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  1. Ritodrine hydrochloride (RD), a β2-adrenergic agonist, is widely used as a tocolytic medication to suppress premature labor, but can cause neonatal hypoglycemia, a potentially severe side effect. We examined t...

    Authors: Shoko Shimokawa, Akiko Sakata, Yukio Suga, Kazuya Isoda, Shingo Itai, Katsuhiko Nagase, Tsutomu Shimada and Yoshimichi Sai
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:7
  2. Everolimus is an oral inhibitor of mammalian target of rapamycin, approved for metastatic renal cell carcinoma (mRCC). Recently, personalized medicine through therapeutic drug monitoring (TDM) is recommended i...

    Authors: Shinya Takasaki, Hiroaki Yamaguchi, Yoshihide Kawasaki, Masafumi Kikuchi, Masaki Tanaka, Akihiro Ito and Nariyasu Mano
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:6
  3. There have been debates about the association between the administration of glucocorticoids and the development of acute pancreatitis, since many anecdotal cases of this adverse event were affected either by c...

    Authors: Daisuke Nango, Yukifumi Hirose, Makoto Goto and Hirotoshi Echizen
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:5
  4. Magnesium oxide (MgO), an antacid and laxative, is widely used in Japan to treat constipation and peptic ulcers. Because serum Magnesium (Mg) levels are elevated in elderly and/or patients with renal failure, ...

    Authors: Eri Wakai, Kenji Ikemura, Hiroko Sugimoto, Takuya Iwamoto and Masahiro Okuda
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:4
  5. Medical staff should promptly administer antimicrobials to patients with febrile neutropenia (FN) to decrease the mortality related to cancer chemotherapy. Corticosteroids, which are used in cancer chemotherap...

    Authors: Hiroki Uda, Yukio Suga, Eriko Toriba, Angelina Yukiko Staub, Tsutomu Shimada, Yoshimichi Sai, Masami Kawahara and Ryo Matsusita
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:3
  6. The self-management of type 2 diabetes mellitus (T2DM), which involves adherence to medical instructions on diet and nutritional advice, physical activity, medication regimen, and weight and stress management,...

    Authors: Kana Hashimoto, Koki Urata, Ayano Yoshida, Reiko Horiuchi, Naoto Yamaaki, Kunimasa Yagi and Kunizo Arai
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:2
  7. Medication therapy management (MTM) service provides set of clinical activities to optimize therapeutic outcomes for patients. It requires the collaboration between patient, pharmacist and other healthcare pro...

    Authors: Noor Kifah Al-Tameemi and Azmi Sarriff
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:1
  8. Falls are a common but serious problem in older adults, and may lead to fractures and bleeding. As many factors, such as medication, aging, and comorbid diseases may simultaneously affect fall-related adverse ...

    Authors: Haruna Hatahira, Shiori Hasegawa, Sayaka Sasaoka, Yamato Kato, Junko Abe, Yumi Motooka, Akiho Fukuda, Misa Naganuma, Satoshi Nakao, Ririka Mukai, Kazuyo Shimada, Kouseki Hirade, Takeshi Kato and Mitsuhiro Nakamura
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:32
  9. Pharmaceutical intervention enables safe and effective pharmacotherapy by avoiding of adverse drug reactions (ADRs) and efficacy attenuations. Many prescriptions require optimization, and pharmaceutical interv...

    Authors: Yuichi Tasaka, Akihiro Tanaka, Daiki Yasunaga, Takashige Asakawa, Hiroaki Araki and Mamoru Tanaka
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:33
  10. We conducted an economic assessment using test data from the phase III TRIPLE study, which examined the efficacy of a 5-hydroxytryptamine 3 receptor antagonist as part of a standard triplet antiemetic regimen ...

    Authors: Hisanori Shimizu, Kenichi Suzuki, Takeshi Uchikura, Daiki Tsuji, Takeharu Yamanaka, Hironobu Hashimoto, Koichi Goto, Reiko Matsui, Nobuhiko Seki, Toshikazu Shimada, Shunya Ikeda, Naoki Ikegami, Toshihiro Hama, Nobuyuki Yamamoto and Tadanori Sasaki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:31
  11. S-1 (a combination of tegafur, gimeracil, and oteracil) is used to treat various cancers. Bone marrow suppression is a dose-limiting toxicity of S-1. The relationship between relative dose intensity (RDI) and ...

