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  1. Loxoprofen is a propionic acid derivative and is the most widely prescribed non-steroidal anti-inflammatory drug in Japan. Loxoprofen is generally considered to be relatively nontoxic.

    Authors: Koichiro Adachi, Yuki Sugitani, Ryo Unita, Kosuke Yoshida, Satoru Beppu, Mariko Terashima, Masaya Fujii, Makiko Shimizu and Hiroshi Yamazaki

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:33

    Content type: Case report

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  2. Clonidine hydrochloride is used to treat sedative agent withdrawals, malignant hypertension, and anesthesia complications. Clonidine is also prescribed off-label to pediatric patients at a dose of 1 μg/kg. The...

    Authors: Jumpei Saito, Takehisa Hanawa, Takahiro Matsumoto, Nozomi Yoshikawa, Tsutomu Harada, Kana Iwahashi, Hidefumi Nakamura and Akimasa Yamatani

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:31

    Content type: Research article

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  3. Anticholinergic burden potentially increases the risk of fracture. Although there are various anticholinergic burden scales, little is known about the inter-scale compatibility regarding the relationship of an...

    Authors: Yukari Ogawa, Toshinori Hirai and Kiyoshi Mihara

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:30

    Content type: Research article

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  4. The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is the most frequent cause of hyponatremia in patients with cerebrovascular disease, and is often treated with oral salt tablets. However...

    Authors: Miyuki Takemura, Yuki Tanaka, Katsuhisa Inoue, Ikumi Tamai and Yoshiyuki Shirasaka

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:29

    Content type: Research article

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  5. Although the over-the-counter H1 receptor antagonist diphenhydramine is not a common drug of abuse, it was recently recognized as one of the substances causing acute poisoning in patients attempting suicide that ...

    Authors: Koichiro Adachi, Satoru Beppu, Mariko Terashima, Wataru Kobari, Makiko Shimizu and Hiroshi Yamazaki

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:32

    Content type: Case report

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  6. Currently, in Japan, shifting tasks from physician to hospital pharmacist is being developed to reduce physician workload and improve the quality of pharmacotherapy. This study aimed to investigate the effects...

    Authors: Eiji Shiwaku, Satoshi Dote, Shinobu Kaneko, Chisato Hei, Masaki Aikawa, Yuki Sakai, Takahiro Kawai, Shigeaki Iwatsubo, Michinobu Hashimoto, Teppei Tsuneishi, Tomoko Nishimura, Toshiyuki Iwata, Daiki Hira, Tomohiro Terada, Takashi Nishimura and Yuka Kobayashi

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:28

    Content type: Research article

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  7. Cancer chemotherapy usually improves clinical outcomes in patients with advanced pancreatic cancer (APC), but can also cause moderate-to-severe adverse events (AEs). We investigated the relationship between mo...

    Authors: Hironori Fujii, Maaya Koda, Shiori Sadaka, Koichi Ohata, Hiroko Kato-Hayashi, Hirotoshi Iihara, Ryo Kobayashi, Takuma Ishihara, Shinya Uemura, Takuji Iwashita, Hideki Hayashi, Tadashi Sugiyama, Masahito Shimizu and Akio Suzuki

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:27

    Content type: Research article

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  8. Antimicrobial stewardship (AS) is defined as coordinated interventions to improve and measure the appropriate use of antimicrobial agents. However, available resources for AS differ depending on the size of th...

    Authors: Satoshi Nakamura, Takashi Arima, Ryoichi Tashiro, Satomi Yasumizu, Hayato Aikou, Emi Watanabe, Takashi Nakashima, Yuho Nagatomo, Ikuyo Kakimoto and Toshiro Motoya

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:25

    Content type: Research article

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  9. A chemopreventive effect of low-dose aspirin against colorectal tumors was previously found in participants of two Japanese multicenter, double-blind, randomized, placebo-controlled clinical trials investigati...

    Authors: Hiroshi Yamazaki, Makiko Shimizu, Takahiro Otani, Ami Mizugaki, Kanae Mure, Sadao Suzuki and Hideki Ishikawa

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:26

    Content type: Short report

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  10. Irinotecan (CPT-11) is clinically known to cause severe diarrhea and gastrointestinal damage. Recently, we have reported that CPT-11-induced gastrointestinal damage is associated with the upregulation of intes...

