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  1. Content type: Case report

    The advent of well-tolerated and effective anti-retroviral drugs against human immunodeficiency virus-1 (HIV-1) infection has been a major step forward that has achieved long-term survival in recent years. The...

    Authors: Takefumi Suzuki, Nobuko Hara, Morichika Osa, Kazuhisa Misawa, Kazuo Imai, Yuji Fujikura, Takuya Maeda, Wataru Sonehara and Akihiko Kawana

    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:23

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  2. Content type: Research article

    As of 2014, community pharmacies in Japan are approved by the Ministry of Health, Labour and Welfare to measure lipid panel, HbA1c, glucose, ALT, AST and γ-GTP, but not to screen for influenza virus. We provid...

    Authors: Akio Kawachi, Yusuke Sakamoto, Shunya Mouri, Mitsuaki Fukumori, Riku Kawano, Takaya Murakami, Junichiro Sonoda, Keiko Narumi, Yoshihiro Shimodozono, Kenji Etoh, Susumu Chiyotanda, Takashi Furuie, Keizo Sato, Masao Fukumori and Toshiro Motoya

    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:22

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  3. Content type: Research article

    In an evaluation of chemotherapy-induced peripheral neuropathy (CIPN), objectivity may be poor because the evaluation is determined by the patient’s subjective assessment. In such cases, management of neuropat...

    Authors: Junya Sato, Megumi Mori, Satoru Nihei, Satoshi Takeuchi, Masahiro Kashiwaba and Kenzo Kudo

    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:21

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  4. Content type: Research article

    In chemotherapy, the full round of treatment must be completed as scheduled to achieve the strongest therapeutic effect. However, peripheral neuropathy, a severe side effect of the chemotherapeutic agent pacli...

    Authors: Ken Konaka, Kota Moriyama, Takumi Sakurada, Naoto Okada, Masaki Imanishi, Yoshito Zamami, Kazuyoshi Kawazoe, Shuji Fushitani and Keisuke Ishizawa

    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:20

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  5. Content type: Research article

    Drug-induced gingival hyperplasia (DIGH) causes problems with chewing, aesthetics, and pronunciation, and leads to the deterioration of the patient’s quality of life (QOL). Thus, the aim of this study was to e...

    Authors: Haruna Hatahira, Junko Abe, Yuuki Hane, Toshinobu Matsui, Sayaka Sasaoka, Yumi Motooka, Shiori Hasegawa, Akiho Fukuda, Misa Naganuma, Tomofumi Ohmori, Yasutomi Kinosada and Mitsuhiro Nakamura

    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:19

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  6. Content type: Research article

    Human papillomavirus (HPV) vaccines have been shown to be effective for the eradication of HPV and prevention of cervical cancer. However, the number of women who receive HPV vaccinations has decreased over th...

    Authors: Yukari Ogawa, Hinako Takei, Ryuichi Ogawa and Kiyoshi Mihara

    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:18

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  7. Content type: Research article

    The optimal dose of mycophenolate mofetil (MMF) in renal transplant patients has been recommended to be decided on the basis of area under the concentration-time curve (AUC0-12) of mycophenolic acid (MPA). Althou...

    Authors: Tomoyuki Enokiya, Kouhei Nishikawa, Yuichi Muraki, Takuya Iwamoto, Hideki Kanda, Yoshiki Sugimura and Masahiro Okuda

    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:17

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  8. Content type: Research article

    Certain amount of anticancer drugs is excreted in the urine of patients receiving anticancer drugs, and urinary scattering including anticancer drugs at excretion has become a route of anticancer drug contamin...

    Authors: Junya Sato, Haruka Ohkubo, Yuki Sasaki, Makoto Yokoi, Yasunori Hotta and Kenzo Kudo

    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:16

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  9. Content type: Research article

    Randomized controlled trials (RCTs) reported that resistant dextrin (RD) exerted pleiotropic effects on humans. However, limited information is available on the effects of RD for weight loss. We conducted a sy...

    Authors: Junichi Mukai, Yuta Tsuge, Michiko Yamada, Katsuya Otori and Koichiro Atsuda

    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:15

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  10. Content type: Research article

    Health foods have been widely sold and consumed in Japan. There has been an increase in reports of adverse effects in association with the expanding health food market. While health food-drug interactions are ...