    Authors: Toshinori Hirai, Ryuichi Ogawa, Ryosuke Yamaga and Toshimasa Itoh
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:30
  12. To our knowledge, no studies have evaluated the safety of carboplatin (CBDCA)-based chemotherapy in hemodialysis patients > 80 years-old. In addition, the impact of CBDCA-based chemotherapy on such elderly pat...

    Authors: Masahiro Kondo, Taku Naiki, Yuji Hotta, Yuko Yamamoto, Yosuke Sugiyama, Takahiro Yasui and Kazunori Kimura
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:29
  13. Risperidone is mainly metabolized by cytochrome P450 (CYP) 2D6 in the liver. The gene encoding CYP2D6 is highly polymorphic. The average steady-state plasma concentration of risperidone active moiety is higher in...

    Authors: Takahiro Ito, Kazuhiro Yamamoto, Fuminori Ohsawa, Ikuo Otsuka, Akitoyo Hishimoto, Ichiro Sora, Midori Hirai and Ikuko Yano
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:28
  14. Combination therapy of linezolid (LZD) and rifampicin (RFP) may be more effective than monotherapy for treating gram-positive bacterial infections, but several studies have suggested that RFP decreases LZD exp...

    Authors: Satsuki Hashimoto, Kyoko Honda, Kohei Fujita, Yuka Miyachi, Kazuya Isoda, Ko Misaka, Yukio Suga, Satoshi Kato, Hiroyuki Tsuchiya, Yukio Kato, Masaki Okajima, Takumi Taniguchi, Tsutomu Shimada and Yoshimichi Sai
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:27
  15. Vinorelbine is known to be effective in the treatment of non-small cell lung cancer and breast cancer. However, venous irritation is a common side effect. Although there have been some reports on risk factors ...

    Authors: Yoshihito Morimoto, Kumika Miyawaki, Reisuke Seki, Kazuhiro Watanabe, Masayoshi Hirohara and Takao Shinohara
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:26
  16. Appropriate prophylactic rescue dosing of opioids is considered effective for cancer pain relief, but no study has reported the safety of such prophylactic rescue. We compared the safety of prophylactic rescue...

    Authors: Rei Tanaka, Hiroshi Ishikawa, Tetsu Sato, Michihiro Shino, Katsuhiro Omae, Tetsumi Sato and Iwao Osaka
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:25
  17. The utility and effectiveness of inhalational asthma therapy in patients with a permanent tracheostomy has not been established. Previously, a few studies reported the use of nebulizer-type inhalers for treati...

    Authors: Kohhei Maeda, Masao Yamaguchi, Hiroyuki Nagase, Nobuhiro Yasuno, Fumio Itagaki and Machiko Watanabe
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:24
  18. It is well known that low-dose, long-term macrolide therapy is effective against chronic inflammatory airway diseases. Oxidative stress is considered to be a key pathogenesis factor in those diseases. However,...

    Authors: Kuninori Iwayama, Junpei Kimura, Aya Mishima, Ayuko Kusakabe, Ko-ichi Ohtaki, Yoshiko Tampo and Nobumasa Hayase
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:23
  19. Since both the antibacterial effects and common adverse effects of colistin are concentration-dependent, determination of the most appropriate dosage regimen and administration method for colistin therapy is e...

    Authors: Yuki Hanai, Kazuhiro Matsuo, Takayoshi Kosugi, Ayumu Kusano, Hayato Ohashi, Itsuki Kimura, Shinobu Hirayama, Yuta Nanjo, Yoshikazu Ishii, Takahiro Sato, Taito Miyazaki, Kenji Nishizawa and Takashi Yoshio
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:22
  20. The efficacy of sodium azulene sulfonate L-glutamine (GA) in treating oral mucositis caused by the administration of anticancer agents has not been previously elucidated. Therefore, this prospective comparativ...

    Authors: Satoru Nihei, Junya Sato, Hideaki Komatsu, Kazushige Ishida, Toshimoto Kimura, Takashi Tomita and Kenzo Kudo
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:20
  21. Vascular pain is a common adverse drug reaction in colorectal cancer patients receiving peripheral venous administration of oxaliplatin. The aim of this work was to identify risk factors for vascular pain, and...

