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  1. Brinzolamide (BRI) suspensions are used for the treatment of glaucoma; however, sufficient drug delivery to the target tissue after eye drop administration is hampered by poor solubility. To address this issue...

    Authors: Shuya Masuda, Shiho Yano, Tomohisa Tadokoro, Hiroko Otake and Noriaki Nagai
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:55
    Content type: Research article Published on:

  2. While nirmatrelvir/ritonavir (NMV-r) has been positioned as a first-line treatment for mild to moderate COVID-19, it has multiple and significant drug-drug interactions (DDIs). The use of NMV-r in Japan has be...

    Authors: Takeshi Tomida, Takeshi Kimura, Kazuhiro Yamamoto, Atsushi Uda, Yuki Matsumoto, Naoki Tamura, Masashi Iida, Akiko Tanifuji, Kumiko Matsumoto, Naomi Mizuta, Kei Ebisawa, Goh Ohji, Tomohiro Omura, Kentaro Iwata and Ikuko Yano
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:54
    Content type: Research article Published on:

  3. Fosphenytoin (FOS) is a prodrug of phenytoin (PHT) with a metabolism that exhibits Michaelis–Menten-type kinetics. Genetic polymorphisms of the metabolic enzymes of PHT make it challenging to predict its plasm...

    Authors: Ayumu Nagamine, Takuya Araki, Hideaki Yashima, Kiyohiro Oshima, Kyoko Obayashi and Koujirou Yamamoto
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:53
    Content type: Case report Published on:

  4. Interstitial lung disease (ILD) is one of the most common fatal immune-related adverse events (irAEs). ILD development adversely affects the continuation of anticancer drug therapy, including immune checkpoint...

    Authors: Mari Yokoi, Atsushi Yonezawa, Daiki Hira, Tomohiro Handa, Kiminobu Tanizawa, Shunsaku Nakagawa, Masahiro Tsuda, Yasuaki Ikemi, Ryo Itotani, Hironori Yoshida, Motoo Nomura, Junichi Matsubara, Kosaku Murakami, Hiroaki Ozasa, Manabu Muto and Tomohiro Terada
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:52
    Content type: Research article Published on:

  5. Pre-existing hypertension is reportedly a major risk factor for bevacizumab-induced proteinuria. However, few studies have focused on the effects of blood pressure (BP) control on proteinuria during bevacizuma...

    Authors: Satoru Nihei, Junichi Asaka, Mizunori Yaegashi, Koichi Asahi and Kenzo Kudo
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:51
    Content type: Research article Published on:

  6. Naldemedine is an orally available peripherally acting μ-opioid receptor antagonist approved to treat opioid-induced constipation (OIC). It is contraindicated for patients with known or suspected gastrointesti...

    Authors: Hayato Yokota, Yumiko Akamine, Mizuki Kobayashi, Takuro Kitabayashi, Misato Horie, Tentaro Endo, Takechiyo Yamada and Masafumi Kikuchi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:50
    Content type: Case report Published on:

  7. Fasudil and ozagrel are drugs with the same indications for the treatment of cerebral vasospasm in Japan. However, there have been no definitive conclusions on the clinical efficacy of fasudil hydrochloride an...

    Authors: Hiroshi Magara, Takuaki Tani, Shinobu Imai, Anna Kiyomi, Kiyohide Fushimi and Munetoshi Sugiura
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:49
    Content type: Research article Published on:

  8. Drug-drug interactions (DDIs) increase the incidence of adverse drug reactions (ADRs). In a previous report, we revealed that the incidence of potential DDIs due to the same CYP molecular species in one prescr...

    Authors: Rina Matsuoka, Shinsuke Akagi, Tomohiro Konishi, Masashi Kondo, Hideki Matsubara, Shohei Yamamoto, Keiji Izushi and Yuichi Tasaka
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:48
    Content type: Research article Published on:

  9. Polypharmacy is an escalating public health concern across various healthcare settings worldwide. We aimed to comprehensively investigate postoperative complications after laparoscopic surgery for colorectal c...

    Authors: Takashi Watanabe, Shota Kashiwagura, Ryusuke Ouchi, Kensuke Usui, Chikashi Shibata and Kouji Okada
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:47
    Content type: Research article Published on:

  10. We examined whether the pharmacodynamic drug–drug interaction between esaxerenone and trimethoprim enhances the hyperkalemic effect.

