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  1. Few systematic reviews have examined the effects of sodium-glucose co-transporter 2 inhibitors (SGLT2is) on lipid profiles in Asian patients with type 2 diabetes mellitus. We conducted a systematic review with...

    Authors: Junichi Mukai, Ayano Yoshiyama and Rie Kubota
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:4
  2. Because cisplatin (CDDP) decreases upon light exposure, it is necessary to prevent such exposure during administration. However, the shielding conditions employed are not uniform. Therefore, in this study, we ...

    Authors: Tomoya Abe, Daigo Matsumoto, Toshiaki Nakayama, Yukinari Shimazaki, Atsunobu Sagara, Dan Kanehira, Takuya Azechi, Fumiaki Sato, Hiroyasu Sakai, Tetsuro Yumoto and Junzo Kamei
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:3
  3. Inappropriate dosing of direct oral anticoagulants (DOACs) has been associated with clinical safety and efficacy; however, little is known about clinical data associated with an inappropriate DOAC dosing in Ja...

    Authors: Motoyasu Miyazaki, Koichi Matsuo, Masanobu Uchiyama, Yoshihiko Nakamura, Yuya Sakamoto, Momoko Misaki, Kaoko Tokura, Shiro Jimi, Keisuke Okamura, Sen Adachi, Tomohiko Yamamoto, Kazuyuki Shirai, Hidenori Urata and Osamu Imakyure
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:2
  4. The clobetasol propionate cream formulations (CLBCr) belong to the “strongest” group, and are used widely. In addition, those formulations are often used as a mixture with moisturizer. Recently, we evaluated phar...

    Authors: Yoshihisa Yamamoto, Yoshinori Onuki, Toshiro Fukami and Tatsuo Koide
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:1
  5. Sipuleucel-T, an autologous active cellular immunotherapy, is indicated for the treatment of asymptomatic or minimally symptomatic castration-resistant prostate cancer. The U.S. Food and Drug Administration Ad...

    Authors: Graça M. Dores, Silvia Perez-Vilar and Manette T. Niu
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:27
  6. Atropine eye drops are indicated for juvenile myopia progression, cycloplegia, amblyopia, and strabismus. According to the package insert, 10 mg/mL atropine eye drops must be diluted for pediatric patients to ...

    Authors: Jumpei Saito, Hitomi Imaizumi and Akimasa Yamatani
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:25
  7. Food is known to affect drug absorption by delaying gastric emptying time, altering gastrointestinal pH, stimulating bile flow, increasing splanchnic blood flow, or physically interacting with drugs. Although ...

    Authors: Fukiko Omachi, Masaki Kaneko, Ryosuke Iijima, Machiko Watanabe and Fumio Itagaki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:26
  8. Cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) regimen includes a high dose of prednisolone (100 mg/body), which exhibits an anticancer and antiemetic effect. However, its optimal use for ...

    Authors: Yoshinori Wakasugi, Satoshi Noda, Yoshihiro Ikuno, Miya Horie, Katsuyuki Kito, Hitoshi Minamiguchi and Tomohiro Terada
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:24
  9. Both polypharmacy and frailty are critical issues faced by the elderly. The decrease in gait speed is an index of frailty, and it is generally associated with falls and fractures, which are risk factors requir...

    Authors: Masataka Deguchi, Keigo Nishida, Tomoyuki Enokiya and Kazuya Ooi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:23
  10. Multiple daily subcutaneous injections (MDSIs) are mainly used for formulating an insulin therapy for diabetic patients; however, they also cause insulin-derived amyloidosis (IDA) and lead to poor glycemic con...

    Authors: Yui Ohno, Tomohiro Seki, Yu Kojima, Ryotaro Miki, Yuya Egawa, Osamu Hosoya, Keizo Kasono and Toshinobu Seki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:22
  11. Infliximab (IFX) has changed the management of many life-threatening immune-mediated diseases. The high cost of IFX and its patent expiry have led to pharmaceutical companies developing a biosimilar; however, ...

    Authors: Iku Niinomi, Keiko Hosohata, Yasuhiro Mori, Yuki Yamaguchi, Tomohito Wakabayashi, Mayako Uchida and Kazunori Iwanaga
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:21
  12. There is a lack of evidence that multidrug use triggers adverse events. Therefore, the main purpose of this study was to clarify the relationship between the total number of drugs and number of high-risk presc...