    Authors: Yukio Suga, Nana Ikeda, Manami Maeda, Angelina Yukiko Staub, Tsutomu Shimada, Miwa Yonezawa, Hironori Kitade, Hideyuki Katsura, Morihiro Okada, Junko Ishizaki, Yoshimichi Sai and Ryo Matsushita
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:18
  22. Colloidal saccharated iron oxide injection is used for the treatment of iron deficiency anemia in patients with a poor oral intake. Because of the poor stability of the colloid particle, there have been concer...

    Authors: Daiki Hira, Asami Suzuki, Yusuke Kono, Kosuke Shimokawa, Serika Matsuoka, Ken-yuh Hasumoto, Hiroyuki Kawahara, Masahide Onoue, Takuya Fujita, Tomonobu Okano and Mikio Kakumoto
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:21
  23. Direct-acting antivirals (DAAs) are known to improve tolerability and have higher efficacy and shorter treatment durations compared with conventional interferon (IFN)-based treatments for hepatitis C virus (HC...

    Authors: Haruna Yamamoto, Hiroaki Ikesue, Mai Ikemura, Rieko Miura, Kazumi Fujita, Hobyung Chung, Yoshiki Suginoshita, Tetsuro Inokuma and Tohru Hashida
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:17
  24. Clinical cases are often observed when patients are in need of repeated use of analgesic infusion to manage pain after colon cancer surgery. This paper investigates analgesic frequency as well as safety of pos...

    Authors: Eiji Horita, Yuji Takahashi, Kojiro Takashima, Kenichiro Saito, Yoshihiro Takashima and Yoshinori Munemoto
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:19
  25. Insufficient medication adherence in diabetes patients, of which numbers continue to increase globally, remains a critical issue. Medication adherence is multifactorial and determined by interactions among fac...

    Authors: Yoshiko Tominaga, Tohru Aomori, Tomohisa Hayakawa, Nobuhiko Kijima, Donald E. Morisky, Kunihiko Takahashi and Mayumi Mochizuki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:16
  26. Incretin-based drugs are important in the treatment of type 2 diabetes. However, among the incretin-based drugs, glucagon-like peptide-1 receptor agonists (GLP-1-RAs) have been reported to cause gastroesophage...

    Authors: Yoshihiro Noguchi, Hayato Katsuno, Anri Ueno, Manami Otsubo, Aki Yoshida, Yuta Kanematsu, Ikuto Sugita, Hiroki Esaki, Tomoya Tachi, Teruo Tsuchiya and Hitomi Teramachi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:15
  27. In recent years, the popularity of LED lighting has rapidly increased, owing to its many advantages, including economic benefits. We examined the change in the quality of drugs during storage under LED and flu...

    Authors: Shuuji Yamashita, Kazuhiro Iguchi, Yoshihiro Noguchi, Chihiro Sakai, Satoshi Yokoyama, Yoko Ino, Hideki Hayashi, Hitomi Teramachi, Magoichi Sako and Tadashi Sugiyama
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:12
  28. A causal relationship between acute pancreatitis and administration of glucocorticoids remains a matter of debate, since most of the reported cases were diagnosed with systemic vascular diseases (including sys...

    Authors: Daisuke Nango, Hiroki Nakashima, Yukifumi Hirose, Masaaki Shiina and Hirotoshi Echizen
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:14
  29. Amiodarone and warfarin are sometimes administered immediately after cardiac surgery. Although the interaction between long-term oral amiodarone and warfarin has been reported, the interaction between warfarin...

    Authors: Tomoki Takase, Hiroaki Ikesue, Makiko Tohi, Hiroshi Ueta, Hiroyuki Mima, Tadaaki Koyama and Tohru Hashida
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:13
  30. Intestinal absorption of new quinolones is decreased by oral administration of polyvalent metal cations. Some clinical studies have demonstrated this drug - drug interaction is more prominent under fasted cond...

    Authors: Ayuko Imaoka, Kosuke Abiru, Takeshi Akiyoshi and Hisakazu Ohtani
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:11
  31. The contents of the guidelines for the use of non-benzodiazepines (Z-drugs) differ slightly between THE JAPANESE SOCIETY OF SLEEP RESEARCH and THE JAPAN GERIATRIC SOCIETY, and the recommended directions are co...

