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  1. The impact of cumulative dose of cisplatin on gonadal function has not been clarified. We evaluated whether the cumulative cisplatin dose affects the resumption of menses in patients treated with bleomycin, et...

    Authors: Miki Akasaka, Toshinori Hirai, Kenta Yoshida, Eiji Kondo, Tomoaki Ikeda and Takuya Iwamoto
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:33
  2. Information sharing among medical professionals is important for providing quality medical care. The purpose of the present study was to elucidate the actual status of information sharing between hospitals and...

    Authors: Daisuke Kikuchi, Masami Tsuchiya, Shiro Hatakeyama, Yuichi Tasaka, Takeshi Uchikura, Ryohkan Funakoshi and Taku Obara
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:30
  3. COVID-19 has become a significant health threat and a primary healthcare concern among the most vulnerable patients with cancer. Patients with COVID-19 who have lung cancer are at great risk and need careful m...

    Authors: Masatoshi Maki, Ryo Takada, Akihiko Taniguchi, Naoyuki Nomura, Seiichiro Kuramoto, Yuki Chiko, Toshiaki Okada, Seiji Saito and Koji Tamura
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:27
  4. It is possible that increased synthesis of metallothioneins (MTs), Zn2+-binding proteins is linked with the protective effect of Ninjin-yoei-to (NYT) on Zn2+ toxicity ferried by amyloid β1-42 (Aβ1-42).

    Authors: Haruna Tamano, Haruna Tokoro, Daichi Murakami, Rin Tsujimoto, Yuka Nishijima, Erina Tsuda, Satoshi Watanabe, Miki Suzuki and Atsushi Takeda
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:26
  5. Tacrolimus is a key drug in immunosuppressive therapy following lung transplantation. The blood tacrolimus levels are likely to fluctuate in the early postoperative period, and failure to maintain the tacrolim...

    Authors: Yoshiki Katada, Shunsaku Nakagawa, Kotaro Itohara, Takuya Suzuki, Ryota Kato, Hiroki Endo, Mitsuhiro Sugimoto, Atsushi Yonezawa, Takayuki Nakagawa, Akihiro Ohsumi, Daisuke Nakajima, Hiroshi Date and Tomohiro Terada
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:25
  6. Although automated dispensing robots have been implemented for medication dispensing in Japan, their effect is yet to be fully investigated. In this study, we evaluated the effect of automated dispensing robot...

    Authors: Tomoki Takase, Norio Masumoto, Naoki Shibatani, Yusaku Matsuoka, Fumiaki Tanaka, Masaki Hirabatake, Hiroko Kashiwagi, Itaru Nishioka, Hiroaki Ikesue, Tohru Hashida, Naoshi Koide and Nobuyuki Muroi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:24
  7. Pharmacists must understand the mechanisms by which dispensing errors occur and take appropriate preventive measures. In this study, the gaze movements of pharmacists were analyzed using an eye-tracking method...

    Authors: Toshikazu Tsuji, Kenichiro Nagata, Keiichi Sasaki, Ryosuke Matsukane, Shigeru Ishida, Takehiro Kawashiri, Kimitaka Suetsugu, Hiroyuki Watanabe, Takeshi Hirota and Ichiro Ieiri
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:23
  8. We previously reported that high body weight was a risk factor affecting the onset of anti-epidermal growth factor receptor (EGFR) antibody drug-induced acneiform rash. The current study investigated the relat...

    Authors: Hiroaki Takahashi, Yukiko Yaegashi, Yoko Saito, Satoru Nihei, Tomohiko Tairabune, Haruki Ujiie, Junichi Asaka and Kenzo Kudo
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:22
  9. Cisplatin (CDDP)-induced nephrotoxicity is the most important complication of CDDP treatment. 5-Hydroxytryptamine type 3 receptor antagonists (5-HT3RAs) are widely used to prevent chemotherapy-induced nausea and ...

    Authors: Miho Takemura, Kenji Ikemura, Masayoshi Kondo, Fumihiro Yamane, Mikiko Ueda and Masahiro Okuda
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:21
  10. Sulfamethoxazole/trimethoprim (SMX/TMP) potentially increases the serum creatinine levels, resulting in acute kidney injury (AKI). However, the clinical characteristics of the AKI associated with SMX/TMP and t...