    Authors: Toshinori Hirai, Shun Ueda, Toru Ogura, Kan Katayama, Kaoru Dohi, Yuki Kondo, Yuka Sakazaki, Yoichi Ishitsuka and Takuya Iwamoto
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:46
    Content type: Research article Published on:

  11. Pneumonia is a common infection in patients of all ages. Determining its etiology and selecting antibiotic therapy are challenging for physicians in both private practice and hospitals. Moreover, the coronavir...

    Authors: Hideo Kato
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:45
    Content type: Review Published on:

  12. Dispensed drugs stored by patients are often in single-dose packages (SDPs) or are crushed and mixed after being removed from a press-through package (PTP) sheet. Information on their stability is extremely li...

    Authors: Yuriko Murai, Kasumi Kudo, Hiroyuki Suzuki, Taisuke Konno, Yasuyuki Agatsuma and Hitoshi Nakamura
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:44
    Content type: Research article Published on:

  13. Nonhealing diabetic wounds are a serious complication associated with extremely lethargic wound closure and a high risk of infection, leading to amputation or limb loss, as well as substantial health care cost...

    Authors: Moustafa H. Moustafa, Mohamed S. Turkey, Noha S. Mohamedin, Amira A. Darwish, Amira A. M. Elshal, Mona A. H. Yehia, Mohamed M. El Safwany and Ehab I. Mohamed
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:43
    Content type: Research article Published on:

  14. Authors: Tamrat Assefa Tadesse, Amha Gebremedhin, Dejuma Yadeta, Legese Chelkeba and Teferi Gedif Fenta
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:42
    Content type: Publisher Correction Published on:

    The original article was published in Journal of Pharmaceutical Health Care and Sciences 2024 10:32

  15. Fentanyl is widely used as an analgesic and sedative for patients with severe burn injuries in intensive care units. However, pharmacokinetic (PK) data for fentanyl, particularly for continuous intravenous inf...

    Authors: Takafumi Nakano, Yasuhisa Oida, Shinichi Morimoto, Kentaro Muranishi, Soichiro Ushio, Takuya Yamashina, Masanobu Uchiyama, Kenichi Mishima, Kiyoyuki Kitaichi, Yoshihiko Nakamura and Koichi Matsuo
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:41
    Content type: Case report Published on:

  16. Gentamicin is a commonly used antibiotic with synergistic effects that is administered once or multiple times daily. However, the influence of the daily administration frequency on renal function has not yet b...

    Authors: Kyohei Sugiyama, Keita Hirai, Yukako Suyama and Masato Tsutsumi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:40
    Content type: Research article Published on:

  17. Treating refractory status epilepticus (RSE) remains a challenge. Thiamylal can be used as a second- or third-line treatment; however, its potential to induce cytochrome P450 (CYP) activity may reduce the conc...

    Authors: Kazutaka Oda, Tomomi Katanoda, Hitomi Arakaki, Taiki Katsume, Kaho Matsuyama, Hirofumi Jono and Hideyuki Saito
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:39
    Content type: Case report Published on:

  18. Perioperative management of patients on dialysis is critical for controlling bleeding and thrombotic risk, in addition to infection control. Postoperative anticoagulation is often difficult to control, and dif...

    Authors: Masanori Suzuki, Yuki Hasegawa, Hiroaki Tanabe, Masayoshi Koinuma and Ryohkan Funakoshi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:38
    Content type: Research article Published on:

  19. Among the oral antivirals used for treating patients with mild-to-moderate novel coronavirus disease 2019 (COVID-19), nirmatrelvir/ritonavir (NMV/RTV) and ensitrelvir (ESV) are inhibitors of cytochrome P450 (C...

    Authors: Hanako Naganawa, Yoshiki Katada, Shunsaku Nakagawa, Keisuke Umemura, Hiroki Ishimura, Moto Kajiwara, Hiroki Endo, Mitsuhiro Sugimoto, Yurie Katsube, Kinuka Kotani, Saki Ohta, Daiki Hira, Masahiro Tsuda, Yuki Kita, Takashi Kobayashi and Tomohiro Terada
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:37
    Content type: Case report Published on:

  20. Anamorelin is expected to improve cancer cachexia by increasing lean body mass (LBM) due to increased appetite and protein synthesis. However, the effect of anamorelin on cancer cachexia in real-world practice...