    Authors: Toshiaki Tsuchitani, Takeshi Akiyoshi, Ayuko Imaoka and Hisakazu Ohtani

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:24

    Content type: Research article

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  11. A multicenter investigation of neonate exposure to potentially harmful excipients (PHEs) in neonatal intensive care units (NICUs) in Japan has not been conducted.

    Authors: Jumpei Saito, Naomi Nadatani, Makoto Setoguchi, Masahiko Nakao, Hitomi Kimura, Mayuri Sameshima, Keiko Kobayashi, Hiroaki Matsumoto, Naoki Yoshikawa, Toshihiro Yokoyama, Hitomi Takahashi, Mei Suenaga, Ran Watanabe, Kinuko Imai, Mami Obara, Mari Hashimoto…

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:23

    Content type: Research article

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  12. Renal function and use of concomitant medications should be carefully monitored in patients subjected to treatment with direct oral anticoagulants (DOACs); the dose should be individually designed for each pat...

    Authors: Naoto Ishikawa, Hanae Oshikiri, Shinya Takasaki, Masafumi Kikuchi, Taku Obara, Kazutoshi Akasaka, Masaki Matsuura, Hiroaki Yamaguchi and Nariyasu Mano

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:22

    Content type: Research article

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  13. Recently, aprepitant has been recommended in carboplatin-based regimens, but there are limited reports on the efficacy of administering aprepitant, palonosetron, and dexamethasone (DEX) in carboplatin-containi...

    Authors: Yuko Watanabe, Yoshitaka Saito, Takashi Mitamura, Yoh Takekuma and Mitsuru Sugawara

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:21

    Content type: Research article

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  14. Neonatal populations are quite susceptible to drug-related problems (DRPs) because of clinical heterogeneity and clinical practice trends. However, studies reporting DRPs in the neonatal population are quite l...

    Authors: Mengist Awoke, Tsegaye Melaku and Mohammed Beshir

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:20

    Content type: Research article

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  15. In clinical practice, a mixed suspension of clopidogrel bisulfate and magnesium oxide (MgO) tablets is administered frequently via a feeding tube. However, there is no report on the changes occurring when susp...

    Authors: Manahito Aoki, Midori Naya, Shiho Arima, Kaori Shinohara, Masahiro Kato, Kiyoshi Shibuya, Masaki Ohtawa, Tohru Nagamitsu and Katsuya Otori

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:18

    Content type: Research article

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  16. Primary angle closure disease (PACD) is a type of glaucoma in which the intraocular pressure (IOP) is increased because of the blockage of the anterior chamber angle. Medications contraindicated for patients w...

    Authors: Fumiaki Tanaka, Naoki Shibatani, Kazumi Fujita, Hiroaki Ikesue, Satoru Yoshimizu, Nobuyuki Muroi, Yasuo Kurimoto and Tohru Hashida

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:17

    Content type: Research article

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  17. Frailty is an urgent concern among an aging population worldwide. However, the relationship between frailty and number and types of medications has not been studied in detail among early-stage older patients, ...

    Authors: Yuya Uragami, Kazuhiro Takikawa, Hajime Kareki, Koji Kimura, Kazuyuki Yamamoto and Naomi Iihara

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:15

    Content type: Research article

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  18. Several studies have reported the implementation of nutrition therapy and rehabilitation for acute and critical illnesses. However, rehabilitation nutrition for elderly sarcopenia patients with extremely sever...

    Authors: Michiyo Tatsumi, Satomi Kumagai, Takahiro Abe, Soichi Murakami, Hiroshi Takeda, Toshiaki Shichinohe, Yuko Watanabe, Shinsuke Katayama, Shiaki Hirai, Aiko Honda, Yoh Takekuma and Mitsuru Sugawara

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:16

    Content type: Case report

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  19. Drug shortage is a significant public health problem, especially for drugs related to life threatening conditions. Almost all countries affected by variety of supply problems and spent a considerable amount of...

    Authors: Asiye Moosivand, Maryam Rangchian, Leila Zarei, Farzad Peiravian, Gholamhossein Mehralian and Hesameddin Sharifnia

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:14

    Content type: Research article

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  20. The recognition, prevention and treatment of venous thromboembolism (VTE) remains a major challenge in the face of the recent COVID-19 pandemic which has been associated with significant cardiovascular, renal,...

