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  1. Combination therapy with tazobactam/ceftolozane (TAZ/CTLZ) and high-dose aminoglycosides has been reported to be efficacious in extensively drug-resistant (XDR)-Pseudomonas aeruginosa infection. However, there ar...

    Authors: Yuta Ibe, Ryuichiro Kakizaki, Hirotoshi Inamura, Tomoyuki Ishigo, Yoshihiro Fujiya, Hiroyuki Inoue, Shuji Uemura, Satoshi Fujii, Satoshi Takahashi, Eichi Narimatsu and Masahide Fukudo
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:25
  2. Olanzapine treatment prevents chemotherapy-induced nausea and vomiting (CINV) in patients receiving highly emetogenic chemotherapy (HEC). However, its role in the secondary prevention of breakthrough CINV in r...

    Authors: Akihiro Uchiike, Haruka Kono, Katsuhiro Miura, Tatsuya Hayama, Daisuke Tsutsumi, Shinya Tsuboi, Susumu Ohtsuka and Shinji Hidaka
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:24
  3. In Japan, the use of risperidone in combination with adrenaline is contraindicated, except in cases of anaphylaxis. Therefore, there is limited clinical evidence regarding the interaction of these two drugs. H...

    Authors: Takafumi Nakano, Yoshihiko Nakamura, Keisuke Sato, Yoshito Izutani, Hiroto Iyota, Misaki Aoyagi, Taisuke Kitamura, Toshinobu Hayashi, Koichi Matsuo, Kenichi Mishima, Hidetoshi Kamimura, Hiroyasu Ishikura and Takashi Egawa
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:23
  4. While cancer is a risk factor for developing thromboembolism, so is the use of molecularly targeted therapies. This study aimed to determine whether thromboembolism incidence differed between vascular endothel...

    Authors: Ryo Takada, Miki Fujiwara, Masatoshi Maki, Yoko Takahashi and Koji Tamura
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:22
  5. The immersing powdered crude drugs (IPCD) method is a quick and simple method for preparing decoctions. Here, the conventional and IPCD methods were compared for the color and extraction of quantitative indica...

    Authors: Kazumasa Naruhashi, Natsumi Amaike, Karen Shiraishi, Sumire Sato, Chiho Uryuzu, Yui Saito and Narumi Tsue
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:21
  6. It is important to design an effective formulation to enhance the skin penetration, and nanotechnologies have been used in dermal and transdermal drug delivery. In this study, we prepared formulations (gels) c...

    Authors: Reita Kadowaki, Fumihiko Ogata, Aoi Fushiki, Saki Daimyo, Saori Deguchi, Hiroko Otake, Mayumi Nagata, Hiroshi Sasaki, Naohito Kawasaki and Noriaki Nagai
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:20
  7. Insulin treatment is widely used not only for type 1 but also for type 2 diabetes patients. Insulin must be injected into the subcutaneous tissue to be effective. The needle length has been shortened for safet...

    Authors: Aya Torii-Goto, Kana Hirai, Yuri Inukai, Yoshimi Hoshina, Kazumi Shiomi, Junko Ito and Masae Yoshikawa
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:19
  8. Erythrocyte transfusion is an indispensable component of supportive care after hematopoietic stem cell transplantation (HSCT). However, HSCT recipients are susceptible to the development of acute kidney injury...

    Authors: Hirokazu Nakayama, Yoshimasa Kamoda, Michiya Tanuma, Toshiaki Kato and Kensuke Usuki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:18
  9. High-flow continuous hemodiafiltration (HF-CHDF) combines diffusive and convective solute removal and is employed for artificial liver adjuvant therapy. However, there is no report on dosage planning of vancom...

    Authors: Yuriko Ito, Junya Nakade, Akihiro Seki, Ryosuke Gabata, Mitsuyoshi Okazaki, Shinichi Nakanuma, Arimi Fujita, Tsutomu Shimada, Taro Yamashita, Shintaro Yagi, Takumi Taniguchi and Yoshimichi Sai
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:15
  10. Alectinib, crizotinib, and ceritinib, are anaplastic lymphoma kinase-tyrosine kinase inhibitors (ALK-TKIs) that exhibit high protein binding, and their metabolism is associated with the cytochrome P450 (CYP) i...