    Authors: Yuki Shimizu, Toshinori Hirai, Yukari Ogawa, Chihiro Yamada and Emiko Kobayashi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:20
  11. Patients with ulcerative colitis (UC) may be concerned about medication safety during preconception, pregnancy, and lactation, and they should be closely followed up to ensure that UC activity is controlled du...

    Authors: Jumpei Saito, Kayoko Kaneko, Hiroyo Kawasaki, Takeshi Hayakawa, Naho Yakuwa, Tomo Suzuki, Haruhiko Sago, Akimasa Yamatani and Atsuko Murashima
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:18
  12. Linezolid is a new oxazolidinone antibiotic used for infections caused by methicillin-resistant Staphylococcus and other species.

    Authors: Daisuke Negishi, Okimichi Mitsumatsu, Takahiro Matsumura, Hiromi Mitsumatsu, Miaki Makiguchi, Makiko Shimizu and Hiroshi Yamazaki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:16
  13. In Japan, engineering controls for preparing injectable anticancer drugs are inadequate and compliance with appropriate preparation procedures is vital. In this study, we evaluated the effects of adherence to ...

    Authors: Yuki Yanagisawa, Kazuo Isama, Tomohiro Kurosu, Yoshiaki Natsume, Toshikazu Seino, Tetsuji Nishimura and Atsushi Yamashita
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:19
  14. Nelarabine is an antineoplastic purine analog used for the treatment of refractory or relapsed T-cell acute lymphoblastic leukemia (T-ALL). The most prominent side effect of nelarabine are neurotoxicity and he...

    Authors: Akari Utsumi, Yuri Goto, Takaaki Suzuki, Chiaki Imai, Shinichiro Matsui, Emiko Sakaida and Itsuko Ishii
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:17
  15. Olanzapine has been shown to have an additive effect on the three-drug antiemetic therapy consisting of aprepitant, palonosetron, and dexamethasone, in a highly emetogenic cisplatin-containing chemotherapy. Al...

    Authors: Yu Kondo, Tomoya Tachi, Takayoshi Sakakibara, Jun Kato, Takahito Mizuno, Yoshio Miyake and Hitomi Teramachi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:15
  16. In the European Union (EU), a Risk Management Plan (RMP) is submitted as part of the dossier for initial marketing authorization of a medicinal product or with an application involving a significant change to ...

    Authors: Suzan Esslinger, Linda Quinn, Sami Sampat, Marijo Otero-Lobato, Wim Noël, Anja Geldhof, Nicole Herijgers and Sarah-Jane Reeder
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:14
  17. Acetaminophen-induced hypotension has been reported in critically ill patients; however, it remains unclear whether mannitol, present as a stabilizing compound in acetaminophen formulations, affects hemodynami...

    Authors: Shunsuke Inage, Ryo Yajima, Shintaro Nagahara, Aya Kazama, Moe Takamura, Tomohiro Shoji, Mika Kadoi, Yukiko Tashiro and Yuya Ise
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:13
  18. Potentially inappropriate medications (PIMs) and polypharmacy in older adults lead to increase the risk of adverse drug events. This study aimed to evaluate the effectiveness of pharmacist intervention combini...

    Authors: Takeshi Kimura, Misa Fujita, Michiko Shimizu, Kasumi Sumiyoshi, Saho Bansho, Kazuhiro Yamamoto, Tomohiro Omura and Ikuko Yano
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:12
  19. Postoperative nausea and vomiting (PONV) delays postoperative recovery, prolongs hospital stays, and hinders patients’ return to society, thus making it a major cause of increased healthcare costs. It is also ...

    Authors: Satoshi Nagase, Masaharu Imaura, Mizuki Nishimura, Kohei Takeda, Mari Takahashi, Hideki Taniguchi, Tomoyuki Sato and Hiroshi Kanno
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:11
  20. A high prevalence of mental disorders including depression, anxiety, somatoform, and dissociative disorder is reported during pregnancy, however, information on the transfer of antipsychotics across the placen...