    Authors: Laura Gillespie, Rashid Z. Khan, John E. Stillson, Connor M. Bunch, Faisal Salim Shariff, Jacob Speybroeck, Anne Grisoli, Meredith Wierman Schmidt, Htay Phyu, Jason Jablonski, Byars Wells, Daniel H. Fulkerson, Lyndsay Oancea, Abraham Leiser and Mark Walsh

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:19

    Content type: Research article

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  21. Since antipsychotics induce hyperprolactinemia via the dopamine D2 receptor, long-term administration may be a risk factor for developing breast tumors, including breast cancer. On the other hand, some antipsycho...

    Authors: Tae Maeshima, Ryosuke Iijima, Machiko Watanabe, Satoru Yui and Fumio Itagaki

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:13

    Content type: Research article

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  22. Migraine is a painful and disabling nervous disorder which negatively affects the quality of life. Migraineurs may suffer from a generalized vasomotor dysfunction. Statins improve vasomotor and vascular functi...

    Authors: Reza Ganji, Nastaran Majdinasab, Saeed Hesam, Nazanin Rostami, Mehdi Sayyah and Adeleh Sahebnasagh

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:12

    Content type: Research article

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  23. Various factors are related to self-management of medication. However, few reports comprehensively examine the factors related to patients, medication levels, and other factors related to the recuperative envi...

    Authors: Eiji Kose, Hidetatsu Endo, Hiroko Hori, Shingo Hosono, Chiaki Kawamura, Yuta Kodama, Takashi Yamazaki and Nobuhiro Yasuno

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:11

    Content type: Research article

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  24. Patients with chronic heart failure (CHF) are often treated using many diuretics for symptom relief; however, diuretic use may have to continue despite hypotension development in these patients. Here, we prese...

    Authors: Yuki Asai, Tomoaki Sato, Daisuke Kito, Takanori Yamamoto, Iwao Hioki, Yasuhisa Urata and Yasuharu Abe

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:10

    Content type: Case report

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  25. Although the exact mechanism involved in migraine pathogenesis remained uncertain, and different researches have been developed to address the role of neuroinflammation and immune dysfunction. Therefore, consi...

    Authors: Zeinab Ghorbani, Pegah Rafiee, Samaneh Haghighi, Soodeh Razeghi Jahromi, Mahmoud Djalali, Hedieh Moradi-Tabriz, Maryam Mahmoudi and Mansoureh Togha

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:9

    Content type: Research article

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  26. Pharmaceutical care of capecitabine-related hand–foot syndrome (HFS) is extremely important to avoid the progression of the syndrome. Protocol-based pharmacotherapy management (PBPM) of HFS by community pharma...

    Authors: Nobuhiko Nakamura, Hiroki Shiraiwa, Yasuhiro Haruna, Tomoki Ichijima, Tomoko Takeda, Koji Hasegawa, Masaaki Kusumoto and Yoshitaka Yano

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:8

    Content type: Research article

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  27. Combinations of antidepressant duloxetine (at doses of 40–60 mg/day) and other antipsychotics are frequently used in clinical treatment; however, several fatal and nonfatal cases of duloxetine overdose have be...

    Authors: Koichiro Adachi, Satoru Beppu, Kei Nishiyama, Makiko Shimizu and Hiroshi Yamazaki

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:6

    Content type: Case report

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  28. Phenobarbital (PB) is commonly used as elixir and powder formulations in pediatric care. Its dose adjustment is performed based on individual drug concentration monitoring. Few studies have comprehensively ana...

    Authors: Chihiro Shiraishi, Hiroko Matsuda, Toru Ogura and Takuya Iwamoto

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:7

    Content type: Research article

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  29. The standard anticoagulation therapy for patients implanted with left ventricular assist devices (LVADs) includes warfarin therapy. We developed a cloud-based home medical management information-sharing system...

    Authors: Yoshiki Katada, Atsushi Yonezawa, Momoe Utsumi, Noriaki Kitada, Yu-ki Sato, Katsuyuki Matsumura, Asami Sukeishi, Shunsaku Nakagawa, Satoshi Imai, Takayuki Nakagawa, Kenji Minakata, Hideo Kanemitsu, Kenji Minatoya, Shinichi Nomoto and Kazuo Matsubara

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:5

    Content type: Case report

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  30. The most common adverse event (AE) associated with opioid analgesics is opioid-induced constipation (OIC). Naldemedine (NAL) is widely used for the treatment of OIC. However, diarrhea has been reported as the ...

