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  1. Dexamethasone (DEX) induces CYP3A activity in a concentration-dependent manner. However, no study has examined changes in the blood concentration of CYP3A substrate drugs when DEX is administered at high doses...

    Authors: Yoshiyuki Ohno, Toyohito Oriyama, Akira Honda, Mineo Kurokawa and Tappei Takada
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:39
    Content type: Case report Published on:

  2. Several methods have been reported for detecting resistance genes or phenotypic testing on the day of positive blood culture in Escherichia coli or Klebsiella pneumoniae bacteremia. However, some facilities have ...

    Authors: Mikiyasu Sakai, Takamasa Sakai, Yuki Nagata, Hiroko Komai, Yoshio Miyake, Toshitaka Watariguchi, Atsushi Kawabata and Fumiko Ohtsu
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:43
    Content type: Research article Published on:

  3. Suvorexant and ramelteon have been presented as useful for preventing postoperative delirium. Previous studies reported on the comparison with benzodiazepine hypnotics which have been known for the risk for in...

    Authors: Shoya Ikeuchi, Rei Tanaka, Teiichi Sugiura, Kaori Shinsato, Akane Wakabayashi, Junya Sato, Keiko Suzuki and Michihiro Shino
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:42
    Content type: Research article Published on:

  4. Gastrointestinal injuries caused by nonsteroidal anti-inflammatory drugs (NSAIDs) is a serious side effect in patients with rheumatoid arthritis (RA). However, effective therapeutic strategies have yet to be e...

    Authors: Saori Deguchi, Ayusa Iwakami, Mizuki Tujigiwa, Hiroko Otake, Yu Mano, Naoki Yamamoto, Yosuke Nakazawa, Manju Misra and Noriaki Nagai
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:44
    Content type: Research article Published on:

  5. Drug therapy is a crucial aspect of heart failure management and has been shown to reduce morbidity and mortality in heart failure patients. However, the comparative effects of these drug classes on readmissio...

    Authors: Birhanu Ayenew, Prem Kumar, Adem Hussein, Yegoraw Gashaw, Mitaw Girma, Abdulmelik Ayalew and Beza Tadesse
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:49
    Content type: Research article Published on:

  6. Tedizolid is an oxazolidinone anti-MRSA drug with included in the National Health Insurance Drug Price List in 2018. The effect of hemodialysis on tedizolid phosphate concentrations has been reported; pre-dial...

    Authors: Satoshi Yoshikawa, Shinichi Yoshikawa, Akira Sato and Tsukasa Matsumoto
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:37
    Content type: Research article Published on:

  7. The loading dose of teicoplanin (TEIC) is recommended for implementation. However, there is significant discrepancy between the dose settings in the package insert and, in the guidelines, and the actual status...

    Authors: Ryota Goto, Yuichi Muraki, Ryo Inose, Moeno Ichii, Keisuke Sawada, Kanako Mizuno, Ryuji Koizumi, Shinya Tsuzuki, Masahiro Ishikane and Norio Ohmagari
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:35
    Content type: Research article Published on:

  8. We previously demonstrated that in a Japanese national university’s medical faculty, overall paper publication frequency increased between 1979–1980 and 2017–2018, while original paper publication did not inc...

    Authors: Theron Muller, Miho Takano and Nicole Gallagher
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:34
    Content type: Short report Published on:

  9. Tedizolid is a new oxazolidinone antibiotic with high potency for the treatment of infections caused by methicillin-resistant Staphylococcus aureus and other species.

    Authors: Daisuke Negishi, Okimichi Mitsumatsu, Hiromi Mitsumatsu, Miaki Makiguchi, Makiko Shimizu and Hiroshi Yamazaki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:33
    Content type: Case report Published on:

  10. Among Japanese pharmacists, there is a gap in their commitment to self-improvement and a possible gap in their ability to identify and solve problems. However, the factors causing this situation have not yet b...

    Authors: Keigo Watanabe, Takamasa Sakai and Fumiko Ohtsu
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:31
    Content type: Research article Published on:

  11. In-hospital therapeutic drug monitoring (TDM) requires a suitable quantification method for target drugs from the viewpoint of precision, throughput, and testing costs. We previously developed a practical HPLC...