    Authors: Takashi Kato, Yusuke Kunimoto, Manabu Kitagawa, Yuichiro Asai, Tomoko Kimyo, Hiromasa Nakata, Mamoru Takahashi, Hirofumi Chiba, Hiroki Takahashi, Atsushi Miyamoto and Masahide Fukudo
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:14
  11. Authors: Shinya Tsuboi, Tatsuya Hayama, Katsuhiro Miura, Akihiro Uchiike, Daisuke Tsutsumi, Takashi Yamauchi, Yoshihiro Hatta and Susumu Ootsuka
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:16

    The original article was published in Journal of Pharmaceutical Health Care and Sciences 2023 9:2

  12. Rhabdomyolysis is a potentially life-threatening disease caused by melting or necrosis of skeletal muscle cells and leakage of muscle components into the bloodstream. It has been reported that the interaction ...

    Authors: Keiki Sakurama, Yuki Iguchi, Sara Haruki, Yusuke Hata, Madoka Hiraga, Shinya Yumoto and Yutaka Kai
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:13

    The Correction to this article has been published in Journal of Pharmaceutical Health Care and Sciences 2023 9:17

  13. Drug-drug interaction management is complex. Nirmatrelvir/ritonavir is a potent cytochrome P450 (CYP) 3A inhibitor and influences pharmacokinetics of co-administered drugs. Although there are several reports a...

    Authors: Ayumi Tsuzawa, Yoshiki Katada, Keisuke Umemura, Mitsuhiro Sugimoto, Asami Nishikawa, Yu-ki Sato, Yuko Yoshida, Noriaki Kitada, Atsushi Yonezawa, Daisuke Nakajima, Hiroshi Date and Tomohiro Terada
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:12
  14. Fluconazole (FLCZ) inhibits cytochrome P450 (CYP) 2C9, 2C19, and 3A4 and has a drug-drug interaction that potentiates the effects of warfarin and prolong the prothrombin time-international normalized ratio (PT...

    Authors: Hayato Akamatsu, Hiroo Nakagawa, Ichiro Matsumaru, Junya Hashizume, Hitomi Harasawa, Yukinobu Kodama, Takashi Miura and Kaname Ohyama
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:11
  15. Polypharmacy, defined as the concurrent use of over six drugs, is common in the treatment of heart failure (HF); however, unpredictable drug interactions with bepridil may occur. In this study, we have elucida...

    Authors: Yuki Asai, Hiroki Arihara, Saki Omote, Ena Tanio, Saena Yamashita, Takashi Higuchi, Ei Hashimoto, Momoko Yamada, Hinako Tsuji, Yoshihiro Kondo, Makoto Hayashi and Yoshiaki Yamamoto
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:10
  16. Supporting people living with HIV using anti-retroviral therapy (ART) is important due to the requirement for strict medication adherence. To date, no data from longitudinal studies evaluating adherence by tre...

    Authors: Yusuke Sekine, Takashi Kawaguchi, Yusuke Kunimoto, Junichi Masuda, Ayako Numata, Atsushi Hirano, Hiroki Yagura, Masashi Ishihara, Shinichi Hikasa, Mariko Tsukiji, Tempei Miyaji, Takuhiro Yamaguchi, Ei Kinai and Kagehiro Amano
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:9
  17. There is no unified view of the necessity of prophylactic antimicrobial agents in trabeculectomy. Preoperative prophylactic antimicrobial agent injection and cefazolin sodium (CEZ) for trabeculectomy were disc...

    Authors: Yuuka Ushio, Hiroshi Yoshikawa, Tetsuya Murase, Tatsuo Kataoka, Shohei Miyamoto, Kazunari Maruko, Shoko Okamoto, Yuuka Shibata, Ryotaro Toda, Yoshiaki Kiuchi and Hiroaki Matsuo
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:8
  18. Cancer-related fatigue (CRF) is one of the most common symptoms in patients with cancer. However, CRF has not been sufficiently evaluated as it involves various factors. In this study, we evaluated fatigue in ...

    Authors: Takuya Fujihara, Motohiko Sano, Yutaka Negoro, Shinji Yamashita, Hideya Kokubun and Ryoichi Yano
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:7
  19. One-dose packaging is frequently used in Japan for elderly patients who are prescribed several medications. It is useful for easy administration and the prevention of misuse or missed medications. Hygroscopic ...