    Authors: Yoshihiro Noguchi, Anri Ueno, Hayato Katsuno, Manami Otsubo, Aki Yoshida, Yuta Kanematsu, Ikuto Sugita, Tomoya Tachi, Teruo Tsuchiya and Hitomi Teramachi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:10
  32. In recent years, cancer chemotherapy is being conducted at outpatient clinics, wherein pharmacists are involved with patient guidance and management of adverse events as experts in medication therapy. Therefor...

    Authors: Kazuhide Tanaka, Akiyo Hori, Tomoya Tachi, Tomohiro Osawa, Katsuhiro Nagaya, Teppei Makino, Seiji Inoue, Masahiro Yasuda, Takashi Mizui, Takumi Nakada, Chitoshi Goto and Hitomi Teramachi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:9
  33. Infusion sets designed for peristaltic finger smart pumps (PFSPs) are necessary for the pumps’ accurate handling. We previously found that medication dispensing is occasionally incomplete following the calcula...

    Authors: Masayuki Umemura, Kanae Maegawa, Daichi Arai, Katsuro Shigeno and Yoshifumi Wakiya
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:8
  34. Mycophenolic acid (MPA) treatment requires therapeutic drug monitoring to improve the outcome after organ transplantation. The aim of this study was to compare two methods, a particle enhanced turbidimetric in...

    Authors: Masafumi Kikuchi, Masaki Tanaka, Shinya Takasaki, Akiko Takahashi, Miki Akiba, Yasushi Matsuda, Masafumi Noda, Kanehiko Hisamichi, Hiroaki Yamaguchi, Yoshinori Okada and Nariyasu Mano
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:7
  35. Fluconazole is frequently prescribed for the treatment of systemic fungal infection in neonates and infants. At present, prediction of fluconazole doses according to developmental changes in fluconazole cleara...

    Authors: Kazutoshi Murakoso, Ryoichi Minagawa and Hirotoshi Echizen
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:5
  36. The objective of the current study is to elucidate the effect that the adoption of generic drugs by a large hospital has on the dispensation of generic drugs by community pharmacies. We evaluated the percentag...

    Authors: Tomoya Tachi, Kosuke Saito, Hiroki Esaki, Ikuto Sugita, Aki Yoshida, Yuta Kanematsu, Yoshihiro Noguchi, Michi Umeda, Masahiro Yasuda, Takashi Mizui, Teruo Tsuchiya, Chitoshi Goto and Hitomi Teramachi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:6
  37. Patients with Sjögren’s syndrome (SS) typically present clinically with xerostomia (dry mouth) because of progressive damage to the exocrine glands. We developed a new, low-dose pilocarpine/sodium alginate (LP...

    Authors: Machiko Watanabe, Chisato Yamada, Yoshinori Komagata, Hirotoshi Kikuchi, Hiroyuki Hosono and Fumio Itagaki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:4
  38. Most eye disorders are not fatal but may deteriorate the quality of life of a patient. The eye disorder that is most frequently reported in the cancer chemotherapy is associated with the combination of tegafur...

    Authors: Reiko Kuriki, Tsuyoshi Hata, Kinuyo Nakayama, Yuichi Ito, Kazunari Misawa, Seiji Ito, Michiko Tatematsu and Norio Kaneda
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:3
  39. Clinical practice guidelines should be user-friendly and confirming their penetration rate and compliance are critical.

    Authors: Tetsuya Sasaki, Yasuhisa Kato, Atsushi Sato, Noriko Usui, Eishi Baba, Toshimi Takano, Nobuyuki Susumu, Kazunori Ohnishi, Hitomi Nishimoto and Katsuyuki Kiura
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:2
  40. Antiemetic effects and safety of granisetron or palonosetron alone and in combination with a corticosteroid against chemotherapy-induced nausea and vomiting (CINV) were retrospectively evaluated in patients wi...

    Authors: Mayako Uchida, Tsutomu Nakamura, Kojiro Hata, Hiroyuki Watanabe, Yasuo Mori, Koji Kato, Kenjiro Kamezaki, Katsuto Takenaka, Motoaki Shiratsuchi, Keiko Hosohata, Toshihiro Miyamoto and Koichi Akashi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2018 4:1
  41. Treatment satisfaction and medication adherence can be improved if physicians carefully monitor the situations, check the level of difficulties patients experience when taking medications at specific times, an...