    Authors: Go Morikawa, Kazuto Fukami, Yukiko Moriiwa, Katsuko Okazawa and Akio Yanagida
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:29
    Content type: Research article Published on:

  12. We conducted a systematic review and meta-analysis to summarize the available literature and comprehensively appraise the renal profiles of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in Japanese patien...

    Authors: Junichi Mukai, Nakaba Okamura, Yuki Saito and Rie Kubota
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:36
    Content type: Research article Published on:

  13. Optimised antithrombotic therapy requires clinical experience and an understanding of the current guidelines. This retrospective study aimed to evaluate whether pharmacist interviews and interventions with pat...

    Authors: Tomoko Kurimura, Kazuhiro Yamamoto, Hidekazu Tanaka, Takayoshi Toba, Takeshi Kimura, Yasushi Habu, Kotaro Itohara, Yumi Kitahiro, Tomohiro Omura and Ikuko Yano
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:28
    Content type: Research article Published on:

  14. Enteral nutritional supplements are used in many medical facilities and home care, but require appropriate management because they are nutrient-rich products. Recently, infection control methods for Ready To H...

    Authors: Sachiko Omotani, Kanaha Murakami, Arisa Naka, Yasutoshi Hatsuda and Michiaki Myotoku
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:27
    Content type: Research article Published on:

  15. Epilepsy is a common neurological disorder. Lacosamide is a third-generation antiepileptic drug used to treat partial-onset seizures. Limited information is currently available on the transfer of lacosamide to...

    Authors: Ayako Furugen, Ayako Nishimura, Takeshi Umazume, Hina Ishikawa, Katsuya Narumi and Masaki Kobayashi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:26
    Content type: Research article Published on:

  16. Difficulty in taking solid medicines is a common issue particularly for the elderly because of a decline in swallowing function, also known as dysphagia. For patients with such a dysfunction, a simple suspensi...

    Authors: Ginjiro Kato, Hidemichi Mitome, Yusura Miyauchi, Syu Takeda, Yoshito Toyota, Noriaki Hidaka, Mamoru Tanaka and Kazuki Akira
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:32
    Content type: Research article Published on:

  17. Promoting stem cell donation behaviors could be crucial in advancing stem cell-based treatment, research and improving public health in Saudi Arabia. Donation of stem cells can be considered an act of social w...

    Authors: Asma Ayyed AL-Shammary and Sehar un-Nisa Hassan
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:30
    Content type: Research article Published on:

  18. Combination therapy with tazobactam/ceftolozane (TAZ/CTLZ) and high-dose aminoglycosides has been reported to be efficacious in extensively drug-resistant (XDR)-Pseudomonas aeruginosa infection. However, there ar...

    Authors: Yuta Ibe, Ryuichiro Kakizaki, Hirotoshi Inamura, Tomoyuki Ishigo, Yoshihiro Fujiya, Hiroyuki Inoue, Shuji Uemura, Satoshi Fujii, Satoshi Takahashi, Eichi Narimatsu and Masahide Fukudo
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:25
    Content type: Case report Published on:

  19. Olanzapine treatment prevents chemotherapy-induced nausea and vomiting (CINV) in patients receiving highly emetogenic chemotherapy (HEC). However, its role in the secondary prevention of breakthrough CINV in r...

    Authors: Akihiro Uchiike, Haruka Kono, Katsuhiro Miura, Tatsuya Hayama, Daisuke Tsutsumi, Shinya Tsuboi, Susumu Ohtsuka and Shinji Hidaka
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:24
    Content type: Research article Published on:

  20. In Japan, the use of risperidone in combination with adrenaline is contraindicated, except in cases of anaphylaxis. Therefore, there is limited clinical evidence regarding the interaction of these two drugs. H...

    Authors: Takafumi Nakano, Yoshihiko Nakamura, Keisuke Sato, Yoshito Izutani, Hiroto Iyota, Misaki Aoyagi, Taisuke Kitamura, Toshinobu Hayashi, Koichi Matsuo, Kenichi Mishima, Hidetoshi Kamimura, Hiroyasu Ishikura and Takashi Egawa
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:23
    Content type: Case report Published on:

  21. While cancer is a risk factor for developing thromboembolism, so is the use of molecularly targeted therapies. This study aimed to determine whether thromboembolism incidence differed between vascular endothel...