    Authors: Taisuke Matsuo, Takayuki Yoshida, Kiyotaka Ushijima, Takashi Doi, Yasuyuki Sadzuka and Takashi Tomita
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:6
  20. We aimed to evaluate the factors associated with baloxavir prescription in Japanese hospitals using a health insurance claim-based database (MDV analyzer), during the 2018/2019 and 2019/2020 influenza seasons....

    Authors: Naomi Fujiwara, Takashi Fujiwara and Yuya Ise
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:3
  21. For pharmacists expected to encounter the deaths of many of their patients in the near future, it is important to understand the perception of a “good death” for patients with cancer who are likely to be aware...

    Authors: Reiko Konishi, Junichi Isogai, Akira Mukai, Koji Komori, Takashi Majima, Shinji Ito and Kou Kawada
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:5
  22. Dasatinib, which is used to treat treating chronic myeloid leukemia, induces increases in blood lymphocytes during the treatment. In addition, neutrophil–lymphocyte count ratio (NLR) is associated with the rel...

    Authors: Hirokazu Nakayama, Hiromitsu Iizuka, Toshiaki Kato and Kensuke Usuki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:4
  23. Pegfilgrastim is widely used for the prevention of febrile neutropenia (FN) in patients receiving myelosuppressive chemotherapy for various types of cancer. However, pegfilgrastim-induced bone pain (PIBP) is a...

    Authors: Shinya Tsuboi, Tatsuya Hayama, Katsuhiro Miura, Akihiro Uchiike, Daisuke Tsutsumi, Takashi Yamauchi, Yoshihiro Hatta and Susumu Ootsuka
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:2

    The Correction to this article has been published in Journal of Pharmaceutical Health Care and Sciences 2023 9:16

  24. Mycophenolate mofetil (MMF), a prodrug of the immunosuppressive agent mycophenolic acid (MPA), is difficult to administer because of the pharmacokinetic complexity of MPA. Although dosage adjustment according ...

    Authors: Tomoko Mizaki, Hironobu Nobata, Shogo Banno, Makoto Yamaguchi, Hiroshi Kinashi, Shiho Iwagaitsu, Takuji Ishimoto, Yukiko Kuru, Masafumi Ohnishi, Ken-ichi Sako and Yasuhiko Ito
    Citation: Journal of Pharmaceutical Health Care and Sciences 2023 9:1
  25. Long-term use of proton pump inhibitors (PPIs) has been found to significantly lower serum magnesium levels in patients in the USA and Europe. The package inserts of PPIs in these countries clearly state that ...

    Authors: Nobuhiko Nakamura, Kanaha Yoneda, Takashi Higo and Masaaki Kusumoto
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:35
  26. The number of medications, number of administrations per day, dosing frequency on indicated day, and medication from multiple prescriptions are the medication factors prone to medication errors in self-managem...

    Authors: Ryohei Suzuki, Takako Uchiya, Takamasa Sakai, Masaaki Takahashi and Fumiko Ohtsu
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:37
  27. Human soluble recombinant thrombomodulin (TM alfa), a treatment for septic Disseminated intravascular coagulation (DIC), is recommended for patients with severe renal dysfunction in reduced doses. However, no ...

    Authors: Yoshihiro Nishita, Masatoshi Taga, Masaru Sakurai, Yoshitsugu Iinuma and Togen Masauji
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:32
  28. Inappropriate medication prescribing and dispensing by physicians and pharmacists is a preventable cause of morbidity and mortality in the elderly. Signifying the importance of healthcare professionals’ knowle...

    Authors: Wuraola Akande-Sholabi and Adeola Fafemi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:36
  29. Allopurinol is used to treat hyperuricemia and gout. It is metabolized to oxypurinol by xanthine oxidase (XO), and aldehyde oxidase (AO). Allopurinol and oxypurinol are potent XO inhibitors that reduce the pla...

    Authors: Yoshitaka Tayama, Kazumi Sugihara, Seigo Sanoh, Katsushi Miyake, Shigeyuki Kitamura and Shigeru Ohta
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:31
  30. During the coronavirus disease (COVID-19) pandemic, general strategies for preventing infectious diseases, such as social distancing and the use of protective equipment have resulted in communication barriers ...