    Authors: Sayaka Arai, Takahiro Ishikawa, Hisaya Kato, Masaya Koshizaka, Yoshio Maezawa, Takako Nakamura, Takaaki Suzuki, Koutaro Yokote and Itsuko Ishii
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:20
  13. Chemotherapy is important for cancer treatment, but patients’ physical and mental stress may lead to unfavorable pain control, an increase in the risk of relapse, and a reduction in the quality of life (QOL). ...

    Authors: Chiaki Takagi, Saori Nakagawa, Naoto Hirata, Shin Ohta and Sadahiko Shimoeda
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:18
  14. According to the Clinical Practice Guidelines for Clostridioides difficile, oral vancomycin is to be used in vancomycin tapered and pulsed regimen (VCM-TP) for recurrent Clostridium difficile infection (CDI). How...

    Authors: Takumi Umemura, Aiko Ota, Yoshikazu Mutoh, Chihiro Norizuki, Takahito Mizuno, Koji Kozaki, Yoshiaki Ikeda and Toshihiko Ichihara
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:19
  15. Dabigatran is a direct thrombin inhibitor and an anticoagulant that is prescribed to prevent ischemic stroke and systemic embolism in non-valvular atrial fibrillation. Dabigatran (150 mg twice daily) is non-in...

    Authors: Yuuki Akagi, Tatsuo Chiba, Shusuke Uekusa, Hiroyoshi Kato, Shigeo Yamamura, Yukiko Aoki, Mizuho Enoki, Yuka Ogawara, Takanori Kasahara, Yuki Kimura, Tadahiro Shimizu, Aiko Takeishi, Yuko Nakajima, Hideki Kobayashi and Kaoru Sugi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:17
  16. Oral mucositis is a frequent and severe adverse event in patients undergoing chemoradiotherapy for head and neck cancers, especially grade 3 or 4 mucositis. Occurrence may result in drop-out from treatment, th...

    Authors: Shinsuke Akagi, Takashi Fujiwara, Mai Nishida, Akiko Okuda, Yuka Nagao, Toshikatsu Okuda, Hidenori Tokuda and Kazunobu Takayanagi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:16
  17. Despite the high mortality of patients with sepsis and carbapenem-resistant bacteria infection, appropriate antimicrobial therapies are yet to be established. Here, we have reported the case of a patient with ...

    Authors: Kazutaka Oda, Hidenobu Kamohara, Tomomi Katanoda, Yumi Hashiguchi, Koji Iwamura, Kisato Nosaka, Hirofumi Jono and Hideyuki Saito
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:15
  18. There is no nationwide data on polypharmacy in palliative care in Japan. In this study, the research committee of the Japanese Society for Pharmaceutical Palliative Care and Sciences conducted an online survey...

    Authors: Mayako Uchida, Shinya Suzuki, Hideki Sugawara, Yukio Suga, Hideya Kokubun, Yoshihiro Uesawa, Takayuki Nakagawa and Hisamitsu Takase
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:14
  19. Piperacillin/tazobactam (PIPC/TAZ) and cefepime (CFPM) are commonly used for the treatment of nosocomial and healthcare-associated infections. Recent reports have suggested that the incidence of acute kidney i...

    Authors: Shota Kadomura, Yoh Takekuma, Yuki Sato, Masato Sumi, Kotaro Kawamoto, Tatsuya Itoh and Mitsuru Sugawara
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:13
  20. Tenofovir disoproxil fumarate (TDF) is known to reduce estimated glomerular filtration rate (eGFR). It is clinically important to identify patients at high risk for renal dysfunction as early as possible. Amon...

    Authors: Shinichi Hikasa, Shota Shimabukuro, Kyoko Hideta, Satoshi Higasa, Akihiro Sawada, Tazuko Tokugawa, Kuniyoshi Tanaka, Mina Yanai and Takeshi Kimura
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:12
  21. To facilitate timely removal of urinary catheters and promote self-voiding among inpatients, urinary care teams have been established in some Japanese medical institutions. However, direct evidence of the effe...