    Authors: Ryo Takada, Miki Fujiwara, Masatoshi Maki, Yoko Takahashi and Koji Tamura
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:22
    Content type: Short report Published on:

  22. The immersing powdered crude drugs (IPCD) method is a quick and simple method for preparing decoctions. Here, the conventional and IPCD methods were compared for the color and extraction of quantitative indica...

    Authors: Kazumasa Naruhashi, Natsumi Amaike, Karen Shiraishi, Sumire Sato, Chiho Uryuzu, Yui Saito and Narumi Tsue
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:21
    Content type: Research article Published on:

  23. It is important to design an effective formulation to enhance the skin penetration, and nanotechnologies have been used in dermal and transdermal drug delivery. In this study, we prepared formulations (gels) c...

    Authors: Reita Kadowaki, Fumihiko Ogata, Aoi Fushiki, Saki Daimyo, Saori Deguchi, Hiroko Otake, Mayumi Nagata, Hiroshi Sasaki, Naohito Kawasaki and Noriaki Nagai
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:20
    Content type: Research article Published on:

  24. Insulin treatment is widely used not only for type 1 but also for type 2 diabetes patients. Insulin must be injected into the subcutaneous tissue to be effective. The needle length has been shortened for safet...

    Authors: Aya Torii-Goto, Kana Hirai, Yuri Inukai, Yoshimi Hoshina, Kazumi Shiomi, Junko Ito and Masae Yoshikawa
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:19
    Content type: Research article Published on:

  25. Erythrocyte transfusion is an indispensable component of supportive care after hematopoietic stem cell transplantation (HSCT). However, HSCT recipients are susceptible to the development of acute kidney injury...

    Authors: Hirokazu Nakayama, Yoshimasa Kamoda, Michiya Tanuma, Toshiaki Kato and Kensuke Usuki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:18
    Content type: Case report Published on:

  27. High-flow continuous hemodiafiltration (HF-CHDF) combines diffusive and convective solute removal and is employed for artificial liver adjuvant therapy. However, there is no report on dosage planning of vancom...

    Authors: Yuriko Ito, Junya Nakade, Akihiro Seki, Ryosuke Gabata, Mitsuyoshi Okazaki, Shinichi Nakanuma, Arimi Fujita, Tsutomu Shimada, Taro Yamashita, Shintaro Yagi, Takumi Taniguchi and Yoshimichi Sai
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:15
    Content type: Case report Published on:

  28. Alectinib, crizotinib, and ceritinib, are anaplastic lymphoma kinase-tyrosine kinase inhibitors (ALK-TKIs) that exhibit high protein binding, and their metabolism is associated with the cytochrome P450 (CYP) i...

    Authors: Takashi Kato, Yusuke Kunimoto, Manabu Kitagawa, Yuichiro Asai, Tomoko Kimyo, Hiromasa Nakata, Mamoru Takahashi, Hirofumi Chiba, Hiroki Takahashi, Atsushi Miyamoto and Masahide Fukudo
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:14
    Content type: Case report Published on:

  29. Authors: Shinya Tsuboi, Tatsuya Hayama, Katsuhiro Miura, Akihiro Uchiike, Daisuke Tsutsumi, Takashi Yamauchi, Yoshihiro Hatta and Susumu Ootsuka
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:16
    Content type: Correction Published on:

    The original article was published in Journal of Pharmaceutical Health Care and Sciences 2023 9:2

  30. Rhabdomyolysis is a potentially life-threatening disease caused by melting or necrosis of skeletal muscle cells and leakage of muscle components into the bloodstream. It has been reported that the interaction ...

    Authors: Keiki Sakurama, Yuki Iguchi, Sara Haruki, Yusuke Hata, Madoka Hiraga, Shinya Yumoto and Yutaka Kai
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:13
    Content type: Case report Published on:

    The Correction to this article has been published in Journal of Pharmaceutical Health Care and Sciences 2023 9:17

  31. Drug-drug interaction management is complex. Nirmatrelvir/ritonavir is a potent cytochrome P450 (CYP) 3A inhibitor and influences pharmacokinetics of co-administered drugs. Although there are several reports a...