    Authors: Akiharu Okamoto, Kenji Ikemura, Eri Mizutani, Takuya Iwamoto and Masahiro Okuda

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:3

    Content type: Research article

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  31. Fibrocystic changes are a common benign condition in women aged 20–50. The medical intervention aims to stop fibrocystic disease progress and relieve the breast’s pain and tenderness. In the long-term, reversi...

    Authors: Gholamali Godazandeh, Shahram Ala, Tahereh Madani Motlaq, Adeleh Sahebnasagh and Aliyeh Bazi

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:4

    Content type: Research article

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  32. Elastomeric pumps (EPs) are devices that allow quantitative and continuous drug administration without the need for electronic control, and they are used by being filled with anticancer agents. Although the pa...

    Authors: Tomoya Abe, Kazumasa Matsuzaka, Toshiaki Nakayama, Masanobu Otsuka, Atsunobu Sagara, Fumiaki Sato and Tetsuro Yumoto

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:1

    Content type: Research article

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  33. The effects of general anesthesia with deep sedation and conscious sedation have been compared for sedation management in the perioperative period for radiofrequency catheter ablation of the heart to treat atr...

    Authors: Teruhisa Kinoshita, Mitsunori Harada, Norio Takimoto, Daichi Shibata, Takashi Sakakibara and Mamoru Adachi

    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:2

    Content type: Research article

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  34. Generic drugs are heavily promoted in Japan. The aim of this retrospective single-center study was to clarify whether the frequency and reason that patients request a switch from a generic drug to the original...

    Authors: Yuhei Hamada, Masashi Uchida, Sayaka Arai, Kaori Yamazaki, Mariko Takeda, Kenichi Arai, Takako Nakamura, Takaaki Suzuki and Itsuko Ishii

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:27

    Content type: Research article

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  35. Although recombinant human soluble thrombomodulin (rTM) has been widely used to treat disseminated intravascular coagulation (DIC) in Japan, there is no consensus regarding rTM efficacy. Therefore, if the fact...

    Authors: Yuki Asai, Takanori Yamamoto, Daisuke Kito, Kazuya Ichikawa and Yasuharu Abe

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:26

    Content type: Short report

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  36. Xanthan gum-based food thickeners (XG-FTs) are often ingested by patients with dysphagia to prevent aspiration during drug treatment. Reportedly, XG-FTs affect tablet disintegration, drug dissolution rates, an...

    Authors: Nobuyuki Takahashi, Yoshiaki Fujita, Nanako Takahashi, Akihiro Nakamura and Tsutomu Harada

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:25

    Content type: Research article

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  37. While the world’s population is growing older, healthy life expectancy is not increasing. The Japanese Orthopedic Association proposed the concept of ‘locomotive syndrome,’ manifested as a decline in mobility ...

    Authors: Chigusa Kikuchi, Kyoko Yamaguchi, Masayo Kojima, Haruyuki Asai, Rika Nakao, Yoshifusa Otake, Junya Nagata, Shinpei Matsunami, Asako Horiba and Tadashi Suzuki

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:24

    Content type: Research article

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  38. Permeability of antineoplastic agents through medical gloves is an important factor that must be considered for the appropriate selection of gloves. However, predicting the permeability of antineoplastic agent...

    Authors: Toyohito Oriyama, Takehito Yamamoto, Katsuhiko Nara, Yohei Kawano, Katsuyoshi Nakajima, Hiroshi Suzuki and Takao Aoyama

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:23

    Content type: Research article

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  39. We collaborated with the regional pharmaceutical associations near Nagoya Memorial Hospital and created a communication sheet for pharmaceutical cooperation between the hospital and health insurance pharmacies.

    Authors: Megumi Kabeya, Satoshi Hibi, Shu Yuasa, Satoshi Kayukawa and Kenji Ina

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:22

    Content type: Research article

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  40. Baloxavir marboxil (baloxavir) is a new anti-influenza virus agent that is comparable to oseltamivir phosphate (oseltamivir). Since the efficacy of baloxavir in preventing household transmission of influenza i...

    Authors: Takumi Umemura, Yoshikazu Mutoh, Takato Kawamura, Masayuki Saito, Takahito Mizuno, Aiko Ota, Koji Kozaki, Tetsuya Yamada, Yoshiaki Ikeda and Toshihiko Ichihara

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:21

    Content type: Research article

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  41. The anticoagulant edoxaban is used clinically at doses of 30–60 mg/day; however, we experienced a patient who had taken an overdose of edoxaban of 750 mg. We investigated the pharmacokinetics of edoxaban in th...