    Authors: Masaki Maehara and Masayasu Sugiyama
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:34
  31. Immunotherapy with immune checkpoint inhibitors is associated with immune-related adverse events (irAEs). A positive correlation between treatment efficacy and irAEs has been reported. Clinical indicators are ...

    Authors: Maiko Machida, Chika Yamazaki, Nao Kouda, Yousei Hanai, Hideki Sato, Ainari Konda, Yuka Yamagata, Tatsuya Itho and Haruhiko Aisaka
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:29
  32. Gefitinib and erlotinib, are epidermal growth factor receptor tyrosine kinase inhibitors, and are currently recommended for non-small cell lung cancer stage IV in the elderly and in patients with decreased per...

    Authors: Hirofumi Nagai, Tsutomu Shimada, Yoshimitsu Takahashi, Mikako Nishikawa, Hiroyuki Tozuka, Yasuto Yamamoto, Osamu Niwa, Yutaka Takahara, Arimi Fujita, Katsuhiko Nagase, Kazuo Kasahara, Seiji Yano and Yoshimichi Sai
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:28
  33. The impact of cumulative dose of cisplatin on gonadal function has not been clarified. We evaluated whether the cumulative cisplatin dose affects the resumption of menses in patients treated with bleomycin, et...

    Authors: Miki Akasaka, Toshinori Hirai, Kenta Yoshida, Eiji Kondo, Tomoaki Ikeda and Takuya Iwamoto
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:33
  34. Information sharing among medical professionals is important for providing quality medical care. The purpose of the present study was to elucidate the actual status of information sharing between hospitals and...

    Authors: Daisuke Kikuchi, Masami Tsuchiya, Shiro Hatakeyama, Yuichi Tasaka, Takeshi Uchikura, Ryohkan Funakoshi and Taku Obara
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:30
  35. COVID-19 has become a significant health threat and a primary healthcare concern among the most vulnerable patients with cancer. Patients with COVID-19 who have lung cancer are at great risk and need careful m...

    Authors: Masatoshi Maki, Ryo Takada, Akihiko Taniguchi, Naoyuki Nomura, Seiichiro Kuramoto, Yuki Chiko, Toshiaki Okada, Seiji Saito and Koji Tamura
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:27
  36. It is possible that increased synthesis of metallothioneins (MTs), Zn2+-binding proteins is linked with the protective effect of Ninjin-yoei-to (NYT) on Zn2+ toxicity ferried by amyloid β1-42 (Aβ1-42).

    Authors: Haruna Tamano, Haruna Tokoro, Daichi Murakami, Rin Tsujimoto, Yuka Nishijima, Erina Tsuda, Satoshi Watanabe, Miki Suzuki and Atsushi Takeda
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:26
  37. Tacrolimus is a key drug in immunosuppressive therapy following lung transplantation. The blood tacrolimus levels are likely to fluctuate in the early postoperative period, and failure to maintain the tacrolim...

    Authors: Yoshiki Katada, Shunsaku Nakagawa, Kotaro Itohara, Takuya Suzuki, Ryota Kato, Hiroki Endo, Mitsuhiro Sugimoto, Atsushi Yonezawa, Takayuki Nakagawa, Akihiro Ohsumi, Daisuke Nakajima, Hiroshi Date and Tomohiro Terada
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:25
  38. Although automated dispensing robots have been implemented for medication dispensing in Japan, their effect is yet to be fully investigated. In this study, we evaluated the effect of automated dispensing robot...

    Authors: Tomoki Takase, Norio Masumoto, Naoki Shibatani, Yusaku Matsuoka, Fumiaki Tanaka, Masaki Hirabatake, Hiroko Kashiwagi, Itaru Nishioka, Hiroaki Ikesue, Tohru Hashida, Naoshi Koide and Nobuyuki Muroi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:24
  39. Pharmacists must understand the mechanisms by which dispensing errors occur and take appropriate preventive measures. In this study, the gaze movements of pharmacists were analyzed using an eye-tracking method...