    Authors: Ayumi Tsuzawa, Yoshiki Katada, Keisuke Umemura, Mitsuhiro Sugimoto, Asami Nishikawa, Yu-ki Sato, Yuko Yoshida, Noriaki Kitada, Atsushi Yonezawa, Daisuke Nakajima, Hiroshi Date and Tomohiro Terada
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:12
    Content type: Case report Published on:

  32. Fluconazole (FLCZ) inhibits cytochrome P450 (CYP) 2C9, 2C19, and 3A4 and has a drug-drug interaction that potentiates the effects of warfarin and prolong the prothrombin time-international normalized ratio (PT...

    Authors: Hayato Akamatsu, Hiroo Nakagawa, Ichiro Matsumaru, Junya Hashizume, Hitomi Harasawa, Yukinobu Kodama, Takashi Miura and Kaname Ohyama
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:11
    Content type: Case report Published on:

  33. Polypharmacy, defined as the concurrent use of over six drugs, is common in the treatment of heart failure (HF); however, unpredictable drug interactions with bepridil may occur. In this study, we have elucida...

    Authors: Yuki Asai, Hiroki Arihara, Saki Omote, Ena Tanio, Saena Yamashita, Takashi Higuchi, Ei Hashimoto, Momoko Yamada, Hinako Tsuji, Yoshihiro Kondo, Makoto Hayashi and Yoshiaki Yamamoto
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:10
    Content type: Research article Published on:

  34. Supporting people living with HIV using anti-retroviral therapy (ART) is important due to the requirement for strict medication adherence. To date, no data from longitudinal studies evaluating adherence by tre...

    Authors: Yusuke Sekine, Takashi Kawaguchi, Yusuke Kunimoto, Junichi Masuda, Ayako Numata, Atsushi Hirano, Hiroki Yagura, Masashi Ishihara, Shinichi Hikasa, Mariko Tsukiji, Tempei Miyaji, Takuhiro Yamaguchi, Ei Kinai and Kagehiro Amano
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:9
    Content type: Research article Published on:

  35. There is no unified view of the necessity of prophylactic antimicrobial agents in trabeculectomy. Preoperative prophylactic antimicrobial agent injection and cefazolin sodium (CEZ) for trabeculectomy were disc...

    Authors: Yuuka Ushio, Hiroshi Yoshikawa, Tetsuya Murase, Tatsuo Kataoka, Shohei Miyamoto, Kazunari Maruko, Shoko Okamoto, Yuuka Shibata, Ryotaro Toda, Yoshiaki Kiuchi and Hiroaki Matsuo
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:8
    Content type: Short report Published on:

  36. Cancer-related fatigue (CRF) is one of the most common symptoms in patients with cancer. However, CRF has not been sufficiently evaluated as it involves various factors. In this study, we evaluated fatigue in ...

    Authors: Takuya Fujihara, Motohiko Sano, Yutaka Negoro, Shinji Yamashita, Hideya Kokubun and Ryoichi Yano
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:7
    Content type: Research article Published on:

  37. One-dose packaging is frequently used in Japan for elderly patients who are prescribed several medications. It is useful for easy administration and the prevention of misuse or missed medications. Hygroscopic ...

    Authors: Taisuke Matsuo, Takayuki Yoshida, Kiyotaka Ushijima, Takashi Doi, Yasuyuki Sadzuka and Takashi Tomita
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:6
    Content type: Research article Published on:

  38. We aimed to evaluate the factors associated with baloxavir prescription in Japanese hospitals using a health insurance claim-based database (MDV analyzer), during the 2018/2019 and 2019/2020 influenza seasons....

    Authors: Naomi Fujiwara, Takashi Fujiwara and Yuya Ise
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:3
    Content type: Short report Published on:

  39. For pharmacists expected to encounter the deaths of many of their patients in the near future, it is important to understand the perception of a “good death” for patients with cancer who are likely to be aware...

    Authors: Reiko Konishi, Junichi Isogai, Akira Mukai, Koji Komori, Takashi Majima, Shinji Ito and Kou Kawada
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:5
    Content type: Research article Published on:

  40. Dasatinib, which is used to treat treating chronic myeloid leukemia, induces increases in blood lymphocytes during the treatment. In addition, neutrophil–lymphocyte count ratio (NLR) is associated with the rel...

    Authors: Hirokazu Nakayama, Hiromitsu Iizuka, Toshiaki Kato and Kensuke Usuki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:4
    Content type: Short report Published on:

  41. Pegfilgrastim is widely used for the prevention of febrile neutropenia (FN) in patients receiving myelosuppressive chemotherapy for various types of cancer. However, pegfilgrastim-induced bone pain (PIBP) is a...