    Authors: Takamitsu Sasaki, Yu Sato, Takeshi Kumagai, Kouichi Yoshinari and Kiyoshi Nagata

    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:14

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  11. Content type: Research article

    Medical gloves are an important piece of personal protective equipment that prevents exposure to antineoplastic agents. The permeability of medical gloves to antineoplastic agents is a crucial factor in the ap...

    Authors: Toyohito Oriyama, Takehito Yamamoto, Yoshitsugu Yanagihara, Katsuhiko Nara, Toshihide Abe, Katsuyoshi Nakajima, Takao Aoyama and Hiroshi Suzuki

    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:13

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  12. Content type: Research article

    The accuracy, safety and feasibility of, the compounding robot APOTECAchemo were evaluated in the clinical practice of Japan.

    Authors: Takuya Iwamoto, Takuya Morikawa, Miki Hioki, Hirofumi Sudo, Demis Paolucci and Masahiro Okuda

    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:12

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  13. Content type: Research article

    With the development of pharmacotherapy and radiotherapy, cancer treatment is being shifted from surgical to outpatient services, consequently increasing insurance-covered pharmacies’ frequency of dealing with...

    Authors: Manako Hanya, Yoshitake Kanno, Junko Akasaki, Keiko Abe, Kazuhiko Fujisaki and Hiroyuki Kamei

    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:11

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  14. Content type: Erratum

    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:10

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    The original article was published in Journal of Pharmaceutical Health Care and Sciences 2017 3:9

  15. Content type: Research article

    Low-dose aspirin irreversibly inhibits platelet cyclooxygenase-1 (COX-1) and suppresses platelet aggregation. It is effective for secondary prevention of cardiovascular events. Because nonsteroidal anti-inflam...

    Authors: Kenta Shibata, Yuuki Akagi, Naofumi Nozawa, Hitoshi Shimomura and Takao Aoyama

    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:9

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    The Erratum to this article has been published in Journal of Pharmaceutical Health Care and Sciences 2017 3:10

  16. Content type: Research article

    Nosocomial infection is one of the most common complications within health care facilities. Certain studies have reported outbreaks resulting from contaminated hospital environments. Although the identificatio...

    Authors: Akihiro Manaka, Yutaka Tokue and Masami Murakami

    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:8

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  17. Content type: Research article

    Methotrexate (MTX) and salazosulfapyridine (SASP) are disease-modifying drugs that are commonly used in the treatment of rheumatoid arthritis (RA), and combination therapy with MTX and SASP is recommended for ...

    Authors: Morihiro Okada, Hiroshi Fujii, Yukio Suga, Satoshi Morito, Masae Okada, Jun Nishigami, Mitsuhiro Kawano, Tsutomu Shimada and Yoshimichi Sai

    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:7

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  18. Content type: Research article

    The aims of this study were to investigate predictive factors involved in effectiveness and safety of enoxaparin for prevention of postoperative venous thromboembolism in aged Japanese total knee arthroplasty ...

    Authors: Akihiro Sonoda, Yuki Kondo, Yasuhiro Tsuneyoshi, Yoshitaka Iwashita, Shoji Nakao, Kazuhisa Ishida, Kentaro Oniki, Junji Saruwatari, Tetsumi Irie and Yoichi Ishitsuka

    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:6

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  19. Content type: Research article

    An optimal inhalation flow pattern is essential for effective use of a dry powder inhaler (DPI). We wondered whether DPI instructors inhale from a DPI with an appropriate pattern, and if not, whether self-trai...

    Authors: Tetsuri Kondo, Makoto Hibino, Toshimori Tanigaki, Stanley M. Cassan, Sakurako Tajiri and Kenichro Akazawa

    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:5

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  20. Content type: Research article

    Appropriate prescription of dabigatran etexilate methanesulfonate (JAN) is more complicated than assumed, because there are totally 10 items of contraindications and instructions for dosage reduction depending...

    Authors: Teppei Shimizu, Yoshio Momose, Ryuichi Ogawa, Masahiro Takahashi and Hirotoshi Echizen

    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:4

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  21. Content type: Research article

    Bladder cancer patients receiving methotrexate, vinblastine, adriamycin and cisplatin (MVAC) chemotherapy are co-administered with dexamethasone as an anti-emetic. We examined whether or not dexamethasone affe...

