Fig. 2

Viscosity (A), solubility (B), and drug release (C-E) of FEL-MP and FEL-NP gels. The solubility of FEL micro- and nanoparticles in FEL dispersions and gels was measured (B). A Franz diffusion cell was used to measure the release of FEL particles from the gel (C), and the particle size distribution of FEL released from the gel was measured using NANOSIGHT LM10 (E). n = 8. ^* P < 0.05, vs. FEL-MP gel for each category. Moreover, 92.1% FEL was present as solid particles, and FEL nanoparticles were released from the gel. The FEL concentration after release from FEL-NP gel was significantly higher than that from FEL-MP gel