Fig. 1

Summary of blood glucose transition and treatment course. The x-axis indicates the number of days and day 0 indicates the day of the initiation of vadadustat. The y-axis indicates fasting blood glucose before breakfast (a), before lunch (b), and before dinner (c). Closed circles show the self-monitoring of blood glucose. Solid lines indicate a blood glucose level of 70 mg/dL, defined as hypoglycemia. On day 23, the patient developed hypoglycemia with a blood glucose level of 67 mg/dL before breakfast. Black, gray, light gray, and white bars represent the period before vadadustat (days -14 to -1), concomitant with vadadustat (days 0 to 23), discontinuation of vadadustat (days 24 to 37), and concomitant with daprodustat (days 57 to 70). Hatched bar represents the period between vadadustat discontinuation and daprodustat initiation (days 38 to 56). Each value represents the blood glucose mean (± standard deviation) during indicated periods. Bars below the graphs represent the administration of hypoglycemic drugs (insulin glargine, mitiglinide, voglibose, sitagliptin, and linagliptin) and HIF-PHD inhibitors (vadadustat and daprodustat)