    Authors: Takumi Umemura, Eri Wakita, Masami Asano, Takahito Mizuno, Koji Kozaki, Yoshiaki Ikeda and Hirokazu Takeda
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:11
  22. Vancomycin is commonly used to treat Enterococcus faecium (E. faecium) bacteremia. However, there are very few studies on the association between the trough concentration, area under the curve from 0 to 24 h /min...

    Authors: Ichiro Nakakura, Kota Sakakura, Kaori Imanishi, Rumi Sako and Kunio Yamazaki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:8
  23. Hepatectomy is a highly invasive procedure with a high probability of postoperative delirium. Treatment with antiulcer drugs is indispensable after hepatectomy for anastomotic ulcer management. The clinical pa...

    Authors: Miho Yamasaki, Yusa Fukuda, Aika Tanimoto, Miko Narahara, Yumi Kawaguchi, Hiromi Ushiroda, Saburo Fukuda, Teruo Murakami and Yorinobu Maeda
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:10
  24. Infliximab (IFX), a mouse-human chimeric monoclonal antibody against human tumor necrosis factor alpha, is used in refractory cases of Takayasu arteritis. Several factors influence the pharmacokinetics of ther...

    Authors: Sho Masui, Atsushi Yonezawa, Kazushi Izawa, Makoto Hayakari, Kayoko Asakura, Risa Taniguchi, Masahiko Isa, Hirofumi Shibata, Takahiro Yasumi, Ryuta Nishikomori, Junko Takita and Kazuo Matsubara
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:9
  25. Ritodrine hydrochloride (RD), a β2-adrenergic agonist, is widely used as a tocolytic medication to suppress premature labor, but can cause neonatal hypoglycemia, a potentially severe side effect. We examined t...

    Authors: Shoko Shimokawa, Akiko Sakata, Yukio Suga, Kazuya Isoda, Shingo Itai, Katsuhiko Nagase, Tsutomu Shimada and Yoshimichi Sai
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:7
  26. Everolimus is an oral inhibitor of mammalian target of rapamycin, approved for metastatic renal cell carcinoma (mRCC). Recently, personalized medicine through therapeutic drug monitoring (TDM) is recommended i...

    Authors: Shinya Takasaki, Hiroaki Yamaguchi, Yoshihide Kawasaki, Masafumi Kikuchi, Masaki Tanaka, Akihiro Ito and Nariyasu Mano
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:6
  27. There have been debates about the association between the administration of glucocorticoids and the development of acute pancreatitis, since many anecdotal cases of this adverse event were affected either by c...

    Authors: Daisuke Nango, Yukifumi Hirose, Makoto Goto and Hirotoshi Echizen
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:5
  28. Magnesium oxide (MgO), an antacid and laxative, is widely used in Japan to treat constipation and peptic ulcers. Because serum Magnesium (Mg) levels are elevated in elderly and/or patients with renal failure, ...

    Authors: Eri Wakai, Kenji Ikemura, Hiroko Sugimoto, Takuya Iwamoto and Masahiro Okuda
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:4
  29. Medical staff should promptly administer antimicrobials to patients with febrile neutropenia (FN) to decrease the mortality related to cancer chemotherapy. Corticosteroids, which are used in cancer chemotherap...

    Authors: Hiroki Uda, Yukio Suga, Eriko Toriba, Angelina Yukiko Staub, Tsutomu Shimada, Yoshimichi Sai, Masami Kawahara and Ryo Matsusita
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:3
  30. The self-management of type 2 diabetes mellitus (T2DM), which involves adherence to medical instructions on diet and nutritional advice, physical activity, medication regimen, and weight and stress management,...

    Authors: Kana Hashimoto, Koki Urata, Ayano Yoshida, Reiko Horiuchi, Naoto Yamaaki, Kunimasa Yagi and Kunizo Arai
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:2
  31. Medication therapy management (MTM) service provides set of clinical activities to optimize therapeutic outcomes for patients. It requires the collaboration between patient, pharmacist and other healthcare pro...

    Authors: Noor Kifah Al-Tameemi and Azmi Sarriff
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:1
  32. Falls are a common but serious problem in older adults, and may lead to fractures and bleeding. As many factors, such as medication, aging, and comorbid diseases may simultaneously affect fall-related adverse ...

