Table 1 Classification of Adverse Drug Reactions Probability for Deferoxamine and Colistin Assessed by the Naranjo Probability Scale [9]
Number | Questions | Outcome of DFO and colistin | DFO Score | Colistin score |
|---|---|---|---|---|
1 | Are there previous conclusive reports of this reaction? | AKI is described in package insert of DFO. Colistin induced AKI is most prominent. | +1 | +1 |
2 | Did ADR appear after the drug was given? | AKI developed after administration of DFO and colistin, respectively | +2 | +2 |
3 | Did ADR improve when the drug was discontinued or a specific antagonist was given? | AKI was ameliorated after discontinuation of DFO. S-Cre was continuously increased despite cessation of colistin. | +1 | 0 |
4 | Did ADR reappear upon re-administering the drug? | Neither drug was re-administrated. | 0 | 0 |
5 | Were there other possible causes for the reaction? | Due to absence of clinical conditions, AKI caused by DFO or colistin was considered. | -1 | -1 |
6 | Did ADR reappear upon administration of placebo? | Not done for either | 0 | 0 |
7 | Was the drug detected in the blood or other fluids in toxic concentrations? | Not analyzed in either | 0 | 0 |
8 | Was the reaction worsened/lessened upon increasing/decreasing the dose? | Not applied, due to no dose adjustment for either | 0 | 0 |
9 | Did the patient have a similar ADR to the drug or a related agent in the past? | No previous exposure for either | 0 | 0 |
10 | Was ADR confirmed by any other objective evidence? | Not done for either | 0 | 0 |
Total score | 3 | 2 |