    Authors: Jumpei Saito, Yoshiyuki Tachibana, Yuka Sano Wada, Naho Yakuwa, Hiroyo Kawasaki, Tomo Suzuki, Haruhiko Sago, Akimasa Yamatani and Atsuko Murashima
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:10
  21. We report a case of delayed excretion of methotrexate (MTX) in a pediatric patient on high-dose MTX therapy in response to a change in the concomitant dosage of voriconazole from oral to intravenous. As the in...

    Authors: Daisuke Watahiki, Daisuke Saito, Naonori Nishida, Hiroyuki Tsuri, Keiko Nomura, Yuichi Adachi and Masato Taguchi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:9
  22. The effect of pharmaceutical intervention to treat adverse events on quality of life (QOL) in outpatients receiving cancer chemotherapy is unclear. We investigated whether pharmaceutical intervention provided ...

    Authors: Hironori Fujii, Yukino Ueda, Chiemi Hirose, Koichi Ohata, Kumiko Sekiya, Mika Kitahora, Shiori Sadaka, Senri Yamamoto, Daichi Watanabe, Hiroko Kato-Hayashi, Hirotoshi Iihara, Ryo Kobayashi, Miho Kaburaki, Nobuhisa Matsuhashi, Takao Takahashi, Akitaka Makiyama…
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:8
  23. Pharmacists guide patients in their use of traditional, complementary, and integrative medicine (TCIM). The present study aimed to evaluate the opinions of Japanese pharmacists regarding TCIM, and to evaluate ...

    Authors: Yoshiharu Motoo, Keiko Yukawa, Kazuho Hisamura and Ichiro Arai
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:7
  24. Voriconazole (VRCZ) is the first-line therapy for chronic pulmonary aspergillosis and is available in both intravenous and oral formulations. The bioavailability of the oral form is estimated to be over 90% in...

    Authors: Hiromi Kaneko, Shingo Yamazaki, Masashi Uchida, Takaaki Suzuki, Kentaro Murakami, Hisahiro Matsubara, Katsuhiko Kamei and Itsuko Ishii
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:6
  25. Gemcitabine plus nab-paclitaxel (GnP) therapy is used for unresectable pancreatic ductal adenocarcinoma, but may cause interstitial lung disease (ILD) as a serious side effect. However, the risk factors for IL...

    Authors: Rikako Ueda, Naho Yamamoto, Yuki Hori, Kouji Yoshida, Koushiro Ohtsubo, Takeshi Terashima, Tsutomu Shimada and Yoshimichi Sai
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:5
  26. The blood concentration of cyclosporine (CyA) is frequently elevated following the transfusion of red blood cell concentrate (RCC) to patients after allogeneic hematopoietic stem cell transplantation (HSCT). T...

    Authors: Masashi Uchida, Natsumi Hanada, Shingo Yamazaki, Hirokazu Takatsuka, Chiaki Imai, Akari Utsumi, Yuki Shiko, Yohei Kawasaki, Takaaki Suzuki and Itsuko Ishii
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:4
  27. The standard dose of vancomycin (VCM, 2 g/day) sometimes fails to achieve therapeutic concentration in patients with normal renal function. In this study, we aimed to identify factors to predict patients who r...

    Authors: Ryo Yamaguchi, Hiroko Kani, Takehito Yamamoto, Takehiro Tanaka and Hiroshi Suzuki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:3
  28. Tracheal intubation may be performed in patients with drug overdose due to self-harm; however, the details of the causative drug are unknown. The purpose of this study was to clarify the relationship between d...

    Authors: Kazuki Nagashima, Hiroyuki Hosono and Machiko Watanabe
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:2
  29. Casirivimab-imdevimab has been developed to neutralize SARS-CoV-2. The global clinical trials in outpatients documented several adverse effects (AE), which mandate caution in Japan where part of patients retur...

    Authors: Junichi Yoshida, Kenichiro Shiraishi, Tetsuro Tamura, Kazuhiro Otani, Tetsuya Kikuchi, Akiko Mataga, Takako Ueno and Masao Tanaka
    Citation: Journal of Pharmaceutical Health Care and Sciences 2022 8:1
  30. Clinical pharmacists play a role in limiting the disadvantages of pharmacotherapy for patients by detecting and resolving drug-related problems (DRPs) through medication reviews. Although their contributions t...