    Authors: Naoko Ogawa, Mitsuyoshi Takahara, Toshihiko Shiraiwa, Mayumi Yamamoto, Kaoru Yamamoto, Masayuki Doi, Yoko Yoshida and Setsuko Gotou
    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:27
  42. A dry powder inhaled formulation is used for the anti-influenza drug laninamivir octanoate hydrate (laninamivir). Although two successive inhalations (puffs) are recommended to minimize residual amounts of act...

    Authors: Toshiki Murasaka, Kenji Ikemura, Tomoyuki Enokiya, Yuichi Muraki, Mayumi Ikemura, Koji Terada, Takuya Iwamoto and Masahiro Okuda
    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:26
  43. Joint symptoms are a common side effect of aromatase inhibitors. However, it is not known if the risk of these symptoms varies between the members of this drug class. The aim of this study was to compare the f...

    Authors: Yoshihito Morimoto, Shuhei Sarumaru, Yuko Oshima, Chiho Tsuruta and Kazuhiro Watanabe
    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:25
  44. Varicose veins commonly occur in the lower extremities and can cause pain and discomfort in the affected area. Many patients with varicose veins suffer from itching, but its cause has not been sufficiently exp...

    Authors: Yasushi Takai, Keiichi Hiramoto, Yoshiyuki Nishimura, Ryota Uchida, Keigo Nishida and Kazuya Ooi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:24
  45. The advent of well-tolerated and effective anti-retroviral drugs against human immunodeficiency virus-1 (HIV-1) infection has been a major step forward that has achieved long-term survival in recent years. The...

    Authors: Takefumi Suzuki, Nobuko Hara, Morichika Osa, Kazuhisa Misawa, Kazuo Imai, Yuji Fujikura, Takuya Maeda, Wataru Sonehara and Akihiko Kawana
    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:23
  46. As of 2014, community pharmacies in Japan are approved by the Ministry of Health, Labour and Welfare to measure lipid panel, HbA1c, glucose, ALT, AST and γ-GTP, but not to screen for influenza virus. We provid...

    Authors: Akio Kawachi, Yusuke Sakamoto, Shunya Mouri, Mitsuaki Fukumori, Riku Kawano, Takaya Murakami, Junichiro Sonoda, Keiko Narumi, Yoshihiro Shimodozono, Kenji Etoh, Susumu Chiyotanda, Takashi Furuie, Keizo Sato, Masao Fukumori and Toshiro Motoya
    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:22
  47. In an evaluation of chemotherapy-induced peripheral neuropathy (CIPN), objectivity may be poor because the evaluation is determined by the patient’s subjective assessment. In such cases, management of neuropat...

    Authors: Junya Sato, Megumi Mori, Satoru Nihei, Satoshi Takeuchi, Masahiro Kashiwaba and Kenzo Kudo
    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:21
  48. In chemotherapy, the full round of treatment must be completed as scheduled to achieve the strongest therapeutic effect. However, peripheral neuropathy, a severe side effect of the chemotherapeutic agent pacli...

    Authors: Ken Konaka, Kota Moriyama, Takumi Sakurada, Naoto Okada, Masaki Imanishi, Yoshito Zamami, Kazuyoshi Kawazoe, Shuji Fushitani and Keisuke Ishizawa
    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:20
  49. Drug-induced gingival hyperplasia (DIGH) causes problems with chewing, aesthetics, and pronunciation, and leads to the deterioration of the patient’s quality of life (QOL). Thus, the aim of this study was to e...

    Authors: Haruna Hatahira, Junko Abe, Yuuki Hane, Toshinobu Matsui, Sayaka Sasaoka, Yumi Motooka, Shiori Hasegawa, Akiho Fukuda, Misa Naganuma, Tomofumi Ohmori, Yasutomi Kinosada and Mitsuhiro Nakamura
    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:19
  50. Human papillomavirus (HPV) vaccines have been shown to be effective for the eradication of HPV and prevention of cervical cancer. However, the number of women who receive HPV vaccinations has decreased over th...

    Authors: Yukari Ogawa, Hinako Takei, Ryuichi Ogawa and Kiyoshi Mihara
    Citation: Journal of Pharmaceutical Health Care and Sciences 2017 3:18

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