    Authors: Toshikazu Tsuji, Kenichiro Nagata, Keiichi Sasaki, Ryosuke Matsukane, Shigeru Ishida, Takehiro Kawashiri, Kimitaka Suetsugu, Hiroyuki Watanabe, Takeshi Hirota and Ichiro Ieiri
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:23
  40. We previously reported that high body weight was a risk factor affecting the onset of anti-epidermal growth factor receptor (EGFR) antibody drug-induced acneiform rash. The current study investigated the relat...

    Authors: Hiroaki Takahashi, Yukiko Yaegashi, Yoko Saito, Satoru Nihei, Tomohiko Tairabune, Haruki Ujiie, Junichi Asaka and Kenzo Kudo
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:22
  41. Cisplatin (CDDP)-induced nephrotoxicity is the most important complication of CDDP treatment. 5-Hydroxytryptamine type 3 receptor antagonists (5-HT3RAs) are widely used to prevent chemotherapy-induced nausea and ...

    Authors: Miho Takemura, Kenji Ikemura, Masayoshi Kondo, Fumihiro Yamane, Mikiko Ueda and Masahiro Okuda
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:21
  42. Sulfamethoxazole/trimethoprim (SMX/TMP) potentially increases the serum creatinine levels, resulting in acute kidney injury (AKI). However, the clinical characteristics of the AKI associated with SMX/TMP and t...

    Authors: Yuki Shimizu, Toshinori Hirai, Yukari Ogawa, Chihiro Yamada and Emiko Kobayashi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:20
  43. Patients with ulcerative colitis (UC) may be concerned about medication safety during preconception, pregnancy, and lactation, and they should be closely followed up to ensure that UC activity is controlled du...

    Authors: Jumpei Saito, Kayoko Kaneko, Hiroyo Kawasaki, Takeshi Hayakawa, Naho Yakuwa, Tomo Suzuki, Haruhiko Sago, Akimasa Yamatani and Atsuko Murashima
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:18
  44. Linezolid is a new oxazolidinone antibiotic used for infections caused by methicillin-resistant Staphylococcus and other species.

    Authors: Daisuke Negishi, Okimichi Mitsumatsu, Takahiro Matsumura, Hiromi Mitsumatsu, Miaki Makiguchi, Makiko Shimizu and Hiroshi Yamazaki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:16
  45. In Japan, engineering controls for preparing injectable anticancer drugs are inadequate and compliance with appropriate preparation procedures is vital. In this study, we evaluated the effects of adherence to ...

    Authors: Yuki Yanagisawa, Kazuo Isama, Tomohiro Kurosu, Yoshiaki Natsume, Toshikazu Seino, Tetsuji Nishimura and Atsushi Yamashita
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:19
  46. Nelarabine is an antineoplastic purine analog used for the treatment of refractory or relapsed T-cell acute lymphoblastic leukemia (T-ALL). The most prominent side effect of nelarabine are neurotoxicity and he...

    Authors: Akari Utsumi, Yuri Goto, Takaaki Suzuki, Chiaki Imai, Shinichiro Matsui, Emiko Sakaida and Itsuko Ishii
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:17
  47. Olanzapine has been shown to have an additive effect on the three-drug antiemetic therapy consisting of aprepitant, palonosetron, and dexamethasone, in a highly emetogenic cisplatin-containing chemotherapy. Al...

    Authors: Yu Kondo, Tomoya Tachi, Takayoshi Sakakibara, Jun Kato, Takahito Mizuno, Yoshio Miyake and Hitomi Teramachi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:15
  48. In the European Union (EU), a Risk Management Plan (RMP) is submitted as part of the dossier for initial marketing authorization of a medicinal product or with an application involving a significant change to ...

    Authors: Suzan Esslinger, Linda Quinn, Sami Sampat, Marijo Otero-Lobato, Wim Noël, Anja Geldhof, Nicole Herijgers and Sarah-Jane Reeder
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:14
  49. Acetaminophen-induced hypotension has been reported in critically ill patients; however, it remains unclear whether mannitol, present as a stabilizing compound in acetaminophen formulations, affects hemodynami...

    Authors: Shunsuke Inage, Ryo Yajima, Shintaro Nagahara, Aya Kazama, Moe Takamura, Tomohiro Shoji, Mika Kadoi, Yukiko Tashiro and Yuya Ise
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:13

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