    Authors: Haruna Hatahira, Shiori Hasegawa, Sayaka Sasaoka, Yamato Kato, Junko Abe, Yumi Motooka, Akiho Fukuda, Misa Naganuma, Satoshi Nakao, Ririka Mukai, Kazuyo Shimada, Kouseki Hirade, Takeshi Kato and Mitsuhiro Nakamura
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:32
  33. Pharmaceutical intervention enables safe and effective pharmacotherapy by avoiding of adverse drug reactions (ADRs) and efficacy attenuations. Many prescriptions require optimization, and pharmaceutical interv...

    Authors: Yuichi Tasaka, Akihiro Tanaka, Daiki Yasunaga, Takashige Asakawa, Hiroaki Araki and Mamoru Tanaka
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:33
  34. We conducted an economic assessment using test data from the phase III TRIPLE study, which examined the efficacy of a 5-hydroxytryptamine 3 receptor antagonist as part of a standard triplet antiemetic regimen ...

    Authors: Hisanori Shimizu, Kenichi Suzuki, Takeshi Uchikura, Daiki Tsuji, Takeharu Yamanaka, Hironobu Hashimoto, Koichi Goto, Reiko Matsui, Nobuhiko Seki, Toshikazu Shimada, Shunya Ikeda, Naoki Ikegami, Toshihiro Hama, Nobuyuki Yamamoto and Tadanori Sasaki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:31
  35. S-1 (a combination of tegafur, gimeracil, and oteracil) is used to treat various cancers. Bone marrow suppression is a dose-limiting toxicity of S-1. The relationship between relative dose intensity (RDI) and ...

    Authors: Toshinori Hirai, Ryuichi Ogawa, Ryosuke Yamaga and Toshimasa Itoh
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:30
  36. To our knowledge, no studies have evaluated the safety of carboplatin (CBDCA)-based chemotherapy in hemodialysis patients > 80 years-old. In addition, the impact of CBDCA-based chemotherapy on such elderly pat...

    Authors: Masahiro Kondo, Taku Naiki, Yuji Hotta, Yuko Yamamoto, Yosuke Sugiyama, Takahiro Yasui and Kazunori Kimura
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:29
  37. Risperidone is mainly metabolized by cytochrome P450 (CYP) 2D6 in the liver. The gene encoding CYP2D6 is highly polymorphic. The average steady-state plasma concentration of risperidone active moiety is higher in...

    Authors: Takahiro Ito, Kazuhiro Yamamoto, Fuminori Ohsawa, Ikuo Otsuka, Akitoyo Hishimoto, Ichiro Sora, Midori Hirai and Ikuko Yano
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:28
  38. Combination therapy of linezolid (LZD) and rifampicin (RFP) may be more effective than monotherapy for treating gram-positive bacterial infections, but several studies have suggested that RFP decreases LZD exp...

    Authors: Satsuki Hashimoto, Kyoko Honda, Kohei Fujita, Yuka Miyachi, Kazuya Isoda, Ko Misaka, Yukio Suga, Satoshi Kato, Hiroyuki Tsuchiya, Yukio Kato, Masaki Okajima, Takumi Taniguchi, Tsutomu Shimada and Yoshimichi Sai
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:27
  39. Vinorelbine is known to be effective in the treatment of non-small cell lung cancer and breast cancer. However, venous irritation is a common side effect. Although there have been some reports on risk factors ...

    Authors: Yoshihito Morimoto, Kumika Miyawaki, Reisuke Seki, Kazuhiro Watanabe, Masayoshi Hirohara and Takao Shinohara
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:26
  40. Appropriate prophylactic rescue dosing of opioids is considered effective for cancer pain relief, but no study has reported the safety of such prophylactic rescue. We compared the safety of prophylactic rescue...

    Authors: Rei Tanaka, Hiroshi Ishikawa, Tetsu Sato, Michihiro Shino, Katsuhiro Omae, Tetsumi Sato and Iwao Osaka
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:25
  41. The utility and effectiveness of inhalational asthma therapy in patients with a permanent tracheostomy has not been established. Previously, a few studies reported the use of nebulizer-type inhalers for treati...