    Authors: Toshiya Oki, Sachi Ishii, Koya Furukawa, Aiko Shono and Manabu Akazawa
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:47
  31. Human immune deficiency virus (HIV) increases the susceptibility to primary infection or reinfection and the risk of tuberculosis (TB) reactivation for patients with latent TB. There was no current report on t...

    Authors: Temesgen Mulugeta, Alazar Takale, Belachew Umeta and Behailu Terefe
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:44
  32. Zinc is an essential trace element involved in various physiological functions. In Japan, zinc acetate dihydrate is administered to neonates and infants with hypozincemia. Since serum copper concentrations are...

    Authors: Toshikazu Ito, Kazuya Uenoyama, Kazuhiro Kobayashi, Mikio Kakumoto, Hiroshi Mizumoto, Toshiya Katsura and Masahide Onoue
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:46
  33. Although clozapine is the optimal drug for patients with treatment-resistant schizophrenia, the drug has harmful adverse effects such as leukopenia. Adenine and cepharanthine are known to be effective for radi...

    Authors: Shintaro Kamei, Ryota Tanaka, Hirofumi Hirakawa, Motoshi Iwao, Rikako Kawanaka, Ryosuke Tatsuta, Takeshi Terao and Hiroki Itoh
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:45
  34. Azelnidipine, a dihydropyridine calcium channel blocker (CCB), has less adverse effects (e.g. hot flushes and reflex tachycardia) compared to other dihydropyridine CCBs. Azelnidipine has been reported to reduc...

    Authors: Naohito Ide, Ayaka Mochizuki, Yoshiyuki Kagawa and Masaharu Ito
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:48
  35. Potential drug–drug interactions (PDDIs) commonly occur because of aging and comorbidities in people living with human immunodeficiency virus (HIV; PLWH). Protease inhibitors and non-nucleoside reverse transcr...

    Authors: Yusuke Kunimoto, Ryosuke Matamura, Hiroshi Ikeda, Satoshi Fujii, Tomoko Kimyo, Manabu Kitagawa, Hiromasa Nakata, Masayoshi Kobune, Atsushi Miyamoto and Masahide Fukudo
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:43
  36. Meningitis is a common infectious cause of morbidity and mortality in pediatric age-groups. Acute bacterial meningitis is considered a medical emergency, because it is a life-threatening infection that require...

    Authors: Firomsa Bekele, Anuwar Ahmed, Abas Kedir and Tadesse Sheleme
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:41
  37. Chronic Obstructive Pulmonary Disease (COPD) is one of the prominent cause of mortality worldwide. Nowadays, the level of medication adherence in COPD patients is very low, which reduces the clinical therapeut...

    Authors: Boyuk Moradkhani, Samaneh Mollazadeh, Parastoo Niloofar, Afsaneh Bashiri and Mohammad Bagher Oghazian
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:40
  38. Therapeutic drug monitoring for voriconazole is recommended for its optimum pharmacotherapy. Although the feedback of the measurement result of serum voriconazole concentration by outsourcing needs a certain t...

    Authors: Kazutaka Oda, Shota Uchino, Kayo Kurogi, Mai Horikawa, Naoya Matsumoto, Kou Yonemaru, Hitomi Arakaki, Taiki Katsume, Kaho Matsuyama, Tomomi Katanoda, Yuki Narita, Koji Iwamura, Hirofumi Jono and Hideyuki Saito
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:42
  39. Bucolome is a non-steroidal anti-inflammatory drug and uricosuric agent, currently used only in Japan. It is known to induce drug interactions by inhibiting cytochrome P450 (CYP) 2C9. It is often used to enhan...

    Authors: Hiroki Tateishi, Daisuke Miyazu, Miho Kurinami, Ichiro Ieiri, Masaaki Hirakawa and Hiroyuki Watanabe
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:39
  40. Pharmacist plays an integral role in promoting antimicrobial stewardship (AS) strategies by committing to the evidence-based activities in this field. The present study aims to document trends in actual achiev...