    Authors: Shingo Itai, Yukio Suga, Yusuke Hara, Kouji Izumi, Yuji Maeda, Yasuhide Kitagawa, Junko Ishizaki, Tsutomu Shimada, Atsushi Mizokami and Yoshimichi Sai

    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:3

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  22. Content type: Research article

    Medication self-management in stroke patients is important to prevent further progression of disease and incidence of side effects. The purpose of this study was to create a formula for predicting medication s...

    Authors: Hisato Fujihara, Mari Kogo, Isao Saito, Nobuyuki Kawate, Masazumi Mizuma, Hiroko Suzuki, Jun-ichiro Murayama and Tadanori Sasaki

    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:2

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  23. Content type: Research article

    Few studies have reported the dosage of cefmetazole (CMZ) for intraoperative antimicrobial prophylaxis in patients underwent surgery for colorectal cancer. We therefore examined the optimal intraoperative dosa...

    Authors: Atsushi Tomizawa, Takatoshi Nakamura, Toshiaki Komatsu, Hiroshi Inano, Rumiko Kondo, Masahiko Watanabe and Koichiro Atsuda

    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:1

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  24. Content type: Research article

    Methotrexate (MTX) is currently the anchor drug widely used worldwide in the treatment of rheumatoid arthritis (RA). However, the therapeutic response to MTX has been shown to vary widely among individuals, ge...

    Authors: Masayuki Hashiguchi, Mikiko Shimizu, Jun Hakamata, Tomomi Tsuru, Takanori Tanaka, Midori Suzaki, Kumika Miyawaki, Takeshi Chiyoda, Osamu Takeuchi, Jiro Hiratsuka, Shin Irie, Junya Maruyama and Mayumi Mochizuki

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:35

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  25. Content type: Research article

    Hyperphosphatemia is one of the common complications in patients undergoing hemodialysis. Although calcium carbonate (CaC) is often used to control serum inorganic phosphorus level in dialysis patients, co-adm...

    Authors: Masaomi Tatsuzawa, Ryuichi Ogawa, Atsushi Ohkubo, Kazuyo Shimojima, Kunimi Maeda, Hirotoshi Echizen and Akihisa Miyazaki

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:34

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  26. Content type: Research article

    There are currently no promising therapies available to treat or prevent peripheral neuropathy (PN) induced by anticancer drugs in a cumulative dose-dependent manner. In this study, we investigated the efficac...

    Authors: Junya Sato, Megumi Mori, Satoru Nihei, Masumi Kumagai, Satoshi Takeuchi, Masahiro Kashiwaba and Kenzo Kudo

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:33

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  27. Content type: Research article

    The coreceptor tropism testing should be conducted prior to commencing a regimen containing a CCR5 antagonist for treatment of HIV-1 infection. For aviremic patients on long antiretroviral therapy, proviral DN...

    Authors: Hiroshi Kotani, Koji Sudo, Naoki Hasegawa, Hiroshi Fujiwara, Tomohisa Hayakawa, Osamu Iketani, Masaya Yamaguchi, Mayumi Mochizuki, Satoshi Iwata and Shingo Kato

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:31

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  28. Content type: Research article

    Consideration of medical costs as well as effectiveness and adverse events is rapidly been becoming an important factor in the selection of chemotherapy regimens. However, practical data on the costs of chemot...

    Authors: Kosuke Takata, Ken-ichi Fujita, Yutaro Kubota, Hiroo Ishida, Wataru Ichikawa, Ken Shimada, Takashi Sekikawa, Iori Taki-Takemoto, Daisuke Kamei, Shinichi Iwai and Yasutsuna Sasaki

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:30

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  29. Content type: Research article

    Pregabalin is recommended as an adjuvant analgesic for neuropathic cancer-related pain, and may be taken at all steps of the World Health Organization analgesic ladder. However, unlike opioids, pregabalin trea...

    Authors: Ryo Yajima, Kazuaki Matsumoto, Yuya Ise, Norihito Suzuki, Yuta Yokoyama, Junko Kizu and Shiro Katayama

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:29

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  30. Content type: Research article

    The exposure of healthcare workers to anticancer drugs such as cyclophosphamide (CPA) is a serious health concern. Anticancer drug pollution may spread outside biological safety cabinets even when a closed sys...