    Authors: Shinya Tsuboi, Tatsuya Hayama, Katsuhiro Miura, Akihiro Uchiike, Daisuke Tsutsumi, Takashi Yamauchi, Yoshihiro Hatta and Susumu Ootsuka
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:2
    Content type: Short report Published on:

    The Correction to this article has been published in Journal of Pharmaceutical Health Care and Sciences 2023 9:16

  42. Mycophenolate mofetil (MMF), a prodrug of the immunosuppressive agent mycophenolic acid (MPA), is difficult to administer because of the pharmacokinetic complexity of MPA. Although dosage adjustment according ...

    Authors: Tomoko Mizaki, Hironobu Nobata, Shogo Banno, Makoto Yamaguchi, Hiroshi Kinashi, Shiho Iwagaitsu, Takuji Ishimoto, Yukiko Kuru, Masafumi Ohnishi, Ken-ichi Sako and Yasuhiko Ito
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:1
    Content type: Research Article Published on:

  43. Long-term use of proton pump inhibitors (PPIs) has been found to significantly lower serum magnesium levels in patients in the USA and Europe. The package inserts of PPIs in these countries clearly state that ...

    Authors: Nobuhiko Nakamura, Kanaha Yoneda, Takashi Higo and Masaaki Kusumoto
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:35
    Content type: Research article Published on:

  44. The number of medications, number of administrations per day, dosing frequency on indicated day, and medication from multiple prescriptions are the medication factors prone to medication errors in self-managem...

    Authors: Ryohei Suzuki, Takako Uchiya, Takamasa Sakai, Masaaki Takahashi and Fumiko Ohtsu
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:37
    Content type: Research article Published on:

  45. Human soluble recombinant thrombomodulin (TM alfa), a treatment for septic Disseminated intravascular coagulation (DIC), is recommended for patients with severe renal dysfunction in reduced doses. However, no ...

    Authors: Yoshihiro Nishita, Masatoshi Taga, Masaru Sakurai, Yoshitsugu Iinuma and Togen Masauji
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:32
    Content type: Research article Published on:

  46. Inappropriate medication prescribing and dispensing by physicians and pharmacists is a preventable cause of morbidity and mortality in the elderly. Signifying the importance of healthcare professionals’ knowle...

    Authors: Wuraola Akande-Sholabi and Adeola Fafemi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:36
    Content type: Research article Published on:

  47. Allopurinol is used to treat hyperuricemia and gout. It is metabolized to oxypurinol by xanthine oxidase (XO), and aldehyde oxidase (AO). Allopurinol and oxypurinol are potent XO inhibitors that reduce the pla...

    Authors: Yoshitaka Tayama, Kazumi Sugihara, Seigo Sanoh, Katsushi Miyake, Shigeyuki Kitamura and Shigeru Ohta
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:31
    Content type: Research article Published on:

  48. During the coronavirus disease (COVID-19) pandemic, general strategies for preventing infectious diseases, such as social distancing and the use of protective equipment have resulted in communication barriers ...

    Authors: Masaki Maehara and Masayasu Sugiyama
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:34
    Content type: Research article Published on:

  49. Immunotherapy with immune checkpoint inhibitors is associated with immune-related adverse events (irAEs). A positive correlation between treatment efficacy and irAEs has been reported. Clinical indicators are ...

    Authors: Maiko Machida, Chika Yamazaki, Nao Kouda, Yousei Hanai, Hideki Sato, Ainari Konda, Yuka Yamagata, Tatsuya Itho and Haruhiko Aisaka
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:29
    Content type: Case report Published on:

  50. Gefitinib and erlotinib, are epidermal growth factor receptor tyrosine kinase inhibitors, and are currently recommended for non-small cell lung cancer stage IV in the elderly and in patients with decreased per...

    Authors: Hirofumi Nagai, Tsutomu Shimada, Yoshimitsu Takahashi, Mikako Nishikawa, Hiroyuki Tozuka, Yasuto Yamamoto, Osamu Niwa, Yutaka Takahara, Arimi Fujita, Katsuhiko Nagase, Kazuo Kasahara, Seiji Yano and Yoshimichi Sai
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:28
    Content type: Research article Published on:
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Journal of Pharmaceutical Health Care and Sciences

ISSN: 2055-0294

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