis | |||||||
Present | 3 (10) | 0.71 | 0.21–4.84 | 0.596 | - | ||
Absent | 27 (10) | Reference | - | ||||
Opioids | |||||||
Yes | 1 (8) | 0.79 | 0.09–6.02 | 0.784 | - | ||
No | 29 (10) | Reference | - | ||||
NSAIDs | |||||||
Yes | 2 (13) | 1.33 | 0.28–6.16 | 0.714 | - | ||
No | 28 (10) | Reference | - | ||||
Prior chemotherapy | |||||||
Yes | 4 (14) | 1.61 | 0.52–4.99 | 0.412 | - | ||
No | 26 (9) | Reference | - | ||||
Type of chemotherapy | |||||||
Adjuvant chemotherapy | 21 (14) | 2.93 | 1.29–6.62 | 0.010 | - | ||
Chemotherapy alone | 9 (6) | Reference | - | ||||
Type of prophylaxis | |||||||
Primary | 23 (9) | 1.48 | 0.60–3.64 | 0.410 | |||
Secondary | 7 (13) | Reference | |||||
Pegfilgrastim injection | |||||||
Days 2 or 3 | 10 (8) | Reference | - | ||||
Days 4–7 | 20 (11) | 1.53 | 0.69–3.38 | 0.298 | - |