    Authors: Junya Sato, Atushi Kogure and Kenzo Kudo

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:28

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  31. Content type: Research article

    It is well-documented that chronic kidney disease (CKD) often results in end-stage renal failure and puts patients at extremely high risk for developing cardiovascular disease. Educational hospitalization at m...

    Authors: Eiji Kose, Taesong An, Akihiko Kikkawa and Hiroyuki Hayashi

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:27

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  32. Content type: Research article

    Exposure to anticancer drugs is hazardous and may lead to chromosomal abnormalities and spontaneous abortion in healthcare workers. Guidelines recommend surface decontamination and cleaning in order to minimiz...

    Authors: Ayumi Tsukamoto, Shunji Ishiwata, Asami Kajimoto, Ryusuke Murata, Rika Kitano, Tomomi Inoue and Takeshi Kotake

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:26

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  33. Content type: Research article

    This study aimed to develop a simultaneous determination method for tramadol and its desmethylates in human plasma using isocratic liquid chromatography coupled to tandem mass spectrometry and to validate it f...

    Authors: Hironari Tanaka, Takafumi Naito, Yasuaki Mino and Junichi Kawakami

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:25

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  34. Content type: Research article

    Taxanes are known to cause onychopathy. Previous studies have reported the relationship between onychopathy and paclitaxel dosing intervals and cumulative doses. However, there are no studies of the predictive...

    Authors: Hidenobu Takahata, Kouichi Tanabe, Akiyoshi Takaki, Tsuneaki Yamanouchi, Yasuhiko Mimura, Atsumi Nitta, Hatsuna Yasuda, Tatsuhiko Kashii and Isao Adachi

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:24

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  35. Content type: Short report

    Hypomagnesemia is one of the characteristic side effects of the human anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, cetuximab and panitumumab.

    Authors: Toshiyasu Tsujii, Takafumi Ogaki, Kaori Nakae, Kiyotaka Imai, Daisuke Kise, Shoji Tada, Hiroki Ueda and Masahiro Moriyama

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:23

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  36. Content type: Research article

    Plasma tenofovir (TFV) trough concentrations may be relevant for tenofovir disoproxil fumarate (TDF)-induced renal dysfunction. The purpose of this study was to determine the association between plasma TFV tro...

    Authors: Yusuke Kunimoto, Hiroshi Ikeda, Satoshi Fujii, Manabu Kitagawa, Kieko Yamazaki, Hiromasa Nakata, Norimasa Noda, Tadao Ishida and Atsushi Miyamoto

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:22

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  37. Content type: Research article

    A new formulation of olanzapine available for terminally ill patients is needed. Rectal administration using suppositories is an alternative for patients for whom administration via the oral route is not feasi...

    Authors: Kazuaki Matsumoto, Satoru Kimura, Kenichi Takahashi, Yuta Yokoyama, Masayuki Miyazawa, Satoko Kushibiki, Morio Katamachi and Junko Kizu

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:20

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  38. Content type: Research article

    Many pharmacists are participating in team-based medical care in emergency hospitals. Therefore, there is a desperate need to improve the education system. In the present study, we provided a “pharmaceutical l...

    Authors: Yoshito Zamami, Toru Imai, Masaki Imanishi, Kenshi Takechi, Naoko Shiraishi, Toshihiro Koyama, Hidenori Sagara, Yasukazu Shiino, Toshiaki Sendo and Keisuke Ishizawa

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:21

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  39. Content type: Research article

    Sivelestat, a neutrophil elastase inhibitor, was previously approved in Japan for the treatment of acute lung injury associated with systemic inflammatory response syndrome. However, sivelestat produced incons...

    Authors: Takuma Ozawa, Kiyoshi Mihara and Nobuhiro Yasuno

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:19

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  40. Content type: Research article

    We investigated the pharmacokinetics of etoposide (ETP) to reduce the inter-individual variations of ETP concentrations in patients with acute leukemia who underwent allogeneic hematopoietic stem cell transpla...