    Authors: Hironori Fujii, Akitaka Makiyama, Kayoko Nishimura, Hirotoshi Iihara, Chiemi Hirose, Koichi Ohata, Yunami Yamada, Daichi Watanabe, Itaru Yasufuku, Naoki Okumura, Yoshihiro Tanaka, Takao Takahashi, Ryo Kobayashi, Nobuhisa Matsuhashi and Akio Suzuki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:36
    Content type: Research article Published on:

  21. We developed a reliable high-performance liquid chromatographic analysis method using a relative molar sensitivity (RMS) technique that does not require an authentic, identical reference analyte material to qu...

    Authors: Takashi Ohtsuki, Yi Huang, Ayane Kamiya, Yuki Nakayama, Miyuki Matsushita, Satoru Morikawa and Hiroshi Matsufuji
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:35
    Content type: Research article Published on:

  22. Guideline-directed medical therapy (GDMT) is important in heart failure management; however, polypharmacy itself may impact heart failure. Although measures against polypharmacy are needed, current discussion ...

    Authors: Daisuke Hayashi, Yoshiaki Kubota, Takuya Nishino, Yukihiro Watanabe, Yoshiki Iwade, Junya Matsuda, Katsuhito Kato, Shuhei Tara, Yuya Ise, Yu-ki Iwasaki and Kuniya Asai
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:34
    Content type: Research article Published on:

  23. Anamorelin, a drug to treat cancer cachexia, binds to ghrelin receptors and improves body weight and appetite. In clinical trials in Japan, patients experienced a 10.7% frequency of stimulant conduction system...

    Authors: Hayato Yokota, Ruriko Asahi, Yumiko Akamine, Mizuki Kobayashi, Hiyu Wakabayashi, Sho Sakamoto, Yuji Okuda, Kazuhiro Sato, Katsutoshi Nakayama and Masafumi Kikuchi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:33
    Content type: Case report Published on:

  24. We aimed to compare anticoagulation control and outcomes between usual medical care (UMC) and pharmacist-led anticoagulation services (PLAS) in patients receiving warfarin at the Tikur Anbessa Specialized Hosp...

    Authors: Tamrat Assefa Tadesse, Amha Gebremedhin, Dejuma Yadeta, Legese Chelkeba and Teferi Gedif Fenta
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:32
    Content type: Research article Published on:

    The Publisher Correction to this article has been published in Journal of Pharmaceutical Health Care and Sciences 2024 10:42

  25. The improvement in flowability and adhesion of starch powder (SP) is essential for using starch as an excipient for lactose intolerant patients. In this study, we attempted to evaluate the usefulness of hydrox...

    Authors: Tomohiro Yoshikawa, Hiroyo Okamoto, Kenta Takeuchi, Atsushi Hirata, Hiroko Otake and Noriaki Nagai
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:31
    Content type: Short report Published on:

  26. Based on several case reports and observational studies, there is a growing concern regarding the potential association between roxadustat, a hypoxia-inducible factor prolyl-hydroxylase inhibitor, and suppress...

    Authors: Yuki Nakano, Satoru Mitsuboshi, Kazuhiro Tada and Kosuke Masutani
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:30
    Content type: Research article Published on:

  27. Patient satisfaction is a crucial humanistic outcome metric in pharmacy services. There was a lack of evidence on patients’ satisfaction with pharmacy services in Gamo zone among users and nonusers of the CBHI...

    Authors: Fitsum Teferi Gulta, Tidenek Mulugeta, Biruk Wogayehu and Mende Mensa
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:29
    Content type: Research article Published on:

  28. Ganciclovir and its prodrug, valganciclovir, are first-line agents for cytomegalovirus infection prophylaxis after lung transplantation. Although valganciclovir prophylaxis is known to result in severe leukope...

    Authors: Yoshiki Katada, Keisuke Umemura, Shunsaku Nakagawa, Yurie Katsube, Masahiro Tsuda, Satona Tanaka, Hiroshi Date, Miki Nagao and Tomohiro Terada
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:28
    Content type: Case report Published on:

  29. People living with human immunodeficiency virus (PLWH) require high rates of medication adherence to antiretroviral therapy (ART) for a successful treatment outcome. Understanding the factors associated with i...

    Authors: Yusuke Kunimoto, Shinichi Hikasa, Masashi Ishihara, Mariko Tsukiji, Kazuko Nobori, Takeshi Kimura, Kenta Onishi, Yuuki Yamamoto, Kyohei Haruta, Yohei Kasiwabara, Kenji Fujii and Masahide Fukudo
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:27
    Content type: Research article Published on:

  30. Ipilimumab (Ipi) plus nivolumab (Nivo) is the recommended first-line treatment for renal cell carcinoma (RCC). This report describes a case where pancreatic metastases disappeared after only two courses of Ipi...