    Authors: Kohhei Maeda, Masao Yamaguchi, Hiroyuki Nagase, Nobuhiro Yasuno, Fumio Itagaki and Machiko Watanabe
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:24
  42. It is well known that low-dose, long-term macrolide therapy is effective against chronic inflammatory airway diseases. Oxidative stress is considered to be a key pathogenesis factor in those diseases. However,...

    Authors: Kuninori Iwayama, Junpei Kimura, Aya Mishima, Ayuko Kusakabe, Ko-ichi Ohtaki, Yoshiko Tampo and Nobumasa Hayase
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:23
  43. Since both the antibacterial effects and common adverse effects of colistin are concentration-dependent, determination of the most appropriate dosage regimen and administration method for colistin therapy is e...

    Authors: Yuki Hanai, Kazuhiro Matsuo, Takayoshi Kosugi, Ayumu Kusano, Hayato Ohashi, Itsuki Kimura, Shinobu Hirayama, Yuta Nanjo, Yoshikazu Ishii, Takahiro Sato, Taito Miyazaki, Kenji Nishizawa and Takashi Yoshio
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:22
  44. The efficacy of sodium azulene sulfonate L-glutamine (GA) in treating oral mucositis caused by the administration of anticancer agents has not been previously elucidated. Therefore, this prospective comparativ...

    Authors: Satoru Nihei, Junya Sato, Hideaki Komatsu, Kazushige Ishida, Toshimoto Kimura, Takashi Tomita and Kenzo Kudo
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:20
  45. Vascular pain is a common adverse drug reaction in colorectal cancer patients receiving peripheral venous administration of oxaliplatin. The aim of this work was to identify risk factors for vascular pain, and...

    Authors: Yukio Suga, Nana Ikeda, Manami Maeda, Angelina Yukiko Staub, Tsutomu Shimada, Miwa Yonezawa, Hironori Kitade, Hideyuki Katsura, Morihiro Okada, Junko Ishizaki, Yoshimichi Sai and Ryo Matsushita
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:18
  46. Colloidal saccharated iron oxide injection is used for the treatment of iron deficiency anemia in patients with a poor oral intake. Because of the poor stability of the colloid particle, there have been concer...

    Authors: Daiki Hira, Asami Suzuki, Yusuke Kono, Kosuke Shimokawa, Serika Matsuoka, Ken-yuh Hasumoto, Hiroyuki Kawahara, Masahide Onoue, Takuya Fujita, Tomonobu Okano and Mikio Kakumoto
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:21
  47. Direct-acting antivirals (DAAs) are known to improve tolerability and have higher efficacy and shorter treatment durations compared with conventional interferon (IFN)-based treatments for hepatitis C virus (HC...

    Authors: Haruna Yamamoto, Hiroaki Ikesue, Mai Ikemura, Rieko Miura, Kazumi Fujita, Hobyung Chung, Yoshiki Suginoshita, Tetsuro Inokuma and Tohru Hashida
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:17
  48. Clinical cases are often observed when patients are in need of repeated use of analgesic infusion to manage pain after colon cancer surgery. This paper investigates analgesic frequency as well as safety of pos...

    Authors: Eiji Horita, Yuji Takahashi, Kojiro Takashima, Kenichiro Saito, Yoshihiro Takashima and Yoshinori Munemoto
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:19
  49. Insufficient medication adherence in diabetes patients, of which numbers continue to increase globally, remains a critical issue. Medication adherence is multifactorial and determined by interactions among fac...

    Authors: Yoshiko Tominaga, Tohru Aomori, Tomohisa Hayakawa, Nobuhiko Kijima, Donald E. Morisky, Kunihiko Takahashi and Mayumi Mochizuki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:16
  50. Incretin-based drugs are important in the treatment of type 2 diabetes. However, among the incretin-based drugs, glucagon-like peptide-1 receptor agonists (GLP-1-RAs) have been reported to cause gastroesophage...

    Authors: Yoshihiro Noguchi, Hayato Katsuno, Anri Ueno, Manami Otsubo, Aki Yoshida, Yuta Kanematsu, Ikuto Sugita, Hiroki Esaki, Tomoya Tachi, Teruo Tsuchiya and Hitomi Teramachi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:15

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