    Authors: Yuki Tazawa, Akio Shigematsu, Kumiko Kasashi, Junichi Sugita, Tomoyuki Endo, Takeshi Kondo, Takanori Teshima, Ken Iseki, Mitsuru Sugawara and Yoh Takekuma

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:18

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  41. Content type: Research article

    Catheter ablation is a non-medication therapy for atrial fibrillation, and during the procedure, warfarin is withdrawn in the preoperative period to prevent the risk of bleeding. In case of emergency, vitamin K2 ...

    Authors: Zhi Zhou, Ikuko Yano, Sumiko Odaka, Yosuke Morita, Satoshi Shizuta, Mamoru Hayano, Takeshi Kimura, Akinori Akaike, Ken-ichi Inui and Kazuo Matsubara

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:17

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  42. Content type: Research article

    Genotype frequencies for chemotherapy-induced nausea and vomiting (CINV)-related polymorphisms have not yet been reported for Japanese subjects.

    Authors: Aya Goto, Haruka Kotani, Masayuki Miyazaki, Kiyofumi Yamada, Kazuhiro Ishikawa, Yasuhiko Shimoyama, Toshimitsu Niwa, Yoshinori Hasegawa and Yukihiro Noda

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:16

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  43. Content type: Case report

    Regorafenib and its metabolites may inhibit the activities of several CYP or UDP-glucuronosyltransferase isoforms, including that of CYP2C9. Therefore, pharmacological agents that are CYP2C9 substrates may sho...

    Authors: Hironori Kitade, Azusa Hiromasa-Yamasaki, Kengo Hokkoku, Mitsue Mori, Michio Watanabe, Masuo Nakai and Seiji Yano

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:15

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  44. Content type: Research article

    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse reactions associated with fatal disorders. Although many causes of SJS/TEN have been proposed, the time-to-onset...

    Authors: Junko Abe, Ryogo Umetsu, Kanako Mataki, Yamato Kato, Natsumi Ueda, Yoko Nakayama, Yuuki Hane, Toshinobu Matsui, Haruna Hatahira, Sayaka Sasaoka, Yumi Motooka, Hideaki Hara, Zenichiro Kato, Yasutomi Kinosada, Naoki Inagaki and Mitsuhiro Nakamura

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:14

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  45. Content type: Research article

    Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic inflammatory status, joint destruction, disability, and pain. Methotrexate (MTX) has been confirmed to reduce disease activit...

    Authors: Masayuki Hashiguchi, Tomomi Tsuru, Kumika Miyawaki, Midori Suzaki, Jun Hakamata, Mikiko Shimizu, Shin Irie and Mayumi Mochizuki

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:13

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  46. Content type: Research article

    We formulated mianserin suppositories for the treatment of delirium and evaluated their pharmacokinetics by measuring plasma drug concentrations in dogs and healthy human volunteers.

    Authors: Shuichi Nawata, Noriko Kohyama, Naoki Uchida, Satoshi Numazawa, Masayuki Ohbayashi, Yasuna Kobayashi, Masanori Iwata, Takanori Nakajima, Hiroshi Saito, Akira Izuka and Toshinori Yamamoto

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:12

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  47. Content type: Research article

    Osteoporosis is estimated to afflict over 200 million people worldwide and healthcare professionals are needed to successfully intervene. The aim of this study was to assess cognitive changes in students perta...

    Authors: Erisa Tomishige-Mukai, Akio Kawachi, Erika Kiyohara, Fuminori Esaki, Junichiro Sonoda, Tomohiro Shinya, Keiko Narumi, Keizo Sato and Toshiro Motoya

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:11

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  48. Content type: Research article

    Voriconazole concentrations display a large variability, which cannot completely be explained by known factors. We investigated the relationships of voriconazole concentration with patient-specific variables a...

    Authors: Satoshi Dote, Maki Sawai, Ayumu Nozaki, Kazumasa Naruhashi, Yuka Kobayashi and Hirokazu Nakanishi

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:10

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  49. Content type: Research article

    This study was designed to evaluate the population pharmacokinetics (popPK) of penicillin G in patients with infective endocarditis and establish a dosage regimen based on pharmacokinetic data and clinical out...

    Authors: Toshiaki Komatsu, Takayuki Inomata, Ichiro Watanabe, Masahiro Kobayashi, Hideya Kokubun, Junya Ako and Koichiro Atsuda

    Citation: Journal of Pharmaceutical Health Care and Sciences 2016 2:9

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