    Authors: Ryo Takada, Miki Fujiwara, Masatoshi Maki, Naoyuki Nomura, Shintaro Kono, Akira Fujita, Hiroshi Masumoto, Yoko Takahashi, Yasuhisa Hasegawa and Koji Tamura
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:26
    Content type: Case report Published on:

  31. COMISA is a common disorder that results in nighttime awakenings ,daytime sleepiness and PAP intolerance. Cognitive behavioral therapy for insomnia is used to improve PAP adherence and no medication has been e...

    Authors: Tahereh Madani Motlaq, Besharat Rahimi and Shahideh Amini
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:25
    Content type: Research article Published on:

  32. Pimobendan reportedly improves the subjective symptoms of heart failure. However, evidence of improved prognosis is lacking. This study aimed to determine whether reinforcing guideline-directed medical therapy...

    Authors: Yoshiki Iwade, Yoshiaki Kubota, Daisuke Hayashi, Takuya Nishino, Yukihiro Watanabe, Katsuhito Kato, Shuhei Tara, Yuya Ise and Kuniya Asai
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:24
    Content type: Short report Published on:

  33. Coronary heart disease, also known as ischemic heart disease, is induced by atherosclerosis, which is initiated by subendothelial retention of lipoproteins. Plasma lipoproteins, including high density lipoprot...

    Authors: Shin-ya Morita
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:23
    Content type: Review Published on:

  35. Pharmacists should be aware of their thought processes in dispensing work, including differences in the dispensing complexities owing to different drug positions in the left, center, and right areas. Dispensin...

    Authors: Toshikazu Tsuji, Kenichiro Nagata, Masayuki Tanaka, Shigeru Hasebe, Takashi Yukita, Mayako Uchida, Kimitaka Suetsugu, Takeshi Hirota and Ichiro Ieiri
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:21
    Content type: Research article Published on:

  36. The relationship between plasma tenofovir (TFV) concentration at the beginning of tenofovir disoproxil fumarate (TDF) administration and the development of renal dysfunction during long-term administration of ...

    Authors: Hiroki Yagura, Dai Watanabe, Takao Nakauchi, Hiroyuki Kushida, Kazuyuki Hirota, Yasuharu Nishida, Munehiro Yoshino, Tomoko Uehira and Takuma Shirasaka
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:20
    Content type: Research article Published on:

  37. Medication errors related to the pre-admission medication history obtained on admission are a major cause of medication error during hospitalization. Medication reconciliation (MR) improves patient safety thro...

    Authors: Yunami Yamada, Ryo Kobayashi, Taishi Yamamoto, Hironori Fujii, Hirotoshi Iihara, Kato-Hayashi Hiroko, Shohei Nishida, Ryo Hoshino, Takashi Niwa, Keisuke Kumada, Masahito Shimizu and Akio Suzuki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:19
    Content type: Research article Published on:

  38. Patients with a history of hepatitis B virus (HBV) infection who are receiving immunosuppressive therapy are at risk of HBV reactivation and disease. Therefore, HBV screening is required prior to administering...

    Authors: Yuki Yanagisawa, Shungo Imai, Hayato Kizaki and Satoko Hori
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:18
    Content type: Research article Published on:

  39. Methotrexate (MTX) is an antineoplastic/immunosuppressive drug, whose clinical use is impeded owing to its serious adverse effects; one of which is acute kidney injury (AKI). Most of MTX complications emerged ...

    Authors: Mustafa Ahmed Abdel-Reheim, Merhan E. Ali, Ahmed Gaafar A. Gaafar and Ahmed Amine Ashour
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:17
    Content type: Research article Published on:

  40. Human resource management may become complex for community pharmacists owing to recent changes in work volume and content. Few studies have examined job satisfaction, well-being, and quality of work life (QWL)...

    Authors: Yuta Kato, Takashi Sekiya, Ryo Ishii, Yoji Hirako, Hiroki Satoh and Hiromichi Kimura
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:16
    Content type: Research article Published on:

  41. Cancer has been identified as a risk factor for severe illness and mortality in coronavirus disease (COVID-19), underscoring the importance of recommending COVID-19 vaccinations to patients with cancer. Howeve...