    Authors: Koichiro Adachi, Jumpei Tuchiya, Satoru Beppu, Kei Nishiyama, Makiko Shimizu and Hiroshi Yamazaki

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:20

    Content type: Case report

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  42. Bevacizumab (BEV) leads to proteinuria and renal damage. It is not clear whether the administration of immunosuppressive drugs after renal transplantation affects the safety of BEV administration. We report a ...

    Authors: Ren Onodera, Satoru Nihei, Toshimoto Kimura, Takashi Tomita and Kenzo Kudo

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:19

    Content type: Case report

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  43. Ward pharmacists are required for the active implementation of therapeutic drug monitoring (TDM). This epidemiological study verified whether Japanese ward pharmacists contribute to improving the TDM implement...

    Authors: Shungo Imai, Kenji Momo, Hitoshi Kashiwagi, Takayuki Miyai, Mitsuru Sugawara and Yoh Takekuma

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:18

    Content type: Research article

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  44. Many patients with critical lower limb ischemia are not eligible for revascularization procedures. Still, given the emerging role of both platelet and coagulation activation in the formation of arterial thromb...

    Authors: Antonio Trani, Pietro Benedetto, Ferdinando Di Leo, Angela Baiano, Andrea Esposito, Danilo Menna, Arianna Allegretti, Pierluigi Antonino Cappiello and Domenico Dell’Edera

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:17

    Content type: Case report

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  45. Valganciclovir (VGC) is essential for preventing cytomegalovirus infections after transplants in adult and pediatric patients. In pediatric patients, VGC tablets have to be pulverized so that they can be deliv...

    Authors: Yasuyuki Masaoka, Yoichi Kawasaki, Ryo Kikuoka, Atsushi Ogawa, Satoru Esumi, Yudai Wada, Soichiro Ushio, Yoshihisa Kitamura and Toshiaki Sendo

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:16

    Content type: Research article

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  46. Instillation of sterile graded talc in the pleural space is performed to prevent reaccumulation of malignant pleural effusion after drainage. Talc is thought to encourage pleural adhesions as part of the repai...

    Authors: Soichiro Ishii, Hiroshi Sakurashita, Emiko Mashida, Yasuyuki Saeki and Hiroaki Matsuo

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:15

    Content type: Case report

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  47. The need for a large volume of serum sample significantly reduces the feasibility of neonatal pharmacokinetic studies in daily practice, which must often rely on scavenged or opportunistic sampling. This probl...

    Authors: Jumpei Saito, Ayano Tanzawa, Yuka Kojo, Hidehiko Maruyama, Tetsuya Isayama, Kensuke Shoji, Yushi Ito and Akimasa Yamatani

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:14

    Content type: Research article

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  48. Patients with diabetes are at higher risk of developing polypharmacy because of the high frequency of comorbidities. There have been several reports on the hypoglycemic risk of the combination of hypoglycemic ...

    Authors: Tomoyuki Saito, Hirotoshi Ohmura, Shuko Nojiri and Hiroyuki Daida

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:13

    Content type: Research article

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  49. Oral mucositis frequently occurs in cancer patients treated with chemotherapy and chemoradiotherapy (CRT). This study examined the safety and efficacy of ibuprofen gargle in healthy volunteers and patients wit...

    Authors: Takeshi Ioroi, Naomi Kiyota, Yoshinori Imamura, Masaaki Tanda, Shiori Aoki, Mamoru Okuno, Kazuhiro Yamamoto, Ryohei Sasaki, Ken-ichi Nibu, Hironobu Minami, Midori Hirai and Ikuko Yano

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:12

    Content type: Research article

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  50. Itraconazole (ITZ), a triazole antifungal agent, is metabolized to hydroxy-ITZ (OH-ITZ), keto-ITZ (KT-ITZ), and N-desalkyl ITZ (ND-ITZ) by cytochrome P450 3A4. The pharmacokinetics of ND-ITZ remain largely unknow...

    Authors: Yumi Imoto, Yasuaki Mino, Takafumi Naito, Takaaki Ono and Junichi Kawakami

    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:11

    Content type: Research article

    Published on:

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Journal of Pharmaceutical Health Care and Sciences

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