    Authors: Masayuki Maeda, Takefumi Miyake, Ryo Inose, Satoru Ueda, Ken-ichi Matsugi, Yuichi Muraki and Takashi Kitahara
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:38
  41. Keeping the heart rate within the normal range has improved the survival of septic shock patients. Amiodarone could target the underlying pathophysiology of sepsis-induced tachycardia. This study aimed to dete...

    Authors: Masoud Khataminia, Farhad Najmeddin, Atabak Najafi, Hamidreza Sharifnia, Arezoo Ahmadi, Adeleh Sahebnasagh and Mojtaba Mojtahedzadeh
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:37
  42. Caffeine (0.1 g) is used as a central nervous system stimulant and as a nontoxic phenotyping probe for cytochrome P450 1A2. However, an increasing number of suicide attempts by caffeine overdose have been rece...

    Authors: Koichiro Adachi, Satoru Beppu, Mariko Terashima, Toshiaki Fukuda, Jun Tomizawa, Makiko Shimizu and Hiroshi Yamazaki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:36
  43. Clinical management of skin-toxicity associated with the use of anti-Epidermal Growth Factor Receptor (EGFR) antibodies to treat colorectal cancer maintains quality of life of patients with colorectal cancer. ...

    Authors: Munenobu Kashiwa and Ryo Matsushita
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:35
  44. Drug overdose accounts for most of the admissions to the emergency department. Prescription drugs, most of which are psychotropic medications, are often misused for drug overdose. The purpose of this study was...

    Authors: Kazuki Nagashima, Megumi Sumida, Shoichi Imanaka, Tatsuro Kuwabara, Ichiro Kaneko, Yasufumi Miyake, Nobuhiro Yasuno, Fumio Itagaki and Machiko Watanabe
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:34
  45. Loxoprofen is a propionic acid derivative and is the most widely prescribed non-steroidal anti-inflammatory drug in Japan. Loxoprofen is generally considered to be relatively nontoxic.

    Authors: Koichiro Adachi, Yuki Sugitani, Ryo Unita, Kosuke Yoshida, Satoru Beppu, Mariko Terashima, Masaya Fujii, Makiko Shimizu and Hiroshi Yamazaki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:33
  46. Clonidine hydrochloride is used to treat sedative agent withdrawals, malignant hypertension, and anesthesia complications. Clonidine is also prescribed off-label to pediatric patients at a dose of 1 μg/kg. The...

    Authors: Jumpei Saito, Takehisa Hanawa, Takahiro Matsumoto, Nozomi Yoshikawa, Tsutomu Harada, Kana Iwahashi, Hidefumi Nakamura and Akimasa Yamatani
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:31
  47. Anticholinergic burden potentially increases the risk of fracture. Although there are various anticholinergic burden scales, little is known about the inter-scale compatibility regarding the relationship of an...

    Authors: Yukari Ogawa, Toshinori Hirai and Kiyoshi Mihara
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:30
  48. The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is the most frequent cause of hyponatremia in patients with cerebrovascular disease, and is often treated with oral salt tablets. However...

    Authors: Miyuki Takemura, Yuki Tanaka, Katsuhisa Inoue, Ikumi Tamai and Yoshiyuki Shirasaka
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:29
  49. Although the over-the-counter H1 receptor antagonist diphenhydramine is not a common drug of abuse, it was recently recognized as one of the substances causing acute poisoning in patients attempting suicide that ...

    Authors: Koichiro Adachi, Satoru Beppu, Mariko Terashima, Wataru Kobari, Makiko Shimizu and Hiroshi Yamazaki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:32
  50. Cancer chemotherapy usually improves clinical outcomes in patients with advanced pancreatic cancer (APC), but can also cause moderate-to-severe adverse events (AEs). We investigated the relationship between mo...

    Authors: Hironori Fujii, Maaya Koda, Shiori Sadaka, Koichi Ohata, Hiroko Kato-Hayashi, Hirotoshi Iihara, Ryo Kobayashi, Takuma Ishihara, Shinya Uemura, Takuji Iwashita, Hideki Hayashi, Tadashi Sugiyama, Masahito Shimizu and Akio Suzuki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:27

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