    Authors: Satoshi Iwakawa, Takuya Azechi, Orie Saigo, Ryunosuke Imai, Ayumi Nakai, Shoji Koshiba, Uki Saito, Kota Asakura, Kuniyoshi Sato and Toshimi Kimura
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:15
    Content type: Research article Published on:

  42. Although pharmacists often identify numerous clinical questions, they face several barriers, including the lack of mentors for research activities in clinical settings. Therefore, a workshop for the appropriat...

    Authors: Yuki Asai, Yasushi Takai, Toshiki Murasaka, Tomohiro Miyake, Tomohisa Nakamura, Yoshihiko Morikawa, Yuji Nakagawa, Tatsuya Kanayama, Yasuharu Abe, Naoki Masuda, Yasushi Takamura, Yoshihiro Miki and Takuya Iwamoto
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:14
    Content type: Short report Published on:

  43. Continued use of tenofovir disoproxil fumarate (TDF), an antiretroviral drug, causes renal function decline and tubular damage in individuals with HIV. While tenofovir alafenamide fumarate (TAF) may have less ...

    Authors: Kensuke Abe, Junji Imamura, Akiko Sasaki, Tomoko Suzuki, Satomi Kamio, Taku Obara and Toshihiro Ito
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:13
    Content type: Research article Published on:

  44. Infusion-related reactions (IRRs) are major side effects of rituximab administration. Male sex, high body weight, body surface area (BSA), and body mass index are predictive markers of rituximab-induced IRRs. ...

    Authors: Hironobu Nishiura, Masaya Takahashi, Katsuhito Mori, Takashi Sugimoto, Masanori Emoto and Yasutaka Nakamura
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:12
    Content type: Short report Published on:

  45. We evaluated the predictive factors for surgical site infections (SSIs) in elective colorectal cancer surgery and the role of antimicrobial stewardship (AS) pharmacists in modifying the clinical pathway.

    Authors: Yasuhiro Sasaki, Akira Kurishima, Chieko Miyamoto, Kenichiro Hataji, Toru Tezuka and Hideo Katsuragawa
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:11
    Content type: Short report Published on:

  46. Pembrolizumab can cause immune-related adverse events such as adrenal insufficiency (AI). However, there is no consensus regarding appropriate monitoring of adrenal function during subsequent chemotherapy in p...

    Authors: Tatsuhiro Fujimiya, Kanako Azuma, Yuki Togashi, Koji Kuwata, Sakae Unezaki and Hironori Takeuchi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:10
    Content type: Case report Published on:

  47. Hospital pharmacists are important in antibiotic stewardship programs (ASP), a global strategy to combat antibiotic resistance (ABR). South African public hospitals have limited ASP implementation. This study ...

    Authors: Tiyani Comfort Mthombeni, Johanita Riétte Burger, Martha Susanna Lubbe and Marlene Julyan
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:9
    Content type: Research article Published on:

  48. Corticosteroid-containing medications are widely accessible in various forms, including topical, injectable, and inhaled formulations. Due to uncertain safety profiles, healthcare providers, including pharmaci...

    Authors: Muna Barakat, Samar Thiab, Rana Abu Farha, Anas O. Alshweiki, Roa’a Thaher, Asem Alsughaier and Diana Malaeb
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:8
    Content type: Research article Published on:

  49. Multidrug-resistant bacterial strains cause several serious infections that can be fatal, such as Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumonia, Acinetobacter baumannii, Pseudomonas aeruginosa

    Authors: Showkat Ahmad Bhat, Mohammed Iqbal Zargar, Shahid Ud Din Wani, Ishfaq Mohiuddin, Mubashir Hussain Masoodi, Faiyaz Shakeel, Mohammad Ali and Seema Mehdi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:7
    Content type: Research article Published on:

  50. Hospitals in Japan established the healthcare delivery system from FY 2018 to 2021 by acquiring an additional reimbursement for infection prevention (ARIP) of category 1 or 2. However, research on outcomes of ...

    Authors: Yuichi Tasaka, Takeshi Uchikura, Shiro Hatakeyama, Daisuke Kikuchi, Masami Tsuchiya, Ryohkan Funakoshi and Taku Obara
    Citation: Journal of Pharmaceutical Health Care and Sciences 2024 10:6
    Content type: Research article Published on:
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Journal of Pharmaceutical Health